Cited by 173Protein Degradation and InhibitorsUbiquitin and proteasome pathwaysChemical Synthesis and Analysis

The DOI matches its Crossref record; 106 of the 111 references it cites were found in a registry or an index.

Haven't got a glue: Protein surface variation for the design of molecular glue degraders

Open access

Kozicka, Zuzanna, Thomä, Nicolas Holger·2021·Cell Chemical Biology

DOI 10.1016/j.chembiol.2021.04.009

Open this paper in CoChat — free account Open PDF

Abstract

Molecular glue degraders are small, drug-like compounds that induce interactions between an E3 ubiquitin ligase and a target, which result in ubiquitination and subsequent degradation of the recruited protein. In recent years, serendipitous discoveries revealed that some preclinical and clinical compounds already work as molecular glue degraders, with many more postulated to destabilize their targets through indirect or yet unresolved mechanisms. Here we review strategies by which E3 ubiquitin ligases can be reprogrammed by monovalent degraders, with a focus on molecular glues hijacking cullin-RING ubiquitin ligases. We argue that such drugs exploit the intrinsic property of proteins to form higher-order assemblies, a phenomenon previously seen with disease-causing sequence variations. Modifications of the protein surface by a bound small molecule can change the interactome of the target protein. By inducing interactions between a ligase and a substrate, molecular glue degraders offer an exciting path for the development of novel therapeutics.

Integrity signals

Registry

Crossref · 10.1016/j.chembiol.2021.04.009

Cites

106 of 106 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Inference of Macromolecular Assemblies from Crystalline State
Krissinel, E., & Henrick, K. (2007) · Journal of Molecular Biology · doi:10.1016/j.jmb.2007.05.022 · Cited by 10,007
Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes
Liu, J., Farmer, J. D., Lane, W. S., Friedman, J., Weissman, I., & Schreiber, S. L. (1991) · Cell · doi:10.1016/0092-8674(91)90124-h · Cited by 4,116
Protacs: Chimeric molecules that target proteins to the Skp1–Cullin–F box complex for ubiquitination and degradation
Sakamoto, K. M., Kim, K. B., Kumagai, A., Mercurio, F., Crews, C. M., & Deshaies, R. J. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.141230798 · Cited by 2,609
Cyclin is degraded by the ubiquitin pathway
Glotzer, M., Murray, A. W., & Kirschner, M. W. (1991) · Nature · doi:10.1038/349132a0 · Cited by 2,359
Identification of a Primary Target of Thalidomide Teratogenicity
Ito, T., Ando, H., Suzuki, T., Ogura, T., Hotta, K., Imamura, Y., Yamaguchi, Y., & Handa, H. (2010) · Science · doi:10.1126/science.1177319 · Cited by 2,136
The mechanism of action of cyclosporin A and FK506
Schreiber, S. L., & Crabtree, G. R. (1992) · Immunology Today · doi:10.1016/0167-5699(92)90111-j · Cited by 2,127
An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer
Soucy, T. A., Smith, P. G., Milhollen, M. A., Berger, A. J., Gavin, J. M., Adhikari, S., Brownell, J. E., Burke, K. E., Cardin, D. P., Critchley, S., et al. (2009) · Nature · doi:10.1038/nature07884 · Cited by 1,990
Lenalidomide Causes Selective Degradation of IKZF1 and IKZF3 in Multiple Myeloma Cells
Krönke, J., Udeshi, N. D., Narla, A., Grauman, P., Hurst, S. N., McConkey, M., Svinkina, T., Heckl, D., Comer, E., Li, X., et al. (2014) · Science · doi:10.1126/science.1244851 · Cited by 1,879
Einfluss der Configuration auf die Wirkung der Enzyme
Fischer, E. (1894) · Berichte der deutschen chemischen Gesellschaft · doi:10.1002/cber.18940270364 · Cited by 1,841
Insights into Protein–Ligand Interactions: Mechanisms, Models, and Methods
Du, X., Li, Y., Xia, Y.-L., Ai, S.-M., Liang, J., Sang, P., Ji, X., & Liu, S.-Q. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17020144 · Cited by 1,765

Show all 111 references

Research works printed but not linked: 1

Yamanaka, 2020, PLZF is a new substrate of CRBN with thalidomide and 5-hydroxythalidomide, BioRxiv

Sorted by citations

Items 101–173 of 173

CRISPR-based gene therapy for the induction of fetal hemoglobin in sickle cell disease
McManus, M. P., Frangoul, H., & Steinberg, M. H. (2024) · Expert Review of Hematology · doi:10.1080/17474086.2024.2429605 · Cited by 8
Enabling cancer target validation with genetically encoded systems for ligand-induced protein degradation
Zhang, Y., & Erb, M. A. (2021) · Current Research in Chemical Biology · doi:10.1016/j.crchbi.2021.100011 · Cited by 7
Molecular Glue Degraders: From Serendipity to Hunting and Design
Nieto‐Barrado, L., Domostegui, A., & Mayor‐Ruiz, C. (2022) · Wiley eBooks · doi:10.1002/9783527836208.ch6 · Cited by 7
Visible‐Light‐Controlled Lysine‐Selective Crosslinking Decodes Protein Complexes and Dynamic Interactomes in Live Cells
Xu, Y., Hu, H., Ran, Y., Zhao, W., Guo, A., Nie, H., Zhai, L., Yin, G., Cheng, J., Tao, S., et al. (2025) · Angewandte Chemie International Edition · doi:10.1002/anie.202507254 · Cited by 7
Molecular glues: A new path to the world of the unattainable
Khaledian, M., Sheikh, H., Babaei, F., Divsalar, A., Gharshasbi, M., Ottmann, C., Haertlé, T., Saboury, A. A., & Rasouli, M. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.148861 · Cited by 7
Dual E3 ligase recruitment by monovalent degraders for tunable SMARCA 2/4 degradation
Spiteri, V. A., Segal, D., Correa-Sáez, A., Iso, K., Casement, R., Ordoño, M. M. I., Nakasone, M. A., Sathe, G. J., Schätz, C., Peters, H. E., et al. (2026) · Nature Chemical Biology · doi:10.1038/s41589-026-02224-y · Cited by 16
Serendipitous discovery of Class I HDAC inhibitors from rational design of molecular glue degraders targeting HDAC
Chen, D., Lin, S., Zeng, Z., An, J., Yan, W., Gu, Z., Chen, L., & He, B. (2023) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2023.115926 · Cited by 6
Mechanism by which the molecular glue-like verteporfin induces IRE1α dimerization and activation to synergize with AKT inhibition in breast cancer
Liu, Y., Hua, H. M., Cao, Y., Li, M., Zhang, H., Du, S., Liu, J., Luo, T. L., & Jiang, Y. (2025) · Cell chemical biology · doi:10.1016/j.chembiol.2025.05.004 · Cited by 6
Methods to characterize and discover molecular degraders in cells
Lin, Z., & Woo, C. M. (2022) · Chemical Society Reviews · doi:10.1039/d2cs00261b · Cited by 7
TRI-611, a selective, brain-penetrant molecular glue degrader of ALK
Conery, A. R., La, D. S., Alekseyenko, A. A., Marcoux, D., Bart, A. G., Harlow, M. L., Arsenault, P. R., Cantone, N. R., Casaubon, R. L., Constan, A., et al. (2026) · Nature · doi:10.1038/s41586-026-10998-3 · Cited by 7
Leveraging high-throughput proteomics and AI-based protein folding to accelerate VAV1 molecular glue discovery
Lin, H., Yu, X., Haiyang, Cheng, R., Zhang, M., Qi, X., Yang, Y., Zhou, S., Qi, R., Le, L., et al. (2026) · Nature Communications · doi:10.1038/s41467-026-77657-z · Cited by 8
A Novel Paradigm for Targeting Challenging Targets: Advancing Technologies and Future Directions of Molecular Glue Degraders
Zhang, Y., Li, L., Xu, J., Che, C.-C., Jia, J., Lu, H., You, Q., & Xu, X. (2026) · Molecules · doi:10.3390/molecules31030459 · Cited by 4
A pharmacological modality to sequester homomeric proteins
Livnah, E., Suss, O., Rogel, A., Gilat, A., Abdan, Y., Villegas, J. A., Gabizon, R., Nadir, A., Shamir, Y., Steinman, N. Y., et al. (2026) · Nature Chemical Biology · doi:10.1038/s41589-026-02141-0 · Cited by 4
Experimental Conditions to Retrieve Intrinsic Cooperativity α Directly from Single Binding Assay Data Exemplified by the Ternary Complex Formation of FKBP12, MAPRE1 and Macrocyclic Molecular Glues
Schnatwinkel, J., Stein, R. R., Salcius, M., Wong, J. L., Chen, S., Fouché, M., & ROTH, H. ‐. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26072936 · Cited by 4
Comparative assessment of co-folding methods for molecular glue ternary structure predictionPreprint
Liao, Y., Zhu, J., Xie, J., Lai, L., & Pei, J. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.05.25.655997 · Cited by 4
Visible‐Light‐Controlled Lysine‐Selective Crosslinking Decodes Protein Complexes and Dynamic Interactomes in Live Cells
Xu, Y., Hu, H., Ran, Y., Zhao, W., Guo, A., Nie, H., Zhai, L., Yin, G., Cheng, J., Tao, S., et al. (2025) · Angewandte Chemie · doi:10.1002/ange.202507254 · Cited by 3
Clues for glues: from serendipity to nature’s blueprints in degrader discovery
Kozicka, Z. (2025) · Essays in Biochemistry · doi:10.1042/ebc20253058 · Cited by 5
Self-citation
Pan-cancer proteogenomic interrogation of the ubiquitin-proteasome system
González-Robles, T. J., Khan, M., Sastourne-Haletou, P., Triola, M., Zhou, H., Kito, Y., Kaisari, S., Fenyö, D., Róna, G., Soto‐Feliciano, Y. M., et al. (2026) · Cell Death and Differentiation · doi:10.1038/s41418-026-01787-6 · Cited by 3
Cross‐Linking Profiling of Molecular Glue Degrader‐Induced E3 Ligase Interactome to Expand Target Space
Xu, Y., Zhao, W., Nie, H., Wang, J., Fu, J., Hu, H., Liu, Z., Tao, S., Zhang, M., Zhou, Y., et al. (2025) · Angewandte Chemie · doi:10.1002/ange.202505053 · Cited by 3
A highly selective and orally bioavailable casein kinase 1 alpha degrader through p53 signaling pathway targets B-cell lymphoma cells
Feng, S., Kong, R., Wang, C., Hao, Q., Xie, X., Wang, H., Han, J., Zhang, Y., Elsner, J., Mendy, D., et al. (2025) · Leukemia · doi:10.1038/s41375-025-02647-x · Cited by 3
Mapping the global landscape of molecular glues in drug discovery: a bibliometric analysis from 2010 to 2024
Labhade, S., Bhole, R. P., Karwa, P. N., Kapare, H. S., & Singh, S. (2025) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-025-04630-w · Cited by 2
Human CTR1 Through the Ages: Milestones and Emerging Roles in Disease and Therapy
Peleg, S., Hofmann, L., & Ruthstein, S. (2025) · Biomolecules · doi:10.3390/biom15121739 · Cited by 2
Crystallographic fragment screening supports tool compound discovery and reveals conformational flexibility in human deoxyhypusine synthase
Wilk, P., Wątor, E., Muszak, D., Kochanowski, P., Krojer, T. J., & Grudnik, P. (2026) · Communications Chemistry · doi:10.1038/s42004-026-01897-9 · Cited by 2
Emerging biologic modalities for targeted protein degradation
Caldwell, A. G., Parmar, H., & Zhang, X. (2026) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2026.111248 · Cited by 2
Targeted Protein Degradation and Delivery Strategies in the Context of Neurological Disorders
Lu, H., Yang, Z., Kayumov, M., Wang, Y., Tang, F., Wang, X., Xia, T., Lei, T., Tong, F., & Gao, H. (2026) · ACS Nano · doi:10.1021/acsnano.6c04420 · Cited by 3
Targeted protein degradation: bridging chemical biology and clinical translation
Zhang, Y., Fu, J.-W., Liu, Y., Wu, R. Y., Liang, Y., Zhang, W., Yuan, T., Zhu, H., He, Q.-J., & Yang, B. (2026) · Acta Pharmacologica Sinica · doi:10.1038/s41401-026-01861-2 · Cited by 2
DCAF11-dependent molecular glue degrader activated by glutathionylation
Yoon, H., Wachter, F., Barrett, K., Jin, C., Rodríguez-Pöhnlein, A., Rutter, J. C., Lumpkin, R. J., Metivier, R. J., Donovan, K. A., Baek, K., et al. (2026) · Nature · doi:10.1038/s41586-026-10873-1 · Cited by 3
A dual MYC and GSPT1 protein degrader for MYC-driven hematologic malignancies
Nishida, Y., Impedovo, V., Ayoub, E., Baran, N., Scruggs, D. A., Hideaki, M., Khazaei, S., Ostermann, L. B., Kamachi, K., Zhang, L., et al. (2026) · Blood · doi:10.1182/blood.2025030170 · Cited by 2
RING dimerisation drives higher‐order organisation of SINA / SIAH E3 ubiquitin ligases
Coste, F., Mishra, A., Chapuis, C., Mance, L., Pukało, Z., Bigot, N., Goffinont, S., Gaudon, V., Garnier, N., Talhaoui, I., et al. (2025) · FEBS Journal · doi:10.1111/febs.70000 · Cited by 3
Insights and Future Perspectives of Covalent Protein Degraders
Zhang, X. (2022) · Wiley eBooks · doi:10.1002/9783527836208.ch8 · Cited by 2
Cellular Principles of Targeted Protein Degradation
Diamantino, J., & Hellerschmied, D. (2022) · Wiley eBooks · doi:10.1002/9783527836208.ch2 · Cited by 2
TF-MAPS: fast high-resolution functional and allosteric mapping of DNA-binding proteinsPreprint
Li, X., & Lehner, B. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.10.20.683418 · Cited by 2
Molecular Glues and Molecular Glue Degraders: Mechanisms, Design, and Therapeutic Applications
Shi, H. (2024) · Transactions on Materials Biotechnology and Life Sciences · doi:10.62051/r1m5q711 · Cited by 1
Targeted protein degradation for fetal hemoglobin induction: a new paradigm in β-hemoglobinopathy therapy
Arji, S., Shen, Z., Welch, S., ElMahdaoui, F., Bahadur, A., Lee, E., Lee, H., Wu, S.-C. P., Konshina, E., Ayubali, B., et al. (2026) · Biomarker Research · doi:10.1186/s40364-026-00911-5 · Cited by 1
A Scalable, Direct‐to‐Biology Platform for Accelerated Discovery of Cereblon‐Based Molecular Glue Degraders
Wang, J., Yin, G., Chi, Y., Feng, Y., Zhou, C., Nie, H., Zhang, Z., Meng, S., Chen, Y., Zhou, Z., et al. (2026) · Angewandte Chemie International Edition · doi:10.1002/anie.3518516 · Cited by 1
Covalent Molecular Glues: Mechanisms, Design Principles, and Emerging Therapeutic Opportunities in Targeted Protein Degradation
Al-Karmalawy, A. A., Attia, M. I., Yousef, T. A., Al-Qazzan, M. B., Al-Akeedi, M., Khatib, A. O. A., & Hawas, S. S. (2026) · Archiv der Pharmazie · doi:10.1002/ardp.70261 · Cited by 1
Molecular Glues Recruiting RNF213 As an E3 Ligase for Targeted Protein Degradation: A Minimal Dibromoacetamide Warhead As a Recruitment Ligand
Jiang, J., Chen, Y., Wan, R., Huang, C., Tao, X., Luo, C., Deng, J., Zhang, Z., Liu, T., Tan, Y., et al. (2026) · Journal of the American Chemical Society · doi:10.1021/jacs.6c03429 · Cited by 1
UbiDash: A UPS proteomic atlas for tissue-aware degrader design
González-Robles, T. J., Sastourne-Haletou, P., Triola, M., Khan, M., Bartha, Á., Estrada, J., Soto‐Feliciano, Y. M., Neel, B. G., Fenyö, D., Pagano, M., et al. (2026) · Cell Death and Differentiation · doi:10.1038/s41418-026-01791-w · Cited by 1
A deep dive into degrader-induced protein-protein interfaces
Galli, P., Pla‐Prats, C., & Thomä, N. H. (2023) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2023.02.001 · Cited by 1
Self-citation
Entdeckung eines potenten PROTAC ermöglicht die gezielte Ausschaltung der Gerüstfunktionen von FKBP51
Geiger, T. M., Walz, M., Meyners, C., Kuehn, A., Dreizler, J. K., Sugiarto, W. O., Maciel, E. V. S., Zheng, M., Lermyte, F., & Hausch, F. (2023) · Angewandte Chemie · doi:10.1002/ange.202309706 · Cited by 1
Targeted Protein Degradation – The Story So Far
O’Donovan, D. H., Luh, L. M., & Cromm, P. M. (2022) · Wiley eBooks · doi:10.1002/9783527836208.ch1 · Cited by 1
Visible-Light-Controlled Residue-Selective Cross-Linking for Deciphering Protein Complexes and Dynamic Protein-Protein Interactions in Live CellsPreprint
Xu, Y., Hu, H., Ran, Y., Zhao, W., Guo, A., Nie, H., Zhai, L., Yin, G.-L., Cheng, J., Tao, S., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.03.18.643847 · Cited by 1
A novel HERC4-dependent glue degrader targeting STINGPreprint
Mutlu, M., Schmidt, I., Morrison, A. I., Goretzki, B., Freuler, F., Begue, D., Pythoud, N., Ahrné, E., Kapps, S., Roest, S., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.02.08.527642
SMALL-MOLECULE DEGRADERS OF IKAROS ZINC FINGER (IKZF) TRANSCRIPTION FACTORS
Holmberg‐Douglas, N., Shunatona, H. P., Kumi, G. K., & Purandare, A. V. (2023) · Medicinal chemistry reviews · doi:10.1021/mc-2023-vol58.ch10
Gluing the pieces together
Kozicka, Z. (2023) · Science · doi:10.1126/science.adl4288
Self-citation
Fine-tuning chemical genetics to identify physiologic drug targets
Vostal, L. E., & Kapoor, T. M. (2023) · Cell chemical biology · doi:10.1016/j.chembiol.2023.10.017
Dual MYC and GSPT1 Protein Degrader for MYC-Driven CancersPreprint
Nishida, Y., Impedovo, V., Ayoub, E., Baran, N., Scruggs, D. A., Mizuno, H., Khazaei, S., Ostermann, L. B., Singh, S., Bedoy, A. D., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.04.24.650490
Rational Design of CDK12/13 and BRD4 Molecular Glue Degraders
Zhuang, Z., Byun, W. S., Kozicka, Z., Donovan, K. A., Dwyer, B. G., Thornhill, A. M., Jones, H. M., Jiang, Z., Zhu, X., Fischer, E. S., et al. (2025) · Angewandte Chemie · doi:10.1002/ange.202508427
Self-citation
Progress on molecular glue degraders
Chen, J., Deng, Z., Li, H., & Liu, L. (2025) · Scientia Sinica Chimica · doi:10.1360/ssc-2025-0228
Molecular Glue Degraders Redefining Targeted Therapies From Discovery to Therapeutic Applications
Wen, J., Yu, J., Wen, W., & Jiang, B. (2026) · MedComm – Oncology · doi:10.1002/mog2.70058
Indazolone-Based Molecular Glue Degraders as a Tunable Platform for Reprogramming Cereblon Substrate SpecificityPreprint
Nie, H., Wang, J., Xu, H., Zhou, Y.-J., Yin, G., Xu, X., Xu, G., Chen, B., Li, X., Hu, X., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.03.16.712139
Medicinal chemistry enabling advances in protein structure prediction
Munasinghe, A., Zhang, Z., & Wu, H. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-29808-0.00096-0
Targeting phase separation: a new strategy to disrupt the stromal-immune axis in colorectal cancer
Fu, C. Y., Chen, X., Yi, H., Huang, H., Zhang, L., Huang, H., Jiang, F., Lei, F., Yu, H., Liu, J., et al. (2026) · Cell Communication and Signaling · doi:10.1186/s12964-026-02849-5
A Scalable, Direct‐to‐Biology Platform for Accelerated Discovery of Cereblon‐Based Molecular Glue Degraders
Wang, J., Yin, G., Chi, Y., Feng, Y., Zhou, C., Nie, H., Zhang, Z., Meng, S., Chen, Y., Zhou, Z., et al. (2026) · Angewandte Chemie · doi:10.1002/ange.3518516
A Hypoxia-Activated Photomolecular Glue with Synergistic Cyclin K Degradation and Phototherapy for Cancer Treatment
Li, S., Tian, Z., Ma, Y., Lin, Y., Liu, H., Yang, J., & Wang, P. (2026) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.6c01039
Structural basis for selective and potent degradation of IRAK4 by KT-474
Fei, X., Ramanathan, A., Foley, C. A., Ford, M., Campbell, V., Zheng, X., Sintchak, M. D., Li, H., Kamadurai, H., Miller, R., et al. (2026) · Nature Communications · doi:10.1038/s41467-026-74105-w
Cells and Networks in Flux
Tykocinski, M. L. (2026) · American Journal Of Pathology · doi:10.1016/j.ajpath.2026.06.005
Drug Discovery of Allosteric Molecular Glue Degraders (aMGDs): Expanding the Landscape of Targeted Protein Degradation
Xue, Y., Ali, S., Chen, H., & Zhou, J. (2026) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.6c01988
Degraders of histone lysine methyltransferases: Progress, challenges, and opportunities
Yang, M., Zhang, Q., Yang, J., Cheng, R., & Zhou, X. (2026) · Drug Discovery Today · doi:10.1016/j.drudis.2026.104756
A scalable platform to discover and characterize substrates of molecular glue degraders
(2026) · Nature Biotechnology · doi:10.1038/s41587-026-03256-4
A Molecular Mechanistic Deep Dive into 14–3–3 Molecular Glue Cooperativity
Pennings, M. A. M., Vandenboorn-Bönner, E. M. F., Nooren, L., Konstantinidou, M., Altobelli, C. R., Ottmann, C., Markvoort, A. J., Miley, G. P., Arkin, M. R., & Brunsveld, L. (2026) · Biochemistry · doi:10.1021/acs.biochem.6c00427
A Sonochemically Activatable Pro‐Molecular Glue for Spatiotemporally Controlled Targeted Protein Degradation
Mu, Q., Wu, H., Peng, M., Chen, L., Tan, W., Li, H., Wang, Y., Xu, S., Sun, B., Li, R., et al. (2026) · Angewandte Chemie International Edition · doi:10.1002/anie.7024563 · Cited by 1
A Sonochemically Activatable Pro‐Molecular Glue for Spatiotemporally Controlled Targeted Protein Degradation
Mu, Q., Wu, H., Peng, M., Chen, L., Tan, W., Li, H., Wang, Y., Xu, S., Sun, B., Li, R., et al. (2026) · Angewandte Chemie · doi:10.1002/ange.7024563
A scalable, high-throughput glue perturbation screening platform for molecular glue discovery
Huang, D., Shuang, Z., Chen, L., Ouyang, H., Yang, P., Huang, L., Lu, W., Shi, M., Ding, X., Jiang, B., et al. (2026) · iScience · doi:10.1016/j.isci.2026.117600
BindingDB Entry 50022933: Discovery of a Potent and Selective GSPT1 Molecular Glue Degrader for the Treatment of Castration-Resistant Prostate Cancer.
BindingDB (2026) · UC San Diego · doi:10.7270/q270869b
BindingDB Entry 50019872: Expanding Chemical Probe Space: Quality Criteria for Covalent and Degrader Probes.
BindingDB (2024) · UC San Diego · doi:10.7270/q2gb28f9
BindingDB Entry 50018045: Natural Product-Inspired Targeted Protein Degraders: Advances and Perspectives.
BindingDB (2023) · UC San Diego · doi:10.7270/q2pv6qh4
BindingDB Entry 50018571: A Comprehensive Overview of Small-Molecule Androgen Receptor Degraders: Recent Progress and Future Perspectives.
BindingDB (2024) · UC San Diego · doi:10.7270/q2mw2ncq
BindingDB Entry 50019665: E3 Ligases Meet Their Match: Fragment-Based Approaches to Discover New E3 Ligands and to Unravel E3 Biology.
BindingDB (2024) · UC San Diego · doi:10.7270/q2sj1r0r
BindingDB Entry 50021508: Serendipitous discovery of Class I HDAC inhibitors from rational design of molecular glue degraders targeting HDAC.
BindingDB (2025) · UC San Diego · doi:10.7270/q22230df
BindingDB Entry 50016327: Selectivity through Targeted Protein Degradation (TPD).
BindingDB (2023) · UC San Diego · doi:10.7270/q22n568r
BindingDB Entry 50023159: Monoselective Histone Deacetylase 6 PROTAC Degrader Shows In Vivo Tractability.
BindingDB (2026) · UC San Diego · doi:10.7270/q2ff3z70
Sequence Scanning Improves Accuracy for Antibody–Antigen and Molecular Glue Ternary Complex Cofolding
Linker, S. M., Plötz, T., Evers, A., Müsil, D., Kaiser, J., & Schindler, C. (2026) · ChemMedChem · doi:10.1002/cmdc.70553

Authors: Kozicka, Z., & Thomä, N. H.
Affiliations: University of Basel (CH)
Friedrich Miescher Institute (CH)
Corresponding author: Thomä, Nicolas Holger
ORCID: Kozicka, Zuzanna
Thomä, Nicolas Holger
Venue: Cell Chemical Biology
Publisher: Elsevier BV
Published: 2021-07
Volume: 28
Issue: 7
Pages: 1032-1047
ISSN: 2451-9448 (ISSN-L)
2451-9456
DOI: 10.1016/j.chembiol.2021.04.009
OpenAlex: W3158527646
Semantic Scholar: ae8a5b956b209af205f68e27236708f9dc194e10
Cited by: 170
References: 111
Citations by year: 2026: 37 · 2025: 40 · 2024: 28 · 2023: 34 · 2022: 29 · 2021: 2
FWCI: 2.52
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 379 d)
doi.org/10.15223/policy-017 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-012 (stm-asf)
doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-004 (stm-asf)
Locations: Cell chemical biology (publishedVersion)
PubMed (publishedVersion)
Zenodo (CERN European Organization for Nuclear Research) (submittedVersion)
Funders: European Research Council (666068)
European Commission (765445)
Horizon 2020
Novartis Foundation
Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (186230, KFS-4980-02-2020)
Oncosuisse
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Degradation and Inhibitors
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ubiquitin and proteasome pathways
Physical Sciences › Chemistry › Organic Chemistry › Chemical Synthesis and Analysis
Keywords: molecular glues, E3 ubiquitin ligase, cullin-RING ubiquitin ligases, protein degradation, protein surface modification, protein-protein interaction, protein assembly, drug design, protein-protein interaction network
MeSH terms: Enzyme Inhibitors, Humans, Ubiquitin-Protein Ligases, Small Molecule Libraries, Ubiquitination

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Haven't got a glue: Protein surface variation for the design of molecular glue degraders

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks