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PFAS exposure and overweight/obesity among children in a nationally representative sample

Geiger, Sarah Dee, Yao, Ping, Vaughn, Michael G., Qian, Zhengmin·2021·Chemosphere
DOI 10.1016/j.chemosphere.2020.128852
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Abstract

Purpose Perfluoroalkyl substances (PFASs) are a class of manmade chemicals commonly used in consumer product manufacturing. Perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS) are two of the most highly studied PFASs. Both are present in the blood of the most Americans. PFASs are associated with intermediate cardiovascular disease (CVD) outcomes, but their relationship with obesity, a risk factor for intermediate and advanced CVD, remains largely unconfirmed. In this context, we aimed to explore the relationship between PFASs and both overweight/obesity and abdominal obesity among children. Methods We examine associations between PFOA and PFOS levels, and Body Mass Index (BMI) and waist circumference (WC) in a representative sample (N = 2473) of US children, aged 12-18 years from the Centers for Disease Control and Prevention's National Health and Nutrition Examination Survey 1999-2012. Overweight/obesity is defined as age-, sex-specific BMI z-score ≥ 85th percentile; abdominal obesity is defined as age-, sex-specific waist circumference ≥90th percentile. Results Associations between PFASs and anthropometric outcomes show a dose-response relationship overall. For overweight/obese BMI z-score, findings indicate OR = 1.42 and 95% CI: 0.85-2.38 for quartile 2 of PFOA exposure; OR = 2.22 (95% CI: 1.20-4.13) for quartile 3 of PFOA exposure; and OR = 2.73 (95% CI:1.10-6.74) for quartile 4 of PFOA exposure. Discussion Findings indicate an association between elevated…

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Research works printed but not linked: 27

  1. Andersen, 2010, Prenatal exposures to perfluorinated chemicals and anthropometric measures in infancy, Am. J. Epidemiol., 172, 1230, 10.1093/aje/kwq289 · DOI
  2. Andersen, 2013, Prenatal exposures to perfluorinated chemicals and anthropometry at 7 years of age, Am. J. Epidemiol., 178, 921, 10.1093/aje/kwt057 · DOI
  3. Apelberg, 2007, Cord serum concentrations of perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA) in relation to weight and size at birth, Environ. Health Perspect., 115, 1670, 10.1289/ehp.10334 · DOI
  4. Bhandari, 2013, Urinary bisphenol A and obesity in U.S. children, Am. J. Epidemiol., 177, 1263, 10.1093/aje/kws391 · DOI
  5. Calafat, 2007, Polyfluoroalkyl chemicals in the U.S. Population: data from the national health and nutrition examination survey (NHANES) 2003-2004 and comparisons with NHANES 1999-2000, Environ. Health Perspect., 115, 1596, 10.1289/ehp.10598 · DOI · Paper page
  6. Chen, 2012, Perfluorinated compounds in umbilical cord blood and adverse birth outcomes, PloS One, 7
  7. Cook, 2003, Prevalence of a metabolic syndrome phenotype in adolescents: findings from the third National Health and Nutrition Examination Survey, 1988-1994, Arch. Pediatr. Adolesc. Med., 157, 821, 10.1001/archpedi.157.8.821 · DOI · Paper page
  8. Fei, 2007, Perfluorinated chemicals and fetal growth: a study within the Danish national birth cohort, Environ. Health Perspect., 115, 1677, 10.1289/ehp.10506 · DOI
  9. Fei, 2008, J. Fetal growth indicators and perfluorinated chemicals: a study in the Danish national birth cohort, Am. J. Epidemiol., 168, 66, 10.1093/aje/kwn095 · DOI
  10. Feig, 2003, Hyperuricemia in childhood primary hypertension, Hypertension, 42, 247, 10.1161/01.HYP.0000085858.66548.59 · DOI
  11. Fernández, 2004, Waist circumference percentiles in nationally representative samples of African-American, European-American, and Mexican-American children and adolescents, J. Pediatr., 145, 439, 10.1016/j.jpeds.2004.06.044 · DOI
  12. Frayn, 2003, Integrative physiology of human adipose tissue, Int. J. Obes. Relat. Metab. Disord. J. Int. Assoc. Study Obes., 27, 875, 10.1038/sj.ijo.0802326 · DOI
  13. Geiger, 2013, Positive association between perfluoroalkyl chemicals and hyperuricemia in children, Am. J. Epidemiol., 177, 1255, 10.1093/aje/kws392 · DOI
  14. Geiger, 2013, Positive association between perfluoroalkyl chemicals and hyperuricemia in children, Am. J. Epidemiol., 177, 1255, 10.1093/aje/kws392 · DOI
  15. Geiger, 2014, The association between PFOA, PFOS and serum lipid levels in adolescents, Chemosphere, 98, 78, 10.1016/j.chemosphere.2013.10.005 · DOI
  16. Hirschler, 2005, Can waist circumference identify children with the metabolic syndrome?, Arch. Pediatr. Adolesc. Med., 159, 740, 10.1001/archpedi.159.8.740 · DOI
  17. Lauritzen, 2018, Prenatal exposure to persistent organic pollutants and child overweight/obesity at 5-year follow-up: a prospective cohort study, Environ. Health Glob. Access Sci. Source, 17, 9
  18. Lee, 2016, Is the 90th percentile adequate? The optimal waist circumference cutoff points for predicting cardiovascular risks in 124,643 15-Year-Old Taiwanese adolescents, PloS One, 11
  19. Li, 2018, Half-lives of PFOS, PFHxS and PFOA after end of exposure to contaminated drinking water, Occup. Environ. Med., 75, 46, 10.1136/oemed-2017-104651 · DOI · Paper page
  20. Nadeau, 2011, Childhood obesity and cardiovascular disease: links and prevention strategies, Nat. Rev. Cardiol., 8, 513, 10.1038/nrcardio.2011.86 · DOI
  21. Shrier, 2008, Reducing bias through directed acyclic graphs, BMC Med. Res. Methodol., 8, 70, 10.1186/1471-2288-8-70 · DOI
  22. Steenland, 2010, Epidemiologic evidence on the health effects of perfluorooctanoic acid (PFOA), Environ. Health Perspect., 118, 1100, 10.1289/ehp.0901827 · DOI · Paper page
  23. Steenland, 2010, Epidemiologic evidence on the health effects of perfluorooctanoic acid (PFOA), Environ. Health Perspect., 118, 1100, 10.1289/ehp.0901827 · DOI · Paper page
  24. Sunderland, 2019, A review of the pathways of human exposure to poly- and perfluoroalkyl substances (PFASs) and present understanding of health effects, J. Expo. Sci. Environ. Epidemiol., 29, 131, 10.1038/s41370-018-0094-1 · DOI · Paper page
  25. Thompson, 2007, Childhood overweight and cardiovascular disease risk factors: the national heart, lung, and blood Institute growth and health study, J. Pediatr., 150, 18, 10.1016/j.jpeds.2006.09.039 · DOI
  26. Trasande, 2012, Association between urinary bisphenol A concentration and obesity prevalence in children and adolescents, Jama, 308, 1113, 10.1001/2012.jama.11461 · DOI
  27. Wang, 2006, Worldwide trends in childhood overweight and obesity, Int. J. Pediatr. Obes. IJPO Off. J. Int. Assoc. Study Obes., 1, 11

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Metadata

Authors
Geiger, S. D., Yao, P., Vaughn, M. G., & Qian, Z.
Venue
Chemosphere
Publisher
Elsevier BV
Published
2021-04
Volume
268
Pages
128852
ISSN
0045-6535
DOI
10.1016/j.chemosphere.2020.128852
Cited by
100
References
3
Language
en
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CoChat. (2026). Citation check: PFAS exposure and overweight/obesity among children in a nationally representative sample. https://app.cochat.ai/papers/10.1016/j.chemosphere.2020.128852
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Geiger, S. D., Yao, P., Vaughn, M. G., & Qian, Z. (2021). PFAS exposure and overweight/obesity among children in a nationally representative sample. Chemosphere. https://doi.org/10.1016/j.chemosphere.2020.128852