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Defining Extreme Phenotypes of OSA Across International Sleep Centers
Open accessAbstract
BACKGROUND We developed objective definitions of extreme phenotypes of obstructive sleep apnea (OSA) using a multivariate approach, and demonstrate their utility for identifying characteristics that confer predisposition towards or protection against OSA in a new prospective sample. METHODS In a large international sample, we calculated race-specific liability scores from a weighted logistic regression including age, gender and body mass index (BMI). Extreme Cases were defined as individuals with an apnea-hypopnea index (AHI) ≥30 events/hour, but low likelihood of OSA based on age, gender and BMI (liability scores >90th percentile). Similarly, Extreme Controls were individuals with AHI<5, but high likelihood of OSA (liability scores <10th percentile). Definitions were applied to a prospective sample from the Sleep Apnea Global Interdisciplinary Consortium (SAGIC) and differences in photography-based craniofacial and intraoral phenotypes evaluated. RESULTS Retrospective data included 81,338 individuals. We identified 4,168 Extreme Cases and 1,432 Extreme Controls using liability scores. Extreme Cases were younger (43.1±14.7 years), overweight (28.6±6.8 kg/m2), and predominantly female (71.1%). Extreme Controls were older (53.8±14.1 years), obese (34.0±8.1 kg/m2), and predominantly male (65.8%). These objective definitions identified 29 Extreme Cases and 87 Extreme Controls among 1,424 SAGIC participants with photography-based phenotyping; comparisons suggest greater cervicomental angle increases risk for OSA in the absence of clinical risk factors and smaller facial widths are protective in the presence of clinical risk factors. CONCLUSIONS This objective definition can be applied in sleep centers throughout the world to consistently define OSA extreme phenotypes for future studies on genetic, anatomic and physiological pathways to OSA.
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Extreme phenotypes of OSA have been demonstrated.
“Extreme phenotypes have been demonstrated.256”
From International Consensus Statement on Obstructive Sleep Apnea (2023) · cites this paper as [256]
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Metadata
- Authors
- Rizzatti, F. G., Mazzotti, D. R., Mindel, J., Maislin, G., Keenan, B. T., Bittencourt, L., Chen, N.-H., Cistulli, P. A., McArdle, N., Pack, F. M., Singh, B., Sutherland, K., Benediktsdottir, B., Fietze, I., Gislason, T., Lim, D. C., Penzel, T., Sanner, B., Han, F., Li, Q. Y., Schwab, R., Tufik, S., Pack, A. I., & Magalang, U. J.
- Affiliations
- Universidade Federal de São Carlos (BR)
- University of Pennsylvania (US)
- The Ohio State University Wexner Medical Center (US)
- Universidade Federal de São Paulo (BR)
- Chang Gung Memorial Hospital (TW)
- The University of Sydney (AU)
- Sir Charles Gairdner Hospital (AU)
- Charité – Universitätsmedizin Berlin (DE)
- Saratov State University (RU)
- Agaplesion Bethesda Krankenhaus (DE)
- Peking University (CN)
- Shanghai Jiao Tong University (CN)
- Corresponding author
- Magalang, Ulysses J.
- ORCID
- Venue
- Chest
- Publisher
- Elsevier BV
- Published
- 2020-09
- Volume
- 158
- Issue
- 3
- Pages
- 1187-1197
- ISSN
- 0012-3692 (ISSN-L)
- PMC
- PMC7478234
- OpenAlex
- W3017103078
- Semantic Scholar
- f06f8982f2b91a4105dd5fe4f2b4a98e5e2bcec5
- Cited by
- 19
- References
- 36
- Citations by year
- 2025: 2 · 2024: 2 · 2023: 5 · 2022: 7 · 2021: 3
- FWCI
- 2.26
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- CHEST Journal (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Hirsla (Landspítali University Hospital) (submittedVersion)
- Funders
- Conselho Nacional de Desenvolvimento Científico e Tecnológico (401569/2016-0)
- National Institutes of Health (P01 HL094307)
- National Center for Advancing Translational Sciences (UL1TR001070)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Obstructive Sleep Apnea Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Health Sciences › Dentistry › Oral Surgery › Temporomandibular Joint Disorders
- Keywords
- obstructive sleep apnea, extreme phenotypes, apnea-hypopnea index, craniofacial morphology, cervicomental angle, facial width, obesity, sex differences, genetic susceptibility
- MeSH terms
- Adult, Age Factors, Aged, Female, Humans, Male, Middle Aged, Phenotype, Photography, Retrospective Studies, Risk Factors, Sex Factors, Sleep Apnea, Obstructive, Internationality
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