The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.
The Ability of Primate Lentiviruses to Degrade the Monocyte Restriction Factor SAMHD1 Preceded the Birth of the Viral Accessory Protein Vpx
Open accessAbstract
The human SAMHD1 protein potently restricts lentiviral infection in dendritic cells and monocyte/macrophages, but is antagonized by the primate lentiviral protein Vpx which targets SAMHD1for degradation. However, only two of eight primate lentivirus lineages encode Vpx whereas its paralog, Vpr, is conserved across all extant primate lentiviruses. We find that not only multiple Vpx but also some Vpr proteins are able to degrade SAMHD1 and such antagonism led to dramatic positive selection of SAMHD1 in the primate subfamily Cercopithecinae. Residues that have evolved under positive selection precisely determine sensitivity to Vpx/Vpr degradation and alter binding specificity. By overlaying these functional analyses on a phylogenetic framework of Vpr and Vpx evolution, we can decipher the chronology of acquisition of SAMHD1-degrading abilities in lentiviruses. We conclude that vpr neofunctionalized to degrade SAMHD1 even prior to the birth of a separate vpx gene, thereby initiating an evolutionary arms race with SAMHD1.
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Cites
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SAMHD1 is the dendritic- and myeloid-cell-specific HIV-1 restriction factor counteracted by Vpx
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“The phylogeny constructed from the primate SAMHD1 sequences was congruent with the generally accepted primate species phylogeny (Perelman et al., 2011), confirming that the sequences are orthologous.”
Trex1 prevents cell-intrinsic initiation of autoimmunity
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“Binding of Diverse Vprs to SAMHD1 Correlates with Degradation Previous studies have shown that Vpx from SIVsm and HIV-2 are able to bind SAMHD1 directly in order to promote its degradation (Hrecka et al., 2011; Laguette et al., 2011).”
InfluentialHIV-1 restriction factor SAMHD1 is a deoxynucleoside triphosphate triphosphohydrolase
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Cited by
Rules of engagement: molecular insights from host–virus arms races
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Self-citationThe enemy within: endogenous retroelements and autoimmune disease
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Dual host–virus arms races shape an essential housekeeping protein
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HIV-1 and HIV-2 exhibit divergent interactions with HLTF and UNG2 DNA repair proteins
Hrecka, K., Hao, C., Shun, M.-C., Kaur, S., Swanson, S. K., Florens, L., Washburn, M. P., & Skowronski, J. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1605023113 · Cited by 80
Rapid evolution of BRCA1 and BRCA2in humans and other primates
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Metadata
- Authors
- Lim, E. S., Fregoso, O. I., McCoy, C. O., Matsen, F. A., Malik, H. S., & Emerman, M.
- Venue
- Cell Host & Microbe
- Publisher
- Elsevier BV
- Published
- 2012-02
- Volume
- 11
- Issue
- 2
- Pages
- 194-204
- ISSN
- 1931-3128 (ISSN-L)
- OpenAlex
- W2021736427
- Cited by
- 261
- References
- 43
- FWCI
- 18.05
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Lim, E. S., Fregoso, O. I., McCoy, C. O., Matsen, F. A., Malik, H. S., & Emerman, M. (2012). The Ability of Primate Lentiviruses to Degrade the Monocyte Restriction Factor SAMHD1 Preceded the Birth of the Viral Accessory Protein Vpx. Cell Host & Microbe. https://doi.org/10.1016/j.chom.2012.01.004
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