The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Dynamic Oscillation of Translation and Stress Granule Formation Mark the Cellular Response to Virus Infection
Open accessAbstract
SUMMARY Virus infection-induced global protein synthesis suppression is linked to assembly of stress granules (SGs), cytosolic aggregates of stalled translation preinitiation complexes. To study long-term stress responses, we developed an imaging approach for extended observation and analysis of SG dynamics during persistent hepatitis C virus (HCV) infection. In combination with type 1 interferon, HCV infection induces highly dynamic assembly/disassembly of cytoplasmic SGs, concomitant with phases of active and stalled translation, delayed cell division, and prolonged cell survival. Double-stranded RNA (dsRNA), independent of viral replication, is sufficient to trigger these oscillations. Translation initiation factor eIF2α phosphorylation by protein kinase R mediates SG formation and translation arrest. This is antagonized by the upregulation of GADD34, the regulatory subunit of protein phosphatase 1 dephosphorylating eIF2α. Stress response oscillation is a general mechanism to prevent long-lasting translation repression and a conserved host cell reaction to multiple RNA viruses, which HCV may exploit to establish persistence.
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The dsRNA protein kinase PKR: Virus and cell control
García, M. A., Meurs, E. F., & Esteban, M. (2007) · Biochimie · doi:10.1016/j.biochi.2007.03.001 · Cited by 644
Cited by
Immunogenic cell stress and death
Kroemer, G., Galassi, C., Zitvogel, L., & Galluzzi, L. (2022) · Nature Immunology · doi:10.1038/s41590-022-01132-2 · Cited by 1,353
Continuous and Discontinuous RNA Synthesis in Coronaviruses
Sola, I., Almazán, F., Zúñiga, S., & Enjuanes, L. (2015) · Annual Review of Virology · doi:10.1146/annurev-virology-100114-055218 · Cited by 643
Temporal control of the integrated stress response by a stochastic molecular switch
Klein, P., Kallenberger, S. M., Roth, H., Roth, K., Ly-Hartig, T. B. N., Magg, V., Aleš, J., Talemi, S. R., Qiang, Y., Wolf, S., et al. (2022) · Science Advances · doi:10.1126/sciadv.abk2022 · Cited by 50
Self-citationYan, Y., Shetty, M., Harding, H. P., George, G., Zyryanova, A., Labbé, K., Mafi, A., Hao, Q., Sidrauski, C., & Ron, D. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2320013121 · Cited by 7
Metadata
- Authors
- Ruggieri, A., Dazert, E., Metz, P., Hofmann, S., Bergeest, J.-P., Mazur, J., Bankhead, P., Hiet, M.-S., Kallis, S., Alvisi, G., Samuel, C. E., Lohmann, V., Kaderali, L., Rohr, K., Frese, M., Stoecklin, G., & Bartenschlager, R.
- Venue
- Cell Host & Microbe
- Publisher
- Elsevier BV
- Published
- 2012-07
- Volume
- 12
- Issue
- 1
- Pages
- 71-85
- ISSN
- 1931-3128 (ISSN-L)
- OpenAlex
- W2065148518
- Cited by
- 179
- References
- 1
- FWCI
- 6.16
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Ruggieri, A., Dazert, E., Metz, P., Hofmann, S., Bergeest, J.-P., Mazur, J., Bankhead, P., Hiet, M.-S., Kallis, S., Alvisi, G., Samuel, C. E., Lohmann, V., Kaderali, L., Rohr, K., Frese, M., Stoecklin, G., & Bartenschlager, R. (2012). Dynamic Oscillation of Translation and Stress Granule Formation Mark the Cellular Response to Virus Infection. Cell Host & Microbe. https://doi.org/10.1016/j.chom.2012.05.013
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