The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
A Secreted Bacterial Protease Tailors the Staphylococcus aureus Virulence Repertoire to Modulate Bone Remodeling during Osteomyelitis
Open accessAbstract
Summary Osteomyelitis is a common manifestation of invasive Staphylococcus aureus infection. Pathogen-induced bone destruction limits antimicrobial penetration to the infectious focus and compromises treatment of osteomyelitis. To investigate mechanisms of S. aureus-induced bone destruction, we developed a murine model of osteomyelitis. Micro-computed tomography of infected femurs revealed that S. aureus triggers profound alterations in bone turnover. The bacterial regulatory locus sae was found to be critical for osteomyelitis pathogenesis, as Sae-regulated factors promote pathologic bone remodeling and intraosseous bacterial survival. Exoproteome analyses revealed the Sae-regulated protease aureolysin as a major determinant of the S. aureus secretome and identified the phenol soluble modulins as aureolysin-degraded, osteolytic peptides that trigger osteoblast cell death and bone destruction. These studies establish a murine model for pathogen-induced bone remodeling, define Sae as critical for osteomyelitis pathogenesis, and identify protease-dependent exoproteome remodeling as a major determinant of the staphylococcal virulence repertoire.
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Wang, R., Braughton, K. R., Kretschmer, D., Bach, T.-H. L., Queck, S. Y., Li, M., Kennedy, A. D., Dorward, D. W., Klebanoff, S. J., Peschel, A., et al. (2007) · Nature Medicine · doi:10.1038/nm1656 · Cited by 1,046
Passage of Heme-Iron Across the Envelope of Staphylococcus aureus
Mazmanian, S. K., Skaar, E. P., Gaspar, A. H., Humayun, M., Gornicki, P., Jelenska, J., Joachmiak, A., Missiakas, D. M., & Schneewind, O. (2003) · Science · doi:10.1126/science.1081147 · Cited by 593
Self-citationEvolution of virulence in epidemic community-associated methicillin-resistant Staphylococcus aureus
Li, M., Diep, B. A., Villaruz, A. E., Braughton, K. R., Jiang, X., DeLeo, F. R., Chambers, H. F., Lu, Y., & Otto, M. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0900743106 · Cited by 394 · cited 2×
“…as USA300 lineage strains of S. aureus are characterized by enhanced production of PSMs relative to other S. aureus clinical strain lineages (Li et al., 2009), our results may partially explain the increased morbidity associated with USA300 strains in patients with osteomyelitis…”
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Cited by
Quorum-sensing regulation in staphylococci—an overview
Le, K. Y., & Otto, M. (2015) · Frontiers in Microbiology · doi:10.3389/fmicb.2015.01174 · Cited by 490
Staphylococcus aureus Secreted Toxins and Extracellular Enzymes
Tam, K., & Torres, V. J. (2019) · Microbiology Spectrum · doi:10.1128/microbiolspec.gpp3-0039-2018 · Cited by 452
Self-citationHammer, N. D., Cassat, J. E., Noto, M. J., Lojek, L. J., Chadha, A. D., Schmitz, J. E., Creech, C. B., & Skaar, E. P. (2014) · Cell Host & Microbe · doi:10.1016/j.chom.2014.09.002 · Cited by 72
Potter, A. D., Butrico, C. E., Ford, C. A., Curry, J. M., Trenary, I. A., Tummarakota, S. S., Hendrix, A. S., Young, J. D., & Cassat, J. E. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1922211117 · Cited by 73
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Metadata
- Authors
- Cassat, J. E., Hammer, N. D., Campbell, J. P., Benson, M. A., Perrien, D. S., Mrak, L. N., Smeltzer, M. S., Torres, V. J., & Skaar, E. P.
- Venue
- Cell Host & Microbe
- Publisher
- Elsevier BV
- Published
- 2013-06
- Volume
- 13
- Issue
- 6
- Pages
- 759-772
- ISSN
- 1931-3128 (ISSN-L)
- OpenAlex
- W2091015771
- Cited by
- 248
- References
- 3
- FWCI
- 11.89
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Cassat, J. E., Hammer, N. D., Campbell, J. P., Benson, M. A., Perrien, D. S., Mrak, L. N., Smeltzer, M. S., Torres, V. J., & Skaar, E. P. (2013). A Secreted Bacterial Protease Tailors the Staphylococcus aureus Virulence Repertoire to Modulate Bone Remodeling during Osteomyelitis. Cell Host & Microbe. https://doi.org/10.1016/j.chom.2013.05.003
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
