The DOI matches its Crossref record; 97 of the 97 references it cites were found in a registry or an index.
Quorum-sensing regulation in staphylococci—an overview
Open accessAbstract
Staphylococci are frequent human commensals and some species can cause disease. Staphylococcus aureus in particular is a dangerous human pathogen. In staphylococci, the ability to sense the bacterial cell density, or quorum, and to respond with genetic adaptations is due to one main system, which is called accessory gene regulator (Agr). The extracellular signal of Agr is a post-translationally modified peptide containing a thiolactone structure. Under conditions of high cell density, Agr is responsible for the increased expression of many toxins and degradative exoenzymes, and decreased expression of several colonization factors. This regulation is important for the timing of virulence factor expression during infection and the development of acute disease, while low activity of Agr is associated with chronic staphylococcal infections, such as those involving biofilm formation. Accordingly, drugs inhibiting Agr are being evaluated for their capacity to control acute forms of S. aureus infection.
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Cites
Staphylococcus aureus Infections
Lowy, F. D. (1998) · New England Journal of Medicine · doi:10.1056/nejm199808203390806 · Cited by 6,005
QUORUM SENSING: Cell-to-Cell Communication in Bacteria
Waters, C. M., & Bassler, B. L. (2005) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.21.012704.131001 · Cited by 3,979
Staphylococcus epidermidis — the 'accidental' pathogen
Otto, M. (2009) · Nature Reviews Microbiology · doi:10.1038/nrmicro2182 · Cited by 1,808
Self-citationStructural identification of a bacterial quorum-sensing signal containing boron
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Synthesis of staphylococcal virulence factors is controlled by a regulatory RNA molecule.
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Self-citationQuorum Sensing in Staphylococci
Novick, R. P., & Geisinger, E. (2008) · Annual Review of Genetics · doi:10.1146/annurev.genet.42.110807.091640 · Cited by 958
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Self-citationBacterial Interference Caused by Autoinducing Peptide Variants
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Cited by
Pathogenicity and virulence of Staphylococcus aureus
Cheung, G. Y. C., Bae, J. S., & Otto, M. (2021) · Virulence · doi:10.1080/21505594.2021.1878688 · Cited by 1,380
Self-citationSkeletal infections: microbial pathogenesis, immunity and clinical management
Masters, E. A., Ricciardi, B. F., Bentley, K. L. D. M., Moriarty, T. F., Schwarz, E. M., & Muthukrishnan, G. (2022) · Nature Reviews Microbiology · doi:10.1038/s41579-022-00686-0 · Cited by 735
Microbe-host interplay in atopic dermatitis and psoriasis
Fyhrquist, N., Muirhead, G., Prast-Nielsen, S., Jeanmougin, M., Olah, P., Skoog, T., Jules-Clement, G., Feld, M., Barrientos-Somarribas, M., Sinkko, H., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-12253-y · Cited by 409
Fournière, M., Latire, T., Souak, D., Feuilloley, M. G. J., & Bedoux, G. (2020) · Microorganisms · doi:10.3390/microorganisms8111752 · Cited by 227
The role of RNA regulators, quorum sensing and c‐di‐GMP in bacterial biofilm formation
Condinho, M., Carvalho, B., Cruz, A., Pinto, S. N., Arraiano, C. M., & Pobre, V. (2023) · FEBS Open Bio · doi:10.1002/2211-5463.13389 · Cited by 64
Metadata
- Authors
- Le, K. Y., & Otto, M.
- Venue
- Frontiers in Microbiology
- Publisher
- Frontiers Media SA
- Published
- 2015-10-27
- Volume
- 6
- Pages
- 1174-1174
- ISSN
- 1664-302X (ISSN-L)
- OpenAlex
- W2201809605
- Cited by
- 490
- References
- 97
- FWCI
- 7.98
- Type
- journal article
- Language
- en
- Open access
- gold
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
