The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
A View to a Kill: The Bacterial Type VI Secretion System
Open accessAbstract
The bacterial Type 6 Secretion System (T6SS) is an organelle that is structurally and mechanistically analogous to an intracellular membrane-attached contractile phage tail. Recent studies determined that a rapid conformational change in the structure of a sheath protein complex propels T6SS spike and tube components along with anti-bacterial and anti-eukaryotic effectors out of predatory T6SS+ cells and into prey cells. The contracted organelle is then recycled in an ATP-dependent process. T6SS is regulated at transcriptional and post-translational levels, the latter involving detection of membrane perturbation in some species. In addition to directly targeting eukaryotic cells, the T6SS can also target other bacteria co-infecting a mammalian host, highlighting the importance of the T6SS not only for bacterial survival in environmental ecosystems but also in the context of infection and disease. This review highlights these and other advances in our understanding of the structure, mechanical function, assembly, and regulation of the T6SS.
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Cites
Oral multispecies biofilm development and the key role of cell–cell distance
Kolenbrander, P. E., Palmer, R. J., Periasamy, S., & Jakubovics, N. S. (2010) · Nature Reviews Microbiology · doi:10.1038/nrmicro2381 · Cited by 1,309
Cited by
Garrett, W. S. (2015) · Science · doi:10.1126/science.aaa4972 · Cited by 1,404
Secretion systems in Gram-negative bacteria: Structural and mechanistic insights
Costa, T. R. D., Felisberto-Rodrigues, C., Meir, A., Prevost, M. S., Redzej, A., Trokter, M., & Waksman, G. (2015) · Nature Reviews Microbiology · doi:10.1038/nrmicro3456 · Cited by 1,132
Architecture and assembly of the Type VI secretion system
Zoued, A., Brunet, Y. R., Durand, E., Aschtgen, M.-S., Logger, L., Douzi, B., Journet, L., Cambillau, C., & Cascales, E. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2014.03.018 · Cited by 259
Si, M., Zhao, C., Burkinshaw, B., Zhang, B., Wei, D., Wang, Y., Dong, T. G., & Shen, X. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1614902114 · Cited by 245
Self-citationHow a natural antibiotic uses oxidative stress to kill oxidant-resistant bacteria
Gupta, A., & Imlay, J. A. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2312110120 · Cited by 34
Metadata
- Authors
- Ho, B. T., Dong, T. G., & Mekalanos, J. J.
- Venue
- Cell Host & Microbe
- Publisher
- Elsevier BV
- Published
- 2014-01
- Volume
- 15
- Issue
- 1
- Pages
- 9-21
- ISSN
- 1931-3128 (ISSN-L)
- OpenAlex
- W2122095711
- Cited by
- 639
- References
- 1
- FWCI
- 23.67
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Ho, B. T., Dong, T. G., & Mekalanos, J. J. (2014). A View to a Kill: The Bacterial Type VI Secretion System. Cell Host & Microbe. https://doi.org/10.1016/j.chom.2013.11.008
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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