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Cited by 177Neutrophil, Myeloperoxidase and Oxidative MechanismsRedox biology and oxidative stressSalmonella and Campylobacter epidemiology

The DOI matches its Crossref record; 77 of the 77 references it cites were found in a registry or an index.

Disparate Impact of Oxidative Host Defenses Determines the Fate of Salmonella during Systemic Infection in Mice

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Burton, Neil A., Schürmann, Nura, Casse, Olivier, Steeb, Anne K., Claudi, Beatrice, Zankl, Janine, Schmidt, Alexander, Bumann, Dirk·2014·Cell Host & Microbe
DOI 10.1016/j.chom.2013.12.006
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Abstract

Reactive oxygen and nitrogen species function in host defense via mechanisms that remain controversial. Pathogens might encounter varying levels of these species, but bulk measurements cannot resolve such heterogeneity. We used single-cell approaches to determine the impact of oxidative and nitrosative stresses on individual Salmonella during early infection in mouse spleen. Salmonella encounter and respond to both stresses, but the levels and impact vary widely. Neutrophils and inflammatory monocytes kill Salmonella by generating overwhelming oxidative stress through NADPH oxidase and myeloperoxidase. This controls Salmonella within inflammatory lesions but does not prevent their spread to more permissive resident red pulp macrophages, which generate only sublethal oxidative bursts. Regional host expression of inducible nitric oxide synthase exposes some Salmonella to nitrosative stress, triggering effective local Salmonella detoxification through nitric oxide denitrosylase. Thus, reactive oxygen and nitrogen species influence dramatically different outcomes of disparate Salmonella-host cell encounters, which together determine overall disease progression.

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Metadata

Authors
Burton, N. A., Schürmann, N., Casse, O., Steeb, A. K., Claudi, B., Zankl, J., Schmidt, A., & Bumann, D.
Affiliations
University of Basel (CH)
Corresponding author
Bumann, Dirk
ORCID
Venue
Cell Host & Microbe
Publisher
Elsevier BV
Published
2014-01
Volume
15
Issue
1
Pages
72-83
ISSN
1931-3128 (ISSN-L)
DOI
10.1016/j.chom.2013.12.006
OpenAlex
W2034408518
Cited by
175
References
77
Citations by year
2026: 8 · 2025: 13 · 2024: 13 · 2023: 9 · 2022: 11 · 2021: 15 · 2020: 17 · 2019: 17 · 2018: 9 · 2017: 19 · 2016: 15 · 2015: 19 · 2014: 10
FWCI
9.59
Type
journal article
Language
en
Open access
Licence
Locations
  • Cell Host & Microbe (publishedVersion)
  • PubMed (publishedVersion)
Funders
Deutsche Forschungsgemeinschaft (SPP 1316)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Salmonella and Campylobacter epidemiology
Keywords
Salmonella, reactive oxygen species, reactive nitrogen species, oxidative stress, nitrosative stress, host-pathogen interaction, neutrophils, inflammatory monocytes, NADPH oxidase, myeloperoxidase, red pulp macrophages, inducible nitric oxide synthase, single-cell tracking, systemic infection, spleen, mouse model
MeSH terms
Animals, Female, Macrophages, Monocytes, Peroxidase, Neutrophils, Oxygenases, Salmonella Infections, Salmonella typhimurium, Spleen, Gene Expression, Respiratory Burst, Reactive Oxygen Species, NADPH Oxidases, Reactive Nitrogen Species, Mice, Nitric Oxide Synthase Type II, Host-Pathogen Interactions, Single-Cell Analysis

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