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The FLS2-Associated Kinase BIK1 Directly Phosphorylates the NADPH Oxidase RbohD to Control Plant Immunity
Open accessAbstract
The Arabidopsis immune receptor FLS2 senses the bacterial flagellin epitope flg22 to activate transient elevation of cytosolic calcium ions, production of reactive oxygen species (ROS), and other signaling events to coordinate antimicrobial defenses, such as stomatal closure that limits bacterial invasion. However, how FLS2 regulates these signaling events remains largely unknown. Here we show that the receptor-like cytoplasmic kinase BIK1, a component of the FLS2 immune receptor complex, not only positively regulates flg22-triggered calcium influx but also directly phosphorylates the NADPH oxidase RbohD at specific sites in a calcium-independent manner to enhance ROS generation. Furthermore, BIK1 and RbohD form a pathway that controls stomatal movement in response to flg22, thereby restricting bacterial entry into leaf tissues. These findings highlight a direct role of the FLS2 complex in the regulation of RbohD-mediated ROS production and stomatal defense.
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Cited by
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Yuan, M., Jiang, Z., Bi, G., Nomura, K., Liu, M., Wang, Y., Cai, B., Zhou, J.-M., He, S. Y., & Xin, X.-F. (2021) · Nature · doi:10.1038/s41586-021-03316-6 · Cited by 1,257
Self-citationPTI-ETI crosstalk: an integrative view of plant immunity
Yuan, M., Ngou, B. P. M., Ding, P., & Xin, X.-F. (2021) · Current Opinion in Plant Biology · doi:10.1016/j.pbi.2021.102030 · Cited by 915
Regulation of the NADPH Oxidase RBOHD During Plant Immunity
Kadota, Y., Shirasu, K., & Zipfel, C. (2015) · Plant and Cell Physiology · doi:10.1093/pcp/pcv063 · Cited by 641
ROS, Calcium, and Electric Signals: Key Mediators of Rapid Systemic Signaling in Plants
Gilroy, S., Białasek, M., Suzuki, N., Górecka, M., Devireddy, A. R., Karpiński, S., & Mittler, R. (2016) · Plant Physiology · doi:10.1104/pp.16.00434 · Cited by 632
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Jones, J. D. G., Staskawicz, B. J., & Dangl, J. L. (2024) · Cell · doi:10.1016/j.cell.2024.03.045 · Cited by 544
Metadata
- Authors
- Li, L., Li, M., Yu, L., Zhou, Z., Liang, X., Liu, Z., Cai, G., Gao, L., Zhang, X., Wang, Y., Chen, S., & Zhou, J.-M.
- Venue
- Cell Host & Microbe
- Publisher
- Elsevier BV
- Published
- 2014-03
- Volume
- 15
- Issue
- 3
- Pages
- 329-338
- ISSN
- 1931-3128 (ISSN-L)
- OpenAlex
- W2031939620
- Cited by
- 845
- References
- 0
- FWCI
- 62.71
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: The FLS2-Associated Kinase BIK1 Directly Phosphorylates the NADPH Oxidase RbohD to Control Plant Immunity. https://app.cochat.ai/papers/10.1016/j.chom.2014.02.009
- The paper
- Li, L., Li, M., Yu, L., Zhou, Z., Liang, X., Liu, Z., Cai, G., Gao, L., Zhang, X., Wang, Y., Chen, S., & Zhou, J.-M. (2014). The FLS2-Associated Kinase BIK1 Directly Phosphorylates the NADPH Oxidase RbohD to Control Plant Immunity. Cell Host & Microbe. https://doi.org/10.1016/j.chom.2014.02.009
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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