The DOI matches its Crossref record; 93 of the 93 references it cites were found in a registry or an index.
Regulation of the NADPH Oxidase RBOHD During Plant Immunity
Open accessAbstract
Pathogen recognition induces the production of reactive oxygen species (ROS) by NADPH oxidases in both plants and animals. ROS have direct antimicrobial properties, but also serve as signaling molecules to activate further immune outputs. However, ROS production has to be tightly controlled to avoid detrimental effects on host cells, but yet must be produced in the right amount, at the right place and at the right time upon pathogen perception. Plant NADPH oxidases belong to the respiratory burst oxidase homolog (RBOH) family, which contains 10 members in the model plant Arabidopsis thaliana. The perception of pathogen-associated molecular patterns (PAMPs) by pattern recognition receptors (PRRs) leads to a rapid, specific and strong production of ROS, which is dependent on RBOHD. RBOHD is mainly controlled by Ca(2+) via direct binding to EF-hand motifs and phosphorylation by Ca(2+)-dependent protein kinases. Recent studies have, however, revealed a critical role for a Ca(2+)-independent regulation of RBOHD. The plasma membrane-associated cytoplasmic kinase BIK1 (BOTRYTIS-INDUCED KINASE1), which is a direct substrate of the PRR complex, directly interacts with and phosphorylates RBOHD upon PAMP perception. Impairment of these phosphorylation events completely abolishes the function of RBOHD in immunity. These results suggest that RBOHD activity is tightly controlled by multilayered regulations. In this review, we summarize recent advances in our understanding of the regulatory mechanisms controlling RBOHD activation.
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Cites
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Cited by
Induced Systemic Resistance for Improving Plant Immunity by Beneficial Microbes
Yu, Y., Gui, Y., Li, Z., Jiang, C., Guo, J., & Niu, D. (2022) · Plants · doi:10.3390/plants11030386 · Cited by 570
Oxidative Stress and Antioxidant Metabolism under Adverse Environmental Conditions: a Review
García-Caparrós, P., De Filippis, L., Gul, A., Hasanuzzaman, M., Ozturk, M., Altay, V., & Lao, M. T. (2021) · The Botanical Review · doi:10.1007/s12229-020-09231-1 · Cited by 555
Calcium transport across plant membranes: mechanisms and functions
Demidchik, V., Shabala, S., Isayenkov, S., Cuin, T. A., & Pottosin, I. (2018) · New Phytologist · doi:10.1111/nph.15266 · Cited by 459
Orchestrating rapid long‐distance signaling in plants with Ca2+, ROS and electrical signals
Choi, W., Miller, G., Wallace, I., Harper, J., Mittler, R., & Gilroy, S. (2017) · The Plant Journal · doi:10.1111/tpj.13492 · Cited by 312
Sadhu, A., Moriyasu, Y., Acharya, K., & Bandyopadhyay, M. (2019) · Scientific Reports · doi:10.1038/s41598-019-45470-y · Cited by 48
Metadata
- Authors
- Kadota, Y., Shirasu, K., & Zipfel, C.
- Venue
- Plant and Cell Physiology
- Publisher
- Oxford University Press (OUP)
- Published
- 2015-05-04
- Volume
- 56
- Issue
- 8
- Pages
- 1472-1480
- ISSN
- 0032-0781 (ISSN-L)
- 1471-9053
- OpenAlex
- W2211341584
- Cited by
- 641
- References
- 93
- FWCI
- 48.53
- Type
- journal article
- Language
- en
- Open access
- bronze
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