The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.
Convergent Targeting of a Common Host Protein-Network by Pathogen Effectors from Three Kingdoms of Life
Open accessAbstract
SUMMARY While conceptual principles governing plant immunity are becoming clear, its systems-level organization and the evolutionary dynamic of the host-pathogen interface are still obscure. We generated a systematic protein-protein interaction network of virulence effectors from the ascomycete pathogen Golovinomyces orontii and Arabidopsis thaliana host proteins. We combined this dataset with corresponding data for the eubacterial pathogen Pseudomonas syringae and the oomycete pathogen Hyaloperonospora arabidopsidis. The resulting network identifies host proteins onto which intraspecies and interspecies pathogen effectors converge. Phenotyping of 124 Arabidopsis effector-interactor mutants revealed a correlation between intra- and interspecies convergence and several altered immune response phenotypes. The effectors and most heavily targeted host protein co-localized in sub-nuclear foci. Products of adaptively selected Arabidopsis genes are enriched for interactions with effector targets. Our data suggest the existence of a molecular host-pathogen interface that is conserved across Arabidopsis accessions, while evolutionary adaptation occurs in the immediate network neighborhood of effector targets.
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Metadata
- Authors
- Weßling, R., Epple, P., Altmann, S., He, Y., Yang, L., Henz, S. R., McDonald, N., Wiley, K., Bader, K. C., Gläßer, C., Mukhtar, M. S., Haigis, S., Ghamsari, L., Stephens, A. E., Ecker, J. R., Vidal, M., Jones, J. D. G., Mayer, K. F. X., Ver Loren van Themaat, E., Weigel, D., Schulze-Lefert, P., Dangl, J. L., Panstruga, R., & Braun, P.
- Venue
- Cell Host & Microbe
- Publisher
- Elsevier BV
- Published
- 2014-09
- Volume
- 16
- Issue
- 3
- Pages
- 364-375
- ISSN
- 1931-3128 (ISSN-L)
- OpenAlex
- W2162665092
- Cited by
- 406
- References
- 42
- FWCI
- 34.60
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Weßling, R., Epple, P., Altmann, S., He, Y., Yang, L., Henz, S. R., McDonald, N., Wiley, K., Bader, K. C., Gläßer, C., Mukhtar, M. S., Haigis, S., Ghamsari, L., Stephens, A. E., Ecker, J. R., Vidal, M., Jones, J. D. G., Mayer, K. F. X., Ver Loren van Themaat, E., . . . Braun, P. (2014). Convergent Targeting of a Common Host Protein-Network by Pathogen Effectors from Three Kingdoms of Life. Cell Host & Microbe. https://doi.org/10.1016/j.chom.2014.08.004
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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