The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
The Oxidative Stress Network of Mycobacterium tuberculosis Reveals Coordination between Radical Detoxification Systems
Open accessAbstract
SUMMARY M. tuberculosis (Mtb) survives a hostile environment within the host that is shaped in part by oxidative stress. The mechanisms used by Mtb to resist these stresses remain ill-defined because the complex combination of oxidants generated by host immunity is difficult to accurately recapitulate in vitro. We performed a genome-wide genetic interaction screen to comprehensively delineate oxidative stress resistance pathways necessary for Mtb to resist oxidation during infection. Our analysis predicted functional relationships between the superoxide-detoxifying enzyme (SodA), an integral membrane protein (DoxX), and a predicted thiol-oxidoreductase (SseA). Consistent with that, SodA, DoxX and SseA form a membrane-associated oxidoreductase complex (MRC) that physically links radical detoxification with cytosolic thiol homeostasis. Loss of any MRC component correlated with defective recycling of mycothiol and accumulation of cellular oxidative damage. This previously uncharacterized coordination between oxygen radical detoxification and thiol homeostasis is required to overcome the oxidative environment Mtb encounters in the host.
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The Genetic Landscape of a Cell
Costanzo, M., Baryshnikova, A., Bellay, J., Kim, Y., Spear, E. D., Sevier, C. S., Ding, H., Koh, J. L. Y., Toufighi, K., Mostafavi, S., et al. (2010) · Science · doi:10.1126/science.1180823 · Cited by 2,162
Toxicity of iron and hydrogen peroxide: the Fenton reaction
Winterbourn, C. C. (1995) · Toxicology Letters · doi:10.1016/0378-4274(95)03532-x · Cited by 1,415
Griffin, J. E., Gawronski, J. D., DeJesus, M. A., Ioerger, T. R., Akerley, B. J., & Sassetti, C. M. (2011) · PLoS Pathogens · doi:10.1371/journal.ppat.1002251 · Cited by 1,048
Self-citationSulphane sulphur in biological systems: a possible regulatory role
Toohey, J. I. (1989) · Biochemical Journal · doi:10.1042/bj2640625 · Cited by 246
Sampson, S. L., Dascher, C. C., Sambandamurthy, V. K., Russell, R. G., Jacobs, W. R., Bloom, B. R., & Hondalus, M. K. (2004) · Infection and Immunity · doi:10.1128/iai.72.5.3031-3037.2004 · Cited by 153
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Cited by
DeJesus, M. A., Gerrick, E. R., Xu, W., Park, S. W., Long, J. E., Boutte, C. C., Rubin, E. J., Schnappinger, D., Ehrt, S., Fortune, S. M., et al. (2017) · mBio · doi:10.1128/mbio.02133-16 · Cited by 668
Self-citationNitric oxide prevents a pathogen-permissive granulocytic inflammation during tuberculosis
Mishra, B. B., Lovewell, R. R., Olive, A. J., Zhang, G., Wang, W., Eugenin, E., Smith, C. M., Phuah, J. Y., Long, J. E., Dubuke, M. L., et al. (2017) · Nature Microbiology · doi:10.1038/nmicrobiol.2017.72 · Cited by 284
Self-citationXu, W., DeJesus, M. A., Rücker, N., Engelhart, C. A., Wright, M. G., Healy, C., Lin, K., Wang, R., Park, S. W., Ioerger, T. R., et al. (2017) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01334-17 · Cited by 115
Laothamteep, N., Kawano, H., Vejarano, F., Suzuki-Minakuchi, C., Shintani, M., Nojiri, H., & Pinyakong, O. (2021) · Environmental Pollution · doi:10.1016/j.envpol.2021.116769 · Cited by 80
Chemistry and Redox Biology of Mycothiol
Reyes, A. M., Pedre, B., De Armas, M. I., Tossounian, M.-A., Radi, R., Messens, J., & Trujillo, M. (2018) · Antioxidants & Redox Signaling · doi:10.1089/ars.2017.7074 · Cited by 64
Metadata
- Authors
- Nambi, S., Long, J. E., Mishra, B. B., Baker, R., Murphy, K. C., Olive, A. J., Nguyen, H. P., Shaffer, S. A., & Sassetti, C. M.
- Venue
- Cell Host & Microbe
- Publisher
- Elsevier BV
- Published
- 2015-06
- Volume
- 17
- Issue
- 6
- Pages
- 829-837
- ISSN
- 1931-3128 (ISSN-L)
- OpenAlex
- W1539125891
- Cited by
- 181
- References
- 6
- FWCI
- 10.84
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Nambi, S., Long, J. E., Mishra, B. B., Baker, R., Murphy, K. C., Olive, A. J., Nguyen, H. P., Shaffer, S. A., & Sassetti, C. M. (2015). The Oxidative Stress Network of Mycobacterium tuberculosis Reveals Coordination between Radical Detoxification Systems. Cell Host & Microbe. https://doi.org/10.1016/j.chom.2015.05.008
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
