Student or educator? Sign up with your school email and get 6 months of Pro free.
CoChat
Sign Up
Cited by 284

The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.

Nitric oxide prevents a pathogen-permissive granulocytic inflammation during tuberculosis

Open access
Mishra, Bibhuti B., Lovewell, Rustin R., Olive, Andrew J., Zhang, Guoliang, Wang, Wenfei, Eugenin, Eliseo, Smith, Clare M., Phuah, Jia Yao, Long, Jarukit E., Dubuke, Michelle L., Palace, Samantha G., Goguen, Jon D., Baker, Richard E., Nambi, Subhalaxmi, Mishra, Rabinarayan, Booty, Matthew G., Baer, Christina E., Shaffer, Scott A., Dartois, Veronique, McCormick, Beth A., Chen, Xinchun, Sassetti, Christopher M.·2017·Nature Microbiology
DOI 10.1038/nmicrobiol.2017.72
Open this paper in CoChat — free account

Abstract

Nitric oxide contributes to protection from tuberculosis. It is generally assumed that this protection is due to direct inhibition of Mycobacterium tuberculosis growth, which prevents subsequent pathological inflammation. In contrast, we report that nitric oxide primarily protects mice by repressing an interleukin-1- and 12/15-lipoxygenase-dependent neutrophil recruitment cascade that promotes bacterial replication. Using M. tuberculosis mutants as indicators of the pathogen's environment, we inferred that granulocytic inflammation generates a nutrient-replete niche that supports M. tuberculosis growth. Parallel clinical studies indicate that a similar inflammatory pathway promotes tuberculosis in patients. The human 12/15-lipoxygenase orthologue, ALOX12, is expressed in cavitary tuberculosis lesions; the abundance of its products correlates with the number of airway neutrophils and bacterial burden and a genetic polymorphism that increases ALOX12 expression is associated with tuberculosis risk. These data suggest that M. tuberculosis exploits neutrophilic inflammation to preferentially replicate at sites of tissue damage that promote contagion.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1038/nmicrobiol.2017.72

Cites

48 of 48 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Show all 48 references

Cited by

See all 284

Metadata

Authors
Mishra, B. B., Lovewell, R. R., Olive, A. J., Zhang, G., Wang, W., Eugenin, E., Smith, C. M., Phuah, J. Y., Long, J. E., Dubuke, M. L., Palace, S. G., Goguen, J. D., Baker, R. E., Nambi, S., Mishra, R., Booty, M. G., Baer, C. E., Shaffer, S. A., Dartois, V., McCormick, B. A., Chen, X., & Sassetti, C. M.
Venue
Nature Microbiology
Publisher
Springer Science and Business Media LLC
Published
2017-05-15
Volume
2
Issue
7
Pages
17072-17072
ISSN
2058-5276 (ISSN-L)
DOI
10.1038/nmicrobiol.2017.72
OpenAlex
W2614705174
Cited by
284
References
48
FWCI
20.26
Type
journal article
Language
en
Open access
green

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

How to cite

Cite CoChat for the checks on this page, and the paper for its own findings.

This page
CoChat. (2026). Citation check: Nitric oxide prevents a pathogen-permissive granulocytic inflammation during tuberculosis. https://app.cochat.ai/papers/10.1038/nmicrobiol.2017.72
The paper
Mishra, B. B., Lovewell, R. R., Olive, A. J., Zhang, G., Wang, W., Eugenin, E., Smith, C. M., Phuah, J. Y., Long, J. E., Dubuke, M. L., Palace, S. G., Goguen, J. D., Baker, R. E., Nambi, S., Mishra, R., Booty, M. G., Baer, C. E., Shaffer, S. A., Dartois, V., . . . Sassetti, C. M. (2017). Nitric oxide prevents a pathogen-permissive granulocytic inflammation during tuberculosis. Nature Microbiology. https://doi.org/10.1038/nmicrobiol.2017.72

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.