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Both Neutralizing and Non-Neutralizing Human H7N9 Influenza Vaccine-Induced Monoclonal Antibodies Confer Protection
Open accessAbstract
Pathogenic H7N9 avian influenza viruses continue to represent a public health concern, and several candidate vaccines are currently being developed. It is vital to assess if protective antibodies are induced following vaccination and to characterize the diversity of epitopes targeted. Here we characterized the binding and functional properties of twelve H7-reactive human antibodies induced by a candidate A/Anhui/1/2013 (H7N9) vaccine. Both neutralizing and non-neutralizing antibodies protected mice in vivo during passive transfer challenge experiments. Mapping the H7 hemagglutinin antigenic sites by generating escape mutant variants against the neutralizing antibodies identified unique epitopes on the head and stalk domains. Further, the broadly cross-reactive non-neutralizing antibodies generated in this study were protective through Fc-mediated effector cell recruitment. These findings reveal important properties of vaccine-induced antibodies and provide a better understanding of the human monoclonal antibody response to influenza in the context of vaccines.
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“indeed partial or non-neutralizing antibodies may confer protection (Henry Dunand et al., 2016).”
From Reduced neutralization of SARS-CoV-2 B.1.1.7 variant by convalescent and vaccine sera (2021) · cites this paper as Henry Dunand et al., 2016
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Self-citationHighly Conserved Protective Epitopes on Influenza B Viruses
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Self-citationDiLillo, D. J., Tan, G. S., Palese, P., & Ravetch, J. V. (2014) · Nature Medicine · doi:10.1038/nm.3443 · Cited by 749
Self-citationSafety and Immunogenicity of an Inactivated Subvirion Influenza A (H5N1) Vaccine
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Self-citationChen, H., Yuan, H., Gao, R., Zhang, J., Wang, D., Xiong, Y., Fan, G., Yang, F., Li, X., Zhou, J., et al. (2014) · The Lancet · doi:10.1016/s0140-6736(14)60111-2 · Cited by 648
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Self-citationAntibiotics-Driven Gut Microbiome Perturbation Alters Immunity to Vaccines in Humans
Hagan, T., Cortese, M., Rouphael, N., Boudreau, C., Linde, C., Maddur, M. S., Das, J., Wang, H., Guthmiller, J., Zheng, N.-Y., et al. (2019) · Cell · doi:10.1016/j.cell.2019.08.010 · Cited by 572
Self-citationNatural polyreactive IgA antibodies coat the intestinal microbiota
Bunker, J. J., Erickson, S. A., Flynn, T. M., Henry, C., Koval, J., Meisel, M., Jabrì, B., Antonopoulos, D. A., Wilson, P. C., & Bendelac, A. S. (2017) · Science · doi:10.1126/science.aan6619 · Cited by 470
Self-citationReduced neutralization of SARS-CoV-2 B.1.1.7 variant by convalescent and vaccine sera
Supasa, P., Zhou, D., Dejnirattisai, W., Liu, C., Mentzer, A. J., Ginn, H. M., Zhao, Y., Duyvesteyn, H. M. E., Nutalai, R., Tuekprakhon, A., et al. (2021) · Cell · doi:10.1016/j.cell.2021.02.033 · Cited by 460
Chen, Y.-Q., Wohlbold, T. J., Zheng, N., Huang, M., Huang, Y., Neu, K. E., Lee, J., Wan, H., Rojas, K. T., Roubidoux, E. K., et al. (2018) · Cell · doi:10.1016/j.cell.2018.03.030 · Cited by 419
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Metadata
- Authors
- Henry Dunand, C. J., Leon, P. E., Huang, M., Choi, A., Chromikova, V., Ho, I. Y., Tan, G. S., Cruz, J., Hirsh, A., Zheng, N.-Y., Mullarkey, C. E., Ennis, F. A., Terajima, M., Treanor, J. J., Topham, D. J., Subbarao, K., Palese, P., Krammer, F., & Wilson, P. C.
- Affiliations
- Icahn School of Medicine at Mount Sinai (US)
- University of Chicago (US)
- University of Massachusetts Chan Medical School (US)
- University of Rochester Medicine (US)
- National Institutes of Health (US)
- Corresponding author
- Krammer, Florian
- Wilson, Patrick C.
- ORCID
- Venue
- Cell Host & Microbe
- Publisher
- Elsevier BV
- Published
- 2016-06
- Volume
- 19
- Issue
- 6
- Pages
- 800-813
- ISSN
- 1931-3128 (ISSN-L)
- PMC
- PMC4901526
- OpenAlex
- W2417981936
- Cited by
- 268
- References
- 53
- Citations by year
- 2026: 10 · 2025: 12 · 2024: 18 · 2023: 19 · 2022: 23 · 2021: 32 · 2020: 32 · 2019: 30 · 2018: 37 · 2017: 42 · 2016: 13
- FWCI
- 38.38
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell Host & Microbe (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- World Health Organization
- National Institute of Allergy and Infectious Diseases (HHSN272201400008C), U19AI109946, P01AI097092, HHSN272200900026C, HHSN272201400005C, U19AI082724, U19AI057266, HHSN 272201400006C)
- Topics
- Health Sciences › Medicine › Epidemiology › Influenza Virus Research Studies
- Life Sciences › Immunology and Microbiology › Immunology › Monoclonal and Polyclonal Antibodies Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › vaccines and immunoinformatics approaches
- Keywords
- H7N9 avian influenza, influenza vaccination, monoclonal antibodies, neutralizing antibodies, non-neutralizing antibodies, hemagglutinin epitope, hemagglutinin stalk domain, cross-reactive antibodies, vaccine-induced antibody response
- MeSH terms
- Animals, Antibodies, Monoclonal, Antibodies, Viral, Antigens, Viral, Disease Models, Animal, Dogs, Female, Humans, Influenza, Human, Influenza Vaccines, Mice, Inbred BALB C, Orthomyxoviridae Infections, Hemagglutinin Glycoproteins, Influenza Virus, Mice, Antibodies, Neutralizing, HEK293 Cells, Madin Darby Canine Kidney Cells, Influenza A Virus, H7N9 Subtype
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