Antibody Recognition of a Highly Conserved Influenza Virus Epitope

Structure of an HIV gp120 envelope glycoprotein in complex with the CD4 receptor and a neutralizing human antibody

Kwong, P. D., Wyatt, R. T., Robinson, J. E., Sweet, R. W., Sodroski, J., & Hendrickson, W. A. (1998) · Nature · doi:10.1038/31405 · Cited by 2,963 · see citing works

Structure of the haemagglutinin membrane glycoprotein of influenza virus at 3 Å resolution

Wilson, I. A., Skehel, J. J., & Wiley, D. C. (1981) · Nature · doi:10.1038/289366a0 · Cited by 2,535 · see citing works

Structural identification of the antibody-binding sites of Hong Kong influenza haemagglutinin and their involvement in antigenic variation

Wiley, D. C., Wilson, I. A., & Skehel, J. J. (1981) · Nature · doi:10.1038/289373a0 · Cited by 1,623 · see citing works

Structure of influenza haemagglutinin at the pH of membrane fusion

Bullough, P. A., Hughson, F. M., Skehel, J. J., & Wiley, D. C. (1994) · Nature · doi:10.1038/371037a0 · Cited by 1,564 · see citing works

An αβ T Cell Receptor Structure at 2.5 Å and Its Orientation in the TCR-MHC Complex

García, K. C., Degano, M., Stanfield, R. L., Brunmark, A. B., Jackson, M. R., Peterson, P. A., Teyton, L., & Wilson, I. A. (1996) · Science · doi:10.1126/science.274.5285.209 · Cited by 1,301 · see citing works

Structure and Receptor Specificity of the Hemagglutinin from an H5N1 Influenza Virus

Stevens, J., Blixt, O., Tumpey, T. M., Taubenberger, J. K., Paulson, J. C., & Wilson, I. A. (2006) · Science · doi:10.1126/science.1124513 · Cited by 941 · see citing works

Avian-to-human transmission of the PB1 gene of influenza A viruses in the 1957 and 1968 pandemics

Kawaoka, Y., Krauss, S. L., & Webster, R. G. (1989) · Journal of Virology · doi:10.1128/jvi.63.11.4603-4608.1989 · Cited by 809 · see citing works

Resistant influenza A viruses in children treated with oseltamivir: descriptive study

Kiso, M., Mitamura, K., Sakai‐Tagawa, Y., Shiraishi, K., Kawakami, C., Kimura, K., Hayden, F. G., Sugaya, N., & Kawaoka, Y. (2004) · The Lancet · doi:10.1016/s0140-6736(04)16934-1 · Cited by 785 · see citing works

Structural definition of a conserved neutralization epitope on HIV-1 gp120

Zhou, T., Xu, L., Dey, B., Hessell, A. J., Van Ryk, D., Xiang, S.-H., Yang, X., Zhang, M.-Y., Zwick, M. B., Arthos, J., et al. (2007) · Nature · doi:10.1038/nature05580 · Cited by 770 · see citing works

Heterosubtypic Neutralizing Monoclonal Antibodies Cross-Protective against H5N1 and H1N1 Recovered from Human IgM+ Memory B Cells

Throsby, M., van den Brink, E. N., Jongeneelen, M. A. C., Poon, L. L. M., Alard, P., Cornelissen, L. A. H. M., Bakker, A. Q., Cox, F., van Deventer, E., Guan, Y., et al. (2008) · PLoS ONE · doi:10.1371/journal.pone.0003942 · Cited by 738 · see citing works

Changes in the conformation of influenza virus hemagglutinin at the pH optimum of virus-mediated membrane fusion

Skehel, J. J., Bayley, P. M., Brown, E. B., Martin, S. R., Waterfield, M. D., White, J. M., Wilson, I. A., & Wiley, D. C. (1982) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.79.4.968 · Cited by 726 · see citing works

The Structure and Receptor Binding Properties of the 1918 Influenza Hemagglutinin

Gamblin, S. J., Haire, L. F., Russell, R. J., Stevens, D. J., Xiao, B., Ha, Y., Vasisht, N., Steinhauer, D. A., Daniels, R. S., Elliot, A. J., et al. (2004) · Science · doi:10.1126/science.1093155 · Cited by 712 · see citing works

Adamantane Resistance Among Influenza A Viruses Isolated Early During the 2005-2006 Influenza Season in the United States

Bright, R. A. (2006) · JAMA · doi:10.1001/jama.295.8.joc60020 · Cited by 671 · see citing works

Haemagglutinin mutations responsible for the binding of H5N1 influenza A viruses to human-type receptors

Yamada, S., Suzuki, Y., Suzuki, T., Le, M. Q., Nidom, C. A., Sakai‐Tagawa, Y., Muramoto, Y., Ito, M., Kiso, M., Horimoto, T., et al. (2006) · Nature · doi:10.1038/nature05264 · Cited by 639 · see citing works

Origin and evolution of the 1918 “Spanish” influenza virus hemagglutinin gene

Reid, A. H., Fanning, T. G., Hultin, J. V., & Taubenberger, J. K. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.4.1651 · Cited by 607 · see citing works

A common neutralizing epitope conserved between the hemagglutinins of influenza A virus H1 and H2 strains

Okuno, Y., Isegawa, Y., Sasao, F., & Ueda, S. (1993) · Journal of Virology · doi:10.1128/jvi.67.5.2552-2558.1993 · Cited by 489 · see citing works

Antigenic structure of influenza virus haemagglutinin defined by hybridoma antibodies

Gerhard, W., Yewdell, J. W., Frankel, M. E., & Webster, R. G. (1981) · Nature · doi:10.1038/290713a0 · Cited by 460 · see citing works

Structural repertoire of the human VH segments

Chothia, C., Lesk, A. M., Gherardi, E., Tomlinson, I. M., Walter, G., Marks, J. D., Llewelyn, M. B., & Winter, G. P. (1992) · Journal of Molecular Biology · doi:10.1016/0022-2836(92)90224-8 · Cited by 393 · see citing works

Toward an AIDS Vaccine

Walker, B. D., & Burton, D. R. (2008) · Science · doi:10.1126/science.1152622 · Cited by 338 · see citing works

Structure of influenza hemagglutinin in complex with an inhibitor of membrane fusion

Russell, R. J. M., Kerry, P. S., Stevens, D. J., Steinhauer, D. A., Martin, S. R., Gamblin, S. J., & Skehel, J. J. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0807142105 · Cited by 314 · see citing works

Antibody vs. HIV in a clash of evolutionary titans

Burton, D. R., Stanfield, R. L., & Wilson, I. A. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0505126102 · Cited by 300 · see citing works

N- and C-terminal residues combine in the fusion-pH influenza hemagglutinin HA 2 subunit to form an N cap that terminates the triple-stranded coiled coil

Chen, J., Skehel, J. J., & Wiley, D. C. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.16.8967 · Cited by 295 · see citing works

Structural basis of tyrosine sulfation and V H -gene usage in antibodies that recognize the HIV type 1 coreceptor-binding site on gp120

Huang, C.-C., Venturi, M., Majeed, S., Moore, M. J., Phogat, S. K., Zhang, M.-Y., Dimitrov, D. S., Hendrickson, W. A., Robinson, J. E., Sodroski, J., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308527100 · Cited by 275 · see citing works

Combinatorial antibody libraries from survivors of the Turkish H5N1 avian influenza outbreak reveal virus neutralization strategies

Kashyap, A. K., Steel, J., Öner, A. F., Dillon, M. A., Swale, R. E., Wall, K. M., Perry, K. J., Faynboym, A. M., Ilhan, M. M., Horowitz, M., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0801367105 · Cited by 252 · see citing works

Origin of the Pandemic 1957 H2 Influenza A Virus and the Persistence of Its Possible Progenitors in the Avian Reservoir

Schäffr, J. R., Kawaoka, Y., Bean, W. J., Süß, J., Senne, D. A., & Webster, R. G. (1993) · Virology · doi:10.1006/viro.1993.1319 · Cited by 245 · see citing works

Current and future antiviral therapy of severe seasonal and avian influenza

Beigel, J. H., & Bray, M. (2008) · Antiviral Research · doi:10.1016/j.antiviral.2008.01.003 · Cited by 233 · see citing works

Evolution of the H3 influenza virus hemagglutinin from human and nonhuman hosts

Bean, W. J., Schell, M. J., Katz, J. M., Kawaoka, Y., Naeve, C. W., Gorman, O. T., & Webster, R. G. (1992) · Journal of Virology · doi:10.1128/jvi.66.2.1129-1138.1992 · Cited by 231 · see citing works

A complex of influenza hemagglutinin with a neutralizing antibody that binds outside the virus receptor binding site.

Fleury, D., Barrere, B., Bizebard, T., Daniels, R. S., Skehel, J. J., & Knossow, M. (1999) · Nature Structural Biology · doi:10.1038/9299 · Cited by 154 · see citing works

An Antibody That Prevents the Hemagglutinin Low pH Fusogenic Transition

Barbey-Martin, C., Gigant, B., Bizebard, T., Calder, L. J., Wharton, S. A., Skehel, J. J., & Knossow, M. (2002) · Virology · doi:10.1006/viro.2001.1320 · Cited by 142 · see citing works

Structural basis for HIV-1 neutralization by a gp41 fusion intermediate–directed antibody

Luftig, M. A., Mattu, M., Giovine, P. D., Geleziunas, R., Hrin, R. C., Barbato, G., Bianchi, E., Miller, M. D., Pessi, A., & Carfı́, A. (2006) · Nature Structural & Molecular Biology · doi:10.1038/nsmb1127 · Cited by 129 · see citing works

Antigen distortion allows influenza virus to escape neutralization

Fleury, D., Wharton, S. A., Skehel, J. J., Knossow, M., & Bizebard, T. (1998) · Nature Structural Biology · doi:10.1038/nsb0298-119 · Cited by 124 · see citing works

Similarity-driven flexible ligand docking

Fradera, X., Knegtel, R. M. A., & Mestres, J. (2000) · Proteins Structure Function and Bioinformatics · doi:10.1002/1097-0134(20000901)40:4 · Cited by 89 · see citing works

Manufacturing Immunity to Disease in a Test Tube: The Magic Bullet Realized

Lerner, R. A. (2006) · Angewandte Chemie International Edition · doi:10.1002/anie.200603381 · Cited by 73 · see citing works

The evolutionary and structural ‘logic’ of antigen receptor diversity

Davis, M. M. (2004) · Seminars in Immunology · doi:10.1016/j.smim.2004.08.003 · Cited by 69 · see citing works

HIV-1 Neutralization: Mechanisms and Relevance to Vaccine Design

Zwick, M. B., & Burton, D. R. (2007) · Current HIV Research · doi:10.2174/157016207782418443 · Cited by 58 · see citing works

Influenza Virus Transmission: Basic Science and Implications for the Use of Antiviral Drugs During a Pandemic

Lowen, A. C., & Palese, P. (2007) · Infectious Disorders - Drug Targets · doi:10.2174/187152607783018736 · Cited by 57 · see citing works

Interim Within-Season Estimate of the Effectiveness of Trivalent Inactivated Influenza Vaccine—Marshfield, Wisconsin, 2007-08 Influenza Season

(2008) · JAMA · doi:10.1001/jama.299.20.2381 · Cited by 53 · see citing works

An epitope shared by the hemagglutinins of H1, H2, H5, and H6 subtypes of influenza A virus.

Smirnov, Y. A., Lipatov, A. S., Калмановна, Г. А., Okuno, Y., van Beek, R., Osterhaus, A. D. M. E., & Claas, E. C. (1999) · PubMed · Cited by 52 · see citing works

The contents of the syringe

Salzberg, S. L. (2008) · Nature · doi:10.1038/454160a · Cited by 40 · see citing works

Potent Neutralizing Antibodies against SARS-CoV-2 Identified by High-Throughput Single-Cell Sequencing of Convalescent Patients’ B Cells

Cao, Y., Su, B., Guo, X., Sun, W., Deng, Y., Bao, L., Zhu, Q., Zhang, X., Zheng, Y., Geng, C., et al. (2020) · Cell · doi:10.1016/j.cell.2020.05.025 · Cited by 1,188 · see citing works

FUBAR: A Fast, Unconstrained Bayesian AppRoximation for Inferring Selection

Murrell, B., Moola, S., Mabona, A., Weighill, T., Sheward, D. J., Pond, S. L. K., & Scheffler, K. (2013) · Molecular Biology and Evolution · doi:10.1093/molbev/mst030 · Cited by 1,368 · see citing works

A Neutralizing Antibody Selected from Plasma Cells That Binds to Group 1 and Group 2 Influenza A Hemagglutinins

Corti, D., Voss, J., Gamblin, S. J., Codoni, G., Macagno, A., Jarrossay, D., Vachieri, S. G., Pinna, D., Minola, A., Vanzetta, F., et al. (2011) · Science · doi:10.1126/science.1205669 · Cited by 1,203 · see citing works

Immunogenicity and structures of a rationally designed prefusion MERS-CoV spike antigen

Pallesen, J., Wang, N., Corbett, K. S., Wrapp, D., Kirchdoerfer, R. N., Turner, H. L., Cottrell, C. A., Becker, M. M., Wang, L., Shi, W., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1707304114 · Cited by 1,073 · see citing works

Self-assembling influenza nanoparticle vaccines elicit broadly neutralizing H1N1 antibodies

Kanekiyo, M., Wei, C., Yassine, H. M., McTamney, P. M., Boyington, J. C., Whittle, J. R. R., Rao, S. S., Kong, W., Wang, L., & Nabel, G. J. (2013) · Nature · doi:10.1038/nature12202 · Cited by 887 · see citing works

Structure of RSV Fusion Glycoprotein Trimer Bound to a Prefusion-Specific Neutralizing Antibody

McLellan, J. S., Chen, M., Leung, S., Graepel, K. W., Du, X., Yang, Y., Zhou, T., Baxa, U., Yasuda, E., Beaumont, T., et al. (2013) · Science · doi:10.1126/science.1234914 · Cited by 883 · see citing works

Highly Conserved Protective Epitopes on Influenza B Viruses

Dreyfus, C., Laursen, N. S., Kwaks, T., Zuijdgeest, D., Khayat, R., Ekiert, D. C., Lee, J. H., Metlagel, Z., Bujny, M. V., Jongeneelen, M. A. C., et al. (2012) · Science · doi:10.1126/science.1222908 · Cited by 867 · see citing works

A Highly Conserved Neutralizing Epitope on Group 2 Influenza A Viruses

Ekiert, D. C., Friesen, R. H. E., Bhabha, G., Kwaks, T., Jongeneelen, M. A. C., Yu, W., Ophorst, C., Cox, F., Korse, H. J. W. M., Brandenburg, B., et al. (2011) · Science · doi:10.1126/science.1204839 · Cited by 823 · see citing works

The human antibody response to influenza A virus infection and vaccination

Krammer, F. (2019) · Nature reviews. Immunology · doi:10.1038/s41577-019-0143-6 · Cited by 805 · see citing works

Broadly cross-reactive antibodies dominate the human B cell response against 2009 pandemic H1N1 influenza virus infection

Wrammert, J., Koutsonanos, D., Li, G., Edupuganti, S., Sui, J., Michael, M., McCausland, M. M., Skountzou, I., Hornig, M., Lipkin, W. I., et al. (2011) · The Journal of Experimental Medicine · doi:10.1084/jem.20101352 · Cited by 777 · see citing works

Rational HIV Immunogen Design to Target Specific Germline B Cell Receptors

Jardine, J., Julien, J.-P., Menis, S., Ota, T., Kalyuzhniy, O., McGuire, A., Sok, D., Huang, P.-S., MacPherson, S., Jones, M., et al. (2013) · Science · doi:10.1126/science.1234150 · Cited by 770 · see citing works

Broadly neutralizing hemagglutinin stalk–specific antibodies require FcγR interactions for protection against influenza virus in vivo

DiLillo, D. J., Tan, G. S., Palese, P., & Ravetch, J. V. (2014) · Nature Medicine · doi:10.1038/nm.3443 · Cited by 749 · see citing works

Hemagglutinin-stem nanoparticles generate heterosubtypic influenza protection

Yassine, H. M., Boyington, J. C., McTamney, P. M., Wei, C., Kanekiyo, M., Kong, W., Gallagher, J. R., Wang, L., Zhang, Y., Joyce, M. G., et al. (2015) · Nature Medicine · doi:10.1038/nm.3927 · Cited by 702 · see citing works

Antibody Structure and Function: The Basis for Engineering Therapeutics

Chiu, M. L., Goulet, D. R., Teplyakov, A., & Gilliland, G. L. (2019) · Antibodies · doi:10.3390/antib8040055 · Cited by 646 · see citing works

Influenza Hemagglutinin and Neuraminidase Membrane Glycoproteins

Gamblin, S. J., & Skehel, J. J. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.r110.129809 · Cited by 639 · see citing works

From Vaccines to Memory and Back

Sallusto, F., Lanzavecchia, A., Araki, K., & Ahmed, R. (2010) · Immunity · doi:10.1016/j.immuni.2010.10.008 · Cited by 631 · see citing works

Peptide-Based Vaccines: Current Progress and Future Challenges

Malonis, R. J., Lai, J. R., & Vergnolle, O. (2020) · Chemical Reviews · doi:10.1021/acs.chemrev.9b00472 · Cited by 602 · see citing works

Design of protein-binding proteins from the target structure alone

Cao, L., Coventry, B., Goreshnik, I., Huang, B., Sheffler, W., Park, J. S., Jude, K. M., Marković, I., Kadam, R. U., Verschueren, K. H. G., et al. (2022) · Nature · doi:10.1038/s41586-022-04654-9 · Cited by 577 · see citing works

Computational Design of Proteins Targeting the Conserved Stem Region of Influenza Hemagglutinin

Fleishman, S. J., Whitehead, T. A., Ekiert, D. C., Dreyfus, C., Corn, J. E., Strauch, E.-M., Wilson, I. A., & Baker, D. (2011) · Science · doi:10.1126/science.1202617 · Cited by 585 · see citing works

A stable trimeric influenza hemagglutinin stem as a broadly protective immunogen

Impagliazzo, A., Milder, F. J., Kuipers, H., Wagner, M. V., Zhu, X., Hoffman, R. M. B., van Meersbergen, R., Huizingh, J., Wanningen, P., Verspuij, J. W. A., et al. (2015) · Science · doi:10.1126/science.aac7263 · Cited by 591 · see citing works

Advances in the development of influenza virus vaccines

Krammer, F., & Palese, P. (2015) · Nature Reviews Drug Discovery · doi:10.1038/nrd4529 · Cited by 592 · see citing works

Influenza Virus Vaccine Based on the Conserved Hemagglutinin Stalk Domain

Steel, J., Lowen, A. C., Wang, T. T., Yondola, M. A., Gao, Q., Haye, K., García‐Sastre, A., & Palese, P. (2010) · mBio · doi:10.1128/mbio.00018-10 · Cited by 535 · see citing works

The 2009 A (H1N1) influenza virus pandemic: A review

Girard, M. P., Tam, J. S., Assossou, O. M., & Kiény, M. P. (2010) · Vaccine · doi:10.1016/j.vaccine.2010.05.031 · Cited by 489 · see citing works

B-cell–lineage immunogen design in vaccine development with HIV-1 as a case study

Haynes, B. F., Kelsoe, G. H., Harrison, S. C., & Kepler, T. B. (2012) · Nature Biotechnology · doi:10.1038/nbt.2197 · Cited by 481 · see citing works

Cross-neutralization of influenza A viruses mediated by a single antibody loop

Ekiert, D. C., Kashyap, A. K., Steel, J., Rubrum, A. M., Bhabha, G., Khayat, R., Lee, J. H., Dillon, M. A., O’Neil, R. E., Faynboym, A. M., et al. (2012) · Nature · doi:10.1038/nature11414 · Cited by 483 · see citing works

Broadly Neutralizing Antiviral Antibodies

Corti, D., & Lanzavecchia, A. (2013) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032712-095916 · Cited by 469 · see citing works

CD80 and PD-L2 define functionally distinct memory B cell subsets that are independent of antibody isotype

Zuccarino-Catania, G., Sadanand, S., Weisel, F. J., Tomayko, M. M., Meng, H., Kleinstein, S. H., Good‐Jacobson, K. L., & Shlomchik, M. J. (2014) · Nature Immunology · doi:10.1038/ni.2914 · Cited by 444 · see citing works

A dynamic T cell–limited checkpoint regulates affinity-dependent B cell entry into the germinal center

Schwickert, T. A., Victora, G. D., Fooksman, D., Kamphorst, A. O., Mugnier, M. R., Gitlin, A. D., Dustin, M. L., & Nussenzweig, M. C. (2011) · The Journal of Experimental Medicine · doi:10.1084/jem.20102477 · Cited by 427 · see citing works

Reverse vaccinology 2.0: Human immunology instructs vaccine antigen design

Rappuoli, R., Bottomley, M. J., D’Oro, U., Finco, O., & Gregorio, E. D. (2016) · The Journal of Experimental Medicine · doi:10.1084/jem.20151960 · Cited by 438 · see citing works

Heterosubtypic neutralizing antibodies are produced by individuals immunized with a seasonal influenza vaccine

Corti, D., Suguitan, A. L., Pinna, D., Silacci, C., Fernandez-Rodriguez, B. M., Zatta, F., Santos, C. P., Luke, C. J., Torres-Velez, F. J., Temperton, N. J., et al. (2010) · Journal of Clinical Investigation · doi:10.1172/jci41902 · Cited by 433 · see citing works

Structural basis of influenza virus fusion inhibition by the antiviral drug Arbidol

Kadam, R. U., & Wilson, I. A. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1617020114 · Cited by 437 · see citing works

Structure and Function Analysis of an Antibody Recognizing All Influenza A Subtypes

Kallewaard, N. L., Corti, D., Collins, P. J., Neu, U., McAuliffe, J. M., Benjamin, E., Wachter-Rosati, L., Palmer‐Hill, F. J., Yuan, A. Q., Walker, P. A., et al. (2016) · Cell · doi:10.1016/j.cell.2016.05.073 · Cited by 410 · see citing works

Chimeric Hemagglutinin Influenza Virus Vaccine Constructs Elicit Broadly Protective Stalk-Specific Antibodies

Krammer, F., Pica, N., Hai, R., Margine, I., & Palese, P. (2013) · Journal of Virology · doi:10.1128/jvi.00641-13 · Cited by 425 · see citing works

Influenza Virus: Dealing with a Drifting and Shifting Pathogen

Kim, H., Webster, R. G., & Webby, R. J. (2018) · Viral Immunology · doi:10.1089/vim.2017.0141 · Cited by 423 · see citing works

Broadly Neutralizing Antibodies Present New Prospects to Counter Highly Antigenically Diverse Viruses

Burton, D. R., Poignard, P., Stanfield, R. L., & Wilson, I. A. (2012) · Science · doi:10.1126/science.1225416 · Cited by 416 · see citing works

Immune history profoundly affects broadly protective B cell responses to influenza

Andrews, S. F., Huang, Y., Kaur, K., Popova, L. I., Ho, I. Y., Pauli, N. T., Henry, C., Taylor, W. M., Lim, S., Huang, M., et al. (2015) · Science Translational Medicine · doi:10.1126/scitranslmed.aad0522 · Cited by 413 · see citing works

Continuing challenges in influenza

Webster, R. G., & Govorkova, E. A. (2014) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12462 · Cited by 404 · see citing works

Hepatitis C Virus E2 Envelope Glycoprotein Core Structure

Kong, L., Giang, E., Nieusma, T., Kadam, R. U., Cogburn, K. E., Hua, Y., Dai, X., Stanfield, R. L., Burton, D. R., Ward, A. B., et al. (2013) · Science · doi:10.1126/science.1243876 · Cited by 398 · see citing works

Pandemic H1N1 influenza vaccine induces a recall response in humans that favors broadly cross-reactive memory B cells

Li, G.-M., Chiu, C., Wrammert, J., McCausland, M. M., Andrews, S. F., Zheng, N., Lee, J.-H., Huang, M., Qu, X., Edupuganti, S., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1118979109 · Cited by 393 · see citing works

Vaccine-Induced Antibodies that Neutralize Group 1 and Group 2 Influenza A Viruses

Joyce, M. G., Wheatley, A. K., Thomas, P. V., Chuang, G.-Y., Soto, C., Bailer, R. T., Druz, A., Georgiev, I. S., Gillespie, R. A., Kanekiyo, M., et al. (2016) · Cell · doi:10.1016/j.cell.2016.06.043 · Cited by 333 · see citing works

Learning the language of viral evolution and escape

Hie, B., Zhong, E. D., Berger, B., & Bryson, B. (2021) · Science · doi:10.1126/science.abd7331 · Cited by 361 · see citing works

Optimization of affinity, specificity and function of designed influenza inhibitors using deep sequencing

Whitehead, T. A., Chevalier, A. A., Song, Y., Dreyfus, C., Fleishman, S. J., de Mattos, C., Myers, C., Kamisetty, H., Blair, P. J., Wilson, I. A., et al. (2012) · Nature Biotechnology · doi:10.1038/nbt.2214 · Cited by 364 · see citing works

MF59 Adjuvant Enhances Diversity and Affinity of Antibody-Mediated Immune Response to Pandemic Influenza Vaccines

Khurana, S., Verma, N., Yewdell, J. W., Hilbert, A. K., Castellino, F., Lattanzi, M., Giudice, G. D., Rappuoli, R., & Golding, H. (2011) · Science Translational Medicine · doi:10.1126/scitranslmed.3002336 · Cited by 357 · see citing works

A chimeric hemagglutinin-based universal influenza virus vaccine approach induces broad and long-lasting immunity in a randomized, placebo-controlled phase I trial

Nachbagauer, R., Feser, J., Naficy, A. B., Bernstein, D. I., Guptill, J. T., Walter, E. B., Berlanda-Scorza, F., Stadlbauer, D., Wilson, P. C., Aydillo, T., et al. (2020) · Nature Medicine · doi:10.1038/s41591-020-1118-7 · Cited by 340 · see citing works

Induction of Broadly Neutralizing H1N1 Influenza Antibodies by Vaccination

Wei, C., Boyington, J. C., McTamney, P. M., Kong, W., Pearce, M. B., Xu, L., Andersen, H., Rao, S. S., Tumpey, T. M., Yang, Z., et al. (2010) · Science · doi:10.1126/science.1192517 · Cited by 337 · see citing works

Immune responses to influenza virus infection

Kreijtz, J. H. C. M., Fouchier, R. A. M., & Rimmelzwaan, G. F. (2011) · Virus Research · doi:10.1016/j.virusres.2011.09.022 · Cited by 335 · see citing works

Recurrent Potent Human Neutralizing Antibodies to Zika Virus in Brazil and Mexico

Robbiani, D. F., Bozzacco, L., Keeffe, J. R., Khouri, R., Olsen, P. C., Gazumyan, A., Schaefer-Babajew, D. J., Ávila‐Ríos, S., Nogueira, L., Patel, R., et al. (2017) · Cell · doi:10.1016/j.cell.2017.04.024 · Cited by 335 · see citing works

Next-generation influenza vaccines: opportunities and challenges

Wei, C., Crank, M. C., Shiver, J. W., Graham, B. S., Mascola, J. R., & Nabel, G. J. (2020) · Nature Reviews Drug Discovery · doi:10.1038/s41573-019-0056-x · Cited by 324 · see citing works

Structures of influenza A proteins and insights into antiviral drug targets

Das, K., Aramini, J. M., Ma, L.-C., Krug, R. M., & Arnold, E. (2010) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1779 · Cited by 330 · see citing works

Influenza virus hemagglutinin stalk-based antibodies and vaccines

Krammer, F., & Palese, P. (2013) · Current Opinion in Virology · doi:10.1016/j.coviro.2013.07.007 · Cited by 327 · see citing works

Glycans on influenza hemagglutinin affect receptor binding and immune response

Wang, C.-C., Chen, J.-R., Tseng, Y.-C., Hsu, C.-H., Hung, Y.-F., Chen, S.-W., Chen, C.-M., Khoo, K.-H., Cheng, T.-J., Cheng, Y.-S. E., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0909696106 · Cited by 316 · see citing works

HIV-1 Vaccines Based on Antibody Identification, B Cell Ontogeny, and Epitope Structure

Kwong, P. D., & Mascola, J. R. (2018) · Immunity · doi:10.1016/j.immuni.2018.04.029 · Cited by 306 · see citing works

Mosaic nanoparticle display of diverse influenza virus hemagglutinins elicits broad B cell responses

Kanekiyo, M., Joyce, M. G., Gillespie, R. A., Gallagher, J. R., Andrews, S. F., Yassine, H. M., Wheatley, A. K., Fisher, B. E., Ambrozak, D. R., Creanga, A., et al. (2019) · Nature Immunology · doi:10.1038/s41590-018-0305-x · Cited by 290 · see citing works

Vaccination with a synthetic peptide from the influenza virus hemagglutinin provides protection against distinct viral subtypes

Wang, T. T., Tan, G. S., Hai, R., Pica, N., Ngai, L., Ekiert, D. C., Wilson, I. A., García‐Sastre, A., Moran, T. M., & Palese, P. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1013387107 · Cited by 302 · see citing works

Influenza Research Database: an integrated bioinformatics resource for influenza research and surveillance

Squires, R. B., Noronha, J. M., Hunt, V., García‐Sastre, A., Macken, C. A., Baumgarth, N., Suarez, D. L., Pickett, B. E., Zhang, Y., Larsen, C. N., et al. (2012) · Influenza and Other Respiratory Viruses · doi:10.1111/j.1750-2659.2011.00331.x · Cited by 297 · see citing works

Rapid development of broadly influenza neutralizing antibodies through redundant mutations

Pappas, L., Foglierini, M., Piccoli, L., Kallewaard, N. L., Turrini, F., Silacci, C., Fernandez-Rodriguez, B. M., Agatic, G., Giacchetto-Sasselli, I., Pellicciotta, G., et al. (2014) · Nature · doi:10.1038/nature13764 · Cited by 287 · see citing works

Toward a Universal Influenza Virus Vaccine: Prospects and Challenges

Pica, N., & Palese, P. (2013) · Annual Review of Medicine · doi:10.1146/annurev-med-120611-145115 · Cited by 285 · see citing works

Epitope-based vaccine design yields fusion peptide-directed antibodies that neutralize diverse strains of HIV-1

Xu, K. Y., Acharya, P., Kong, R., Cheng, C., Chuang, G., Liu, K., Louder, M. K., O'Dell, S. J., Rawi, R., Sastry, M., et al. (2018) · Nature Medicine · doi:10.1038/s41591-018-0042-6 · Cited by 284 · see citing works

Ebolavirus Glycoprotein Structure and Mechanism of Entry

Lee, J. E., & Saphire, E. O. (2009) · Future Virology · doi:10.2217/fvl.09.56 · Cited by 281 · see citing works

Broadly Protective Monoclonal Antibodies against H3 Influenza Viruses following Sequential Immunization with Different Hemagglutinins

Wang, T. T., Tan, G. S., Hai, R., Pica, N., Petersen, E., Moran, T. M., & Palese, P. (2010) · PLoS Pathogens · doi:10.1371/journal.ppat.1000796 · Cited by 278 · see citing works

Structural and genetic basis for development of broadly neutralizing influenza antibodies

Lingwood, D., McTamney, P. M., Yassine, H. M., Whittle, J. R. R., Guo, X., Boyington, J. C., Wei, C., & Nabel, G. J. (2012) · Nature · doi:10.1038/nature11371 · Cited by 269 · see citing works

Both Neutralizing and Non-Neutralizing Human H7N9 Influenza Vaccine-Induced Monoclonal Antibodies Confer Protection

Henry Dunand, C. J., Leon, P. E., Huang, M., Choi, A., Chromikova, V., Ho, I. Y., Tan, G. S., Cruz, J., Hirsh, A., Zheng, N.-Y., et al. (2016) · Cell Host & Microbe · doi:10.1016/j.chom.2016.05.014 · Cited by 268 · see citing works

Adjuvanted influenza vaccines

Tregoning, J. S., Russell, R. F., & Kinnear, E. (2018) · Human Vaccines & Immunotherapeutics · doi:10.1080/21645515.2017.1415684 · Cited by 263 · see citing works

Cellular origin(s) of chronic lymphocytic leukemia: cautionary notes and additional considerations and possibilities

Chiorazzi, N., & Ferrarini, M. (2010) · Blood · doi:10.1182/blood-2010-07-155663 · Cited by 264 · see citing works

Playing Hide and Seek: How Glycosylation of the Influenza Virus Hemagglutinin Can Modulate the Immune Response to Infection

Tate, M. D., Job, E. R., Deng, Y., Gunalan, V., Maurer‐Stroh, S., & Reading, P. C. (2014) · Viruses · doi:10.3390/v6031294 · Cited by 263 · see citing works

From Original Antigenic Sin to the Universal Influenza Virus Vaccine

Henry, C., Palm, A.-K. E., Krammer, F., & Wilson, P. C. (2017) · Trends in Immunology · doi:10.1016/j.it.2017.08.003 · Cited by 262 · see citing works

Convergent Antibody Signatures in Human Dengue

Parameswaran, P., Liu, Y., Roskin, K. M., Jackson, K., Dixit, V. P., Lee, J.-Y., Artiles, K. L., Zompì, S., Vargas, M. J., Simen, B. B., et al. (2013) · Cell Host & Microbe · doi:10.1016/j.chom.2013.05.008 · Cited by 261 · see citing works

Broadly protective human antibodies that target the active site of influenza virus neuraminidase

Stadlbauer, D., Zhu, X., McMahon, M., Turner, J. S., Wohlbold, T. J., Schmitz, A. J., Strohmeier, S., Yu, W., Nachbagauer, R., Mudd, P. A., et al. (2019) · Science · doi:10.1126/science.aay0678 · Cited by 261 · see citing works

Vaccines: the Fourth Century

Plotkin, S. A. (2009) · Clinical and Vaccine Immunology · doi:10.1128/cvi.00290-09 · Cited by 256 · see citing works

Influenza Hemagglutinin Structures and Antibody RecognitionPreprint

Wu, N. C., & Wilson, I. A. (2019) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a038778 · Cited by 253 · see citing works

Hemagglutinin stalk antibodies elicited by the 2009 pandemic influenza virus as a mechanism for the extinction of seasonal H1N1 viruses

Pica, N., Hai, R., Krammer, F., Wang, T. T., Maamary, J., Eggink, D., Tan, G. S., Krause, J. C., Moran, T. M., Stein, C. R., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1200039109 · Cited by 251 · see citing works

Broadly neutralizing antibodies target the coronavirus fusion peptide

Dacon, C., Tucker, C., Peng, L., Lee, C. D., Lin, T.-H., Yuan, M., Cong, Y., Wang, L.-S., Purser, L., Williams, J. K., et al. (2022) · bioRxiv · doi:10.1126/science.abq3773 · Cited by 242 · see citing works

Flow Cytometry Reveals that H5N1 Vaccination Elicits Cross-Reactive Stem-Directed Antibodies from Multiple Ig Heavy-Chain Lineages

Whittle, J. R. R., Wheatley, A. K., Wu, L., Lingwood, D., Kanekiyo, M., Steven, S., Narpala, S., Yassine, H. M., Frank, G. M., Yewdell, J. W., et al. (2014) · Journal of Virology · doi:10.1128/jvi.03422-13 · Cited by 250 · see citing works

Structurally Resolved SARS-CoV-2 Antibody Shows High Efficacy in Severely Infected Hamsters and Provides a Potent Cocktail Pairing Strategy

Du, S., Cao, Y., Zhu, Q.-Y., Yu, P., Qi, F.-F., Wang, G., Du, X., Bao, L., Deng, W., Zhu, H., et al. (2020) · Cell · doi:10.1016/j.cell.2020.09.035 · Cited by 249 · see citing works

Preconfiguration of the antigen-binding site during affinity maturation of a broadly neutralizing influenza virus antibody

Schmidt, A. G., Xu, H., Khan, A. R., O’Donnell, T. J., Khurana, S., King, L. R., Manischewitz, J. F., Golding, H., Suphaphiphat, P., Carfı́, A., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1218256109 · Cited by 243 · see citing works

A Site of Vulnerability on the Influenza Virus Hemagglutinin Head Domain Trimer Interface

Bangaru, S., Lang, S., Schotsaert, M., Vanderven, H. A., Zhu, X., Kose, N., Bombardi, R. G., Finn, J. A., Kent, S. J., Gilchuk, P., et al. (2019) · Cell · doi:10.1016/j.cell.2019.04.011 · Cited by 246 · see citing works

Functions of Antibodies

Forthal, D. N. (2014) · Microbiology Spectrum · doi:10.1128/microbiolspec.aid-0019-2014 · Cited by 246 · see citing works

Evasion of Influenza A Viruses from Innate and Adaptive Immune Responses

van de Sandt, C. E., Kreijtz, J. H. C. M., & Rimmelzwaan, G. F. (2012) · Viruses · doi:10.3390/v4091438 · Cited by 242 · see citing works

Induction of broadly cross-reactive antibody responses to the influenza HA stem region following H5N1 vaccination in humans

Ellebedy, A. H., Krammer, F., Li, G.-M., Miller, M. S., Chiu, C., Wrammert, J., Chang, C. Y., Davis, C. W., McCausland, M., Elbein, R., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1414070111 · Cited by 234 · see citing works

Cross-Neutralization of 1918 and 2009 Influenza Viruses: Role of Glycans in Viral Evolution and Vaccine Design

Wei, C., Boyington, J. C., Dai, K., Houser, K. V., Pearce, M. B., Kong, W., Yang, Z., Tumpey, T. M., & Nabel, G. J. (2010) · Science Translational Medicine · doi:10.1126/scitranslmed.3000799 · Cited by 232 · see citing works

Common Features of Enveloped Viruses and Implications for Immunogen Design for Next-Generation Vaccines

Rey, F. A., & Lok, S. (2018) · Cell · doi:10.1016/j.cell.2018.02.054 · Cited by 232 · see citing works

The influenza virus hemagglutinin head evolves faster than the stalk domain

Roubidoux, E. K., Qiu, X., Wilson, P. C., Bahl, J., & Krammer, F. (2018) · Scientific Reports · doi:10.1038/s41598-018-28706-1 · Cited by 231 · see citing works

Advanced Point‐of‐Care Testing Technologies for Human Acute Respiratory Virus Detection

Zhang, Z., Ma, P., Ahmed, R., Wang, J., Akin, D., Soto, F., Liu, B., Li, P., & Demirci, U. (2021) · Advanced Materials · doi:10.1002/adma.202103646 · Cited by 231 · see citing works

Vaccine-Induced Anti-HA2 Antibodies Promote Virus Fusion and Enhance Influenza Virus Respiratory Disease

Khurana, S., Loving, C. L., Manischewitz, J. F., King, L. R., Gauger, P. C., Henningson, J. N., Vincent, A. L., & Golding, H. (2013) · Science Translational Medicine · doi:10.1126/scitranslmed.3006366 · Cited by 224 · see citing works

Universal protection against influenza infection by a multidomain antibody to influenza hemagglutinin

Laursen, N. S., Friesen, R. H. E., Zhu, X., Jongeneelen, M. A. C., Blokland, S., Vermond, J., Real, A. V. E.-O., Tang, C., van Diepen, H. A., Obmolova, G., et al. (2018) · Science · doi:10.1126/science.aaq0620 · Cited by 223 · see citing works

Emerging perspectives in the research of bovine babesiosis and anaplasmosis

Suarez, C. E., & Noh, S. M. (2011) · Veterinary Parasitology · doi:10.1016/j.vetpar.2011.05.032 · Cited by 221 · see citing works

Computational Design of Epitope-Scaffolds Allows Induction of Antibodies Specific for a Poorly Immunogenic HIV Vaccine Epitope

Correia, B. E., Ban, Y. A., Holmes, M. A., Xu, H., Ellingson, K., Kraft, Z., Carrico, C., Boni, E., Sather, D. N., Zenobia, C., et al. (2010) · Structure · doi:10.1016/j.str.2010.06.010 · Cited by 218 · see citing works

Production and stabilization of the trimeric influenza hemagglutinin stem domain for potentially broadly protective influenza vaccines

Lu, Y., Welsh, J. P., & Swartz, J. R. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1308701110 · Cited by 216 · see citing works

Entry of influenza A virus: host factors and antiviral targets

Edinger, T. O., Pohl, M. O., & Stertz, S. (2013) · Journal of General Virology · doi:10.1099/vir.0.059477-0 · Cited by 215 · see citing works

Cross-Reactive Influenza-Specific Antibody-Dependent Cellular Cytotoxicity Antibodies in the Absence of Neutralizing Antibodies

Jegaskanda, S., Job, E. R., Kramski, M., Laurie, K., Isitman, G., Rose, R. D., Winnall, W. R., Stratov, I., Brööks, A. G., Reading, P. C., et al. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1201574 · Cited by 215 · see citing works

Design of an HA2-based Escherichia coli expressed influenza immunogen that protects mice from pathogenic challenge

Bommakanti, G., Citron, M. P., Hepler, R. W., Callahan, C., Heidecker, G. J., Najar, T. A., Lu, X., Joyce, J. G., Shiver, J. W., Casimiro, D. R., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1007465107 · Cited by 214 · see citing works

Antibody responses to viral infections: a structural perspective across three different enveloped viruses

Murin, C. D., Wilson, I. A., & Ward, A. B. (2019) · Nature Microbiology · doi:10.1038/s41564-019-0392-y · Cited by 210 · see citing works

Receptor mimicry by antibody F045–092 facilitates universal binding to the H3 subtype of influenza virus

Lee, P. S., Ohshima, N., Stanfield, R. L., Yu, W., Iba, Y., Okuno, Y., Kurosawa, Y., & Wilson, I. A. (2014) · Nature Communications · doi:10.1038/ncomms4614 · Cited by 213 · see citing works

Accurate Measurement of the Effects of All Amino-Acid Mutations on Influenza Hemagglutinin

Doud, M. B., & Bloom, J. D. (2016) · Viruses · doi:10.3390/v8060155 · Cited by 211 · see citing works

A Broadly Neutralizing Human Monoclonal Antibody That Recognizes a Conserved, Novel Epitope on the Globular Head of the Influenza H1N1 Virus Hemagglutinin

Krause, J. C., Tsibane, T., Tumpey, T. M., Huffman, C. J., Basler, C. F., & Crowe, J. E. (2011) · Journal of Virology · doi:10.1128/jvi.00700-11 · Cited by 204 · see citing works

Towards a universal influenza vaccine: different approaches for one goal

Sautto, G. A., Kirchenbaum, G. A., & Ross, T. M. (2018) · Virology Journal · doi:10.1186/s12985-017-0918-y · Cited by 202 · see citing works

Hemagglutinin Stalk-Based Universal Vaccine Constructs Protect against Group 2 Influenza A Viruses

Margine, I., Krammer, F., Hai, R., Heaton, N. S., Tan, G. S., Andrews, S., Runstadler, J. A., Wilson, P. C., Albrecht, R. A., García‐Sastre, A., et al. (2013) · Journal of Virology · doi:10.1128/jvi.01715-13 · Cited by 197 · see citing works

Influenza hemagglutinin stem-fragment immunogen elicits broadly neutralizing antibodies and confers heterologous protection

Mallajosyula, V. V. A., Citron, M. P., Ferrara, F., Lu, X., Callahan, C., Heidecker, G. J., Sarma, S. P., Flynn, J. A., Temperton, N. J., Liang, X., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1402766111 · Cited by 191 · see citing works

Influenza Virus-Mediated Membrane Fusion: Determinants of Hemagglutinin Fusogenic Activity and Experimental Approaches for Assessing Virus Fusion

Hamilton, B. S., Whittaker, G. R., & Daniel, S. (2012) · Viruses · doi:10.3390/v4071144 · Cited by 188 · see citing works

DNA priming and influenza vaccine immunogenicity: two phase 1 open label randomised clinical trials

Ledgerwood, J. E., Wei, C., Hu, Z., Gordon, I. J., Enama, M. E., Hendel, C. S., McTamney, P. M., Pearce, M. B., Yassine, H. M., Boyington, J. C., et al. (2011) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(11)70240-7 · Cited by 188 · see citing works

A Human Antibody Recognizing a Conserved Epitope of H5 Hemagglutinin Broadly Neutralizes Highly Pathogenic Avian Influenza H5N1 Viruses

Hu, H., Voss, J., Zhang, G., Buchy, P., Zuo, T., Wang, L., Wang, F., Zhou, F., Wang, G., Tsai, C., et al. (2012) · Journal of Virology · doi:10.1128/jvi.06665-11 · Cited by 72 · see citing works

Research highlights

(2009) · Nature Biotechnology · doi:10.1038/nbt0409-348

A Highly Conserved Neutralizing Epitope on Group 2 Influenza A Viruses

Ekiert, D. C., Friesen, R. H. E., Bhabha, G., Kwaks, T., Jongeneelen, M. A. C., Yu, W., Ophorst, C., Cox, F., Korse, H. J. W. M., Brandenburg, B., et al. (2011) · Science · doi:10.1126/science.1204839 · Cited by 823 · see citing works

A Virus-Like Particle That Elicits Cross-Reactive Antibodies to the Conserved Stem of Influenza Virus Hemagglutinin

(2016)

An Effective Neutralizing Antibody Against Influenza Virus H1N1 from Human B Cells

Lee, C., Yang, C.-Y., Lin, L., Ko, T., Chang, A., Chang, S. S.-C., & Wang, A. H. ‐. (2019) · Scientific Reports · doi:10.1038/s41598-019-40937-4 · Cited by 22 · see citing works