The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Deciphering the Origin and Evolution of Hepatitis B Viruses by Means of a Family of Non-enveloped Fish Viruses
Open accessAbstract
Hepatitis B viruses (HBVs), which are enveloped viruses with reverse-transcribed DNA genomes, constitute the family Hepadnaviridae. An outstanding feature of HBVs is their streamlined genome organization with extensive gene overlap. Remarkably, the ∼1,100 bp open reading frame (ORF) encoding the envelope proteins is fully nested within the ORF of the viral replicase P. Here, we report the discovery of a diversified family of fish viruses, designated nackednaviruses, which lack the envelope protein gene, but otherwise exhibit key characteristics of HBVs including genome replication via protein-primed reverse-transcription and utilization of structurally related capsids. Phylogenetic reconstruction indicates that these two virus families separated more than 400 million years ago before the rise of tetrapods. We show that HBVs are of ancient origin, descending from non-enveloped progenitors in fishes. Their envelope protein gene emerged de novo, leading to a major transition in viral lifestyle, followed by co-evolution with their hosts over geologic eras.
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A comprehensive phylogeny of birds (Aves) using targeted next-generation DNA sequencing
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Metadata
- Authors
- Lauber, C., Seitz, S., Mattei, S., Suh, A., Beck, J., Herstein, J., Börold, J., Salzburger, W., Kaderali, L., Briggs, J. A. G., & Bartenschlager, R.
- Venue
- Cell Host & Microbe
- Publisher
- Elsevier BV
- Published
- 2017-09
- Volume
- 22
- Issue
- 3
- Pages
- 387-399.e6
- ISSN
- 1931-3128 (ISSN-L)
- OpenAlex
- W2753903906
- Cited by
- 168
- References
- 12
- FWCI
- 10.76
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Lauber, C., Seitz, S., Mattei, S., Suh, A., Beck, J., Herstein, J., Börold, J., Salzburger, W., Kaderali, L., Briggs, J. A. G., & Bartenschlager, R. (2017). Deciphering the Origin and Evolution of Hepatitis B Viruses by Means of a Family of Non-enveloped Fish Viruses. Cell Host & Microbe. https://doi.org/10.1016/j.chom.2017.07.019
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
