Cited by 3,063Genomics and Phylogenetic StudiesRNA and protein synthesis mechanismsEvolution and Genetic Dynamics

ProtTest: selection of best-fit models of protein evolution

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Abascal, F., Zardoya, R., Posada, D.·2005·Bioinformatics

Abstract

SUMMARY: Using an appropriate model of amino acid replacement is very important for the study of protein evolution and phylogenetic inference. We have built a tool for the selection of the best-fit model of evolution, among a set of candidate models, for a given protein sequence alignment. AVAILABILITY: ProtTest is available under the GNU license from http://darwin.uvigo.es

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Crossref · 10.1093/bioinformatics/bti263

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  • Sequence similarity is strictly an empirical observation, whereas homology is a hypothesis intended to explain the similarity.

    “Nonetheless, as I and many others have argued [1,32-40], sequence similarity is strictly an empirical observation; homology, on the other hand, is a hypothesis intended to explain the similarity.”

    From On universal common ancestry, sequence similarity, and phylogenetic structure: the sins of P-values and the virtues of Bayesian evidence (2011) · cites this paper as [32]

    The Abstract (page unavailable) describes selecting models of protein evolution for sequence alignments, but does not distinguish observed sequence similarity from a hypothesis of homology. Searches for the quoted distinction and for homology, common ancestry, and empirical observation found no passage in our copy addressing it. (LLM, conf=0.76)

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Research works printed but not linked: 1

  1. [5]5. Dayhoff,M.O., Schwartz,R.M. and Orcutt,B.C. (1978) A model of evolutionary change in proteins. In: Dayhoff,M.O. (ed.), Atlas of Protein Sequence and Structure National Biomedical Research Foundation, Washington, DC, pp. 345-352.

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Authors
Abascal, F., Zardoya, R., & Posada, D.
Affiliations
  • Universidade de Vigo (ES)
  • Museo Nacional de Ciencias Naturales (ES)
Corresponding author
Abascal, F.
Venue
Bioinformatics
Published
2005-01-12
Volume
21
Issue
9
Pages
2104-2105
ISSN
  • 0266-7061 (ISSN-L)
  • 1367-4803
  • 1460-2059
OpenAlex
W2144654387
Cited by
3,063
References
25
Citations by year
2026: 17 · 2025: 22 · 2024: 40 · 2023: 40 · 2022: 69 · 2021: 82 · 2020: 97 · 2019: 90 · 2018: 153 · 2017: 190 · 2016: 212 · 2015: 230 · 2014: 278 · 2013: 286 · 2012: 267
FWCI
41.69
Type
journal article
Language
en
Open access
Locations
  • Computer applications in the biosciences (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Fundación BBVA
  • Banco Bilbao Vizcaya Argentaria
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Phylogenetic Studies
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
Keywords
amino acid substitution models, model selection, protein evolution, protein sequence alignment, phylogenetic inference, likelihood ratio test
MeSH terms
Algorithms, Amino Acid Sequence, Amino Acids, Computer Graphics, Computer Simulation, DNA Mutational Analysis, Humans, Models, Genetic, Models, Molecular, Molecular Sequence Data, Phylogeny, Proteins, Software, Structure-Activity Relationship, User-Computer Interface, Mutagenesis, Site-Directed, Evolution, Molecular, Amino Acid Substitution, Internet, Sequence Analysis, Protein

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