ProtTest: selection of best-fit models of protein evolution
Open accessAbstract
SUMMARY: Using an appropriate model of amino acid replacement is very important for the study of protein evolution and phylogenetic inference. We have built a tool for the selection of the best-fit model of evolution, among a set of candidate models, for a given protein sequence alignment. AVAILABILITY: ProtTest is available under the GNU license from http://darwin.uvigo.es
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Sequence similarity is strictly an empirical observation, whereas homology is a hypothesis intended to explain the similarity.
“Nonetheless, as I and many others have argued [1,32-40], sequence similarity is strictly an empirical observation; homology, on the other hand, is a hypothesis intended to explain the similarity.”
From On universal common ancestry, sequence similarity, and phylogenetic structure: the sins of P-values and the virtues of Bayesian evidence (2011) · cites this paper as [32]
The Abstract (page unavailable) describes selecting models of protein evolution for sequence alignments, but does not distinguish observed sequence similarity from a hypothesis of homology. Searches for the quoted distinction and for homology, common ancestry, and empirical observation found no passage in our copy addressing it. (LLM, conf=0.76)
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- Authors
- Abascal, F., Zardoya, R., & Posada, D.
- Affiliations
- Universidade de Vigo (ES)
- Museo Nacional de Ciencias Naturales (ES)
- Corresponding author
- Abascal, F.
- Venue
- Bioinformatics
- Publisher
- Oxford University Press (OUP)
- Published
- 2005-01-12
- Volume
- 21
- Issue
- 9
- Pages
- 2104-2105
- ISSN
- 0266-7061 (ISSN-L)
- 1367-4803
- 1460-2059
- OpenAlex
- W2144654387
- Cited by
- 3,063
- References
- 25
- Citations by year
- 2026: 17 · 2025: 22 · 2024: 40 · 2023: 40 · 2022: 69 · 2021: 82 · 2020: 97 · 2019: 90 · 2018: 153 · 2017: 190 · 2016: 212 · 2015: 230 · 2014: 278 · 2013: 286 · 2012: 267
- FWCI
- 41.69
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Computer applications in the biosciences (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Fundación BBVA
- Banco Bilbao Vizcaya Argentaria
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Phylogenetic Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
- Keywords
- amino acid substitution models, model selection, protein evolution, protein sequence alignment, phylogenetic inference, likelihood ratio test
- MeSH terms
- Algorithms, Amino Acid Sequence, Amino Acids, Computer Graphics, Computer Simulation, DNA Mutational Analysis, Humans, Models, Genetic, Models, Molecular, Molecular Sequence Data, Phylogeny, Proteins, Software, Structure-Activity Relationship, User-Computer Interface, Mutagenesis, Site-Directed, Evolution, Molecular, Amino Acid Substitution, Internet, Sequence Analysis, Protein
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