Metabolic, Epigenetic, and Transgenerational Effects of Gut Bacterial Choline Consumption

Fast gapped-read alignment with Bowtie 2

Langmead, B., & Salzberg, S. L. (2012) · Nature Methods · doi:10.1038/nmeth.1923 · Cited by 56,400

A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION

Bligh, E. G., & Dyer, W. J. (1959) · Canadian Journal of Biochemistry and Physiology · doi:10.1139/o59-099 · Cited by 54,751

RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome

Li, B., & Dewey, C. N. (2011) · BMC Bioinformatics · doi:10.1186/1471-2105-12-323 · Cited by 22,179

Introducing mothur: Open-Source, Platform-Independent, Community-Supported Software for Describing and Comparing Microbial Communities

Schloss, P. D., Westcott, S. L., Ryabin, T., Hall, J. R., Hartmann, M., Hollister, E. B., Lesniewski, R. A., Oakley, B. B., Parks, D. H., Robinson, C. J., et al. (2009) · Applied and Environmental Microbiology · doi:10.1128/aem.01541-09 · Cited by 21,481

One-step inactivation of chromosomal genes in Escherichia coli K-12 using PCR products.

Datsenko, K., & Wanner, B. (2000) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.120163297 · Cited by 15,902

A human gut microbial gene catalogue established by metagenomic sequencing

MetaHIT Consortium, Qin, J., Li, R., Raes, J., Arumugam, M., Burgdorf, K. S., Manichanh, C., Nielsen, T., Pons, N., Levenez, F., et al. (2010) · Nature · doi:10.1038/nature08821 · Cited by 11,624

A core gut microbiome in obese and lean twins

Turnbaugh, P. J., Hamady, M., Yatsunenko, T., Cantarel, B. L., Duncan, A., Ley, R. E., Sogin, M. L., Jones, W. J., Roe, B. A., Affourtit, J. P., et al. (2009) · Nature · doi:10.1038/nature07540 · Cited by 7,823

Development of a Dual-Index Sequencing Strategy and Curation Pipeline for Analyzing Amplicon Sequence Data on the MiSeq Illumina Sequencing Platform

Kozich, J. J., Westcott, S. L., Baxter, N. T., Highlander, S. K., & Schloss, P. D. (2013) · Applied and Environmental Microbiology · doi:10.1128/aem.01043-13 · Cited by 7,246

Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease

Wang, Z., Klipfell, E., Bennett, B. J., Koeth, R., Levison, B. S., DuGar, B., Feldstein, A. E., Britt, E. B., Fu, X., Chung, Y.-M., et al. (2011) · Nature · doi:10.1038/nature09922 · Cited by 5,597

Intestinal microbiota metabolism of l-carnitine, a nutrient in red meat, promotes atherosclerosis

Koeth, R. A., Wang, Z., Levison, B. S., Buffa, J. A., Org, E., Sheehy, B. T., Britt, E. B., Fu, X., Wu, Y., Li, L., et al. (2013) · Nature Medicine · doi:10.1038/nm.3145 · Cited by 4,386

Is maternal microbial metabolism an early-life determinant of health?

Romano, K. A., & Rey, F. E. (2018) · Lab Animal · doi:10.1038/s41684-018-0129-1 · Cited by 25

Metformin: Targeting the Metabolo-Epigenetic Link in Cancer Biology

Cuyàs, E., Verdura, S., Martı́n-Castillo, B., & Menéndez, J. A. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2020.620641 · Cited by 23

Role of gut microbe-derived metabolites in cardiometabolic diseases: Systems based approach

Cao, Y., Aquino-Martínez, R., Hutchison, E. R., Allayee, H., Lusis, A. J., & Rey, F. E. (2022) · Molecular Metabolism · doi:10.1016/j.molmet.2022.101557 · Cited by 26

Probiotics and Commensal Bacteria Metabolites Trigger Epigenetic Changes in the Gut and Influence Beneficial Mood Dispositions

Vitetta, L., Bambling, M., & Strodl, E. S. (2023) · Microorganisms · doi:10.3390/microorganisms11051334 · Cited by 24

Gut Microbiota-Related Cellular and Molecular Mechanisms in the Progression of Nonalcoholic Fatty Liver Disease

Park, E., Jeong, J., Won, S., Sharma, S. P., Gebru, Y. A., Ganesan, R., Gupta, H., Suk, K. T., & Kim, D. J. (2021) · Cells · doi:10.3390/cells10102634 · Cited by 22

Reframing Nutritional Microbiota Studies To Reflect an Inherent Metabolic Flexibility of the Human Gut: a Narrative Review Focusing on High-Fat Diets

Sholl, J., Mailing, L. J., & Wood, T. R. (2021) · mBio · doi:10.1128/mbio.00579-21 · Cited by 23

Role of Gut Microbial Metabolites in Ischemic and Non-Ischemic Heart Failure

Hatamnejad, M. R., Medzikovic, L., Dehghanitafti, A., Rahman, B., Vadgama, A., & Eghbali, M. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26052242 · Cited by 24

Parental diet and offspring health: a role for the gut microbiome via epigenetics

Yang, C., Snelson, M., El‐Osta, A., & Marques, F. Z. (2025) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-025-01106-3 · Cited by 22

Habitual Choline Intakes across the Childbearing Years: A Review

Derbyshire, E. J., Obeid, R., & Schön, C. (2021) · Nutrients · doi:10.3390/nu13124390 · Cited by 21

Discovering radical-dependent enzymes in the human gut microbiota

Levin, B. J., & Balskus, E. P. (2018) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2018.09.011 · Cited by 21

Precision strategies for cancer treatment by modifying the tumor-related bacteria

Lu, H., Wang, Q., Liu, W., Wen, Z., & Li, Y. (2021) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-021-11491-9 · Cited by 21

Dietary Impacts on Gestational Diabetes: Connection between Gut Microbiome and Epigenetic Mechanisms

Bankole, T., Winn, H. N., & Li, Y. (2022) · Nutrients · doi:10.3390/nu14245269 · Cited by 22

Social dynamics modeling of chrono-nutrition

Stefano, A. D., Scatà, M., Vijayakumar, S., Angione, C., Corte, A. L., & Lió, P. (2019) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1006714 · Cited by 19

Personalized approach to childhood obesity: Lessons from gut microbiota and omics studies. Narrative review and insights from the 29th European childhood obesity congress

Gawlik, A., Salonen, A., Jian, C., Yanover, C., Antosz, A., Shmoish, M., Wasniewska, M. G., Bereket, A., Wudy, S. A., Hartmann, M. F., et al. (2021) · Pediatric Obesity · doi:10.1111/ijpo.12835 · Cited by 20

Antibiotic-Induced Dysbiosis of the Gut Microbiota Impairs Gene Expression in Gut-Liver Axis of Mice

Liu, P., Zhang, Y., Zhang, Z., Huang, X., Su, X., Yang, S., & Xie, Y. (2023) · Genes · doi:10.3390/genes14071423 · Cited by 19

Insufficient dietary choline aggravates disease severity in a mouse model of Citrobacter rodentium-induced colitis

Ju, T., Kennelly, J. P., Jacobs, R. L., & Willing, B. P. (2020) · British Journal Of Nutrition · doi:10.1017/s0007114520002639 · Cited by 19

Gut microbiota–derived metabolite trimethylamine N-oxide alters the host epigenome through inhibition of S-adenosylhomocysteine hydrolase

Han, J. H., Rey, F. E., & Denu, J. M. (2025) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2025.110521 · Cited by 21

Human Gut Microbiota in Cardiovascular Disease

Ronen, D., Rokach, Y., Abedat, S., Qadan, A., Daana, S., Amir, O., & Asleh, R. (2024) · Comprehensive physiology · doi:10.1002/cphy.c230012 · Cited by 28

Choline metabolism reprogramming mediates an immunosuppressive microenvironment in non-small cell lung cancer (NSCLC) by promoting tumor-associated macrophage functional polarization and endothelial cell proliferation

Xiao, B., Li, G., Gulizeba, H., Liu, H., Sima, X., Zhou, T., & Huang, Y. (2024) · Journal of Translational Medicine · doi:10.1186/s12967-024-05242-3 · Cited by 19

Epigenetic Treatment of Neurodegenerative Ophthalmic Disorders: An Eye Toward the Future

Moos, W. H., Faller, D. V., Glavas, I. P., Harpp, D. N., Irwin, M. H., Kanara, I., Pinkert, C. A., Powers, W. R., Steliou, K., Vavvas, D. G., et al. (2017) · BioResearch open access · doi:10.1089/biores.2017.0036 · Cited by 19

Choline in immunity: a key regulator of immune cell activation and function

Maia, C., Fung, C. W., & Sánchez‐López, E. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1617077 · Cited by 18

Human Respiratory and Gut Microbiomes—Do They Really Contribute to Respiratory Health?

Durack, J., & Christophersen, C. T. (2020) · Frontiers in Pediatrics · doi:10.3389/fped.2020.00528 · Cited by 18

The role of intestinal flora in metabolic dysfunction-associated steatotic liver disease and treatment strategies

Wang, L. J., Sun, J., Chen, S., Sun, Y., Zheng, Y., & Feng, J. C. (2025) · Frontiers in Medicine · doi:10.3389/fmed.2024.1490929 · Cited by 19

Effects of Hesperidin Consumption on the Cardiovascular System in Pre‐ and Stage 1 Hypertensive Subjects: Targeted and Non‐Targeted Metabolomic Approaches (CITRUS Study)

Pla‐Pagà, L., Pedret, A., Valls, R. M., Calderón-Pérez, L., Llauradó, E., Companys, J., Martín‐Luján, F., Moragas, A., Canela-Canela, N., Puiggròs, F., et al. (2021) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202001175 · Cited by 15

The role of microbiota in nonalcoholic fatty liver disease: mechanism of action and treatment strategy

Shen, S., Liu, Y., Wang, N., Huang, Z., & Deng, G. (2025) · Frontiers in Microbiology · doi:10.3389/fmicb.2025.1621583 · Cited by 17

Purification and Characterization of the Choline Trimethylamine-Lyase (CutC)-Activating Protein CutD

Bodea, S., & Balskus, E. P. (2018) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/bs.mie.2018.04.012 · Cited by 15

Molecular mechanisms of non-alcoholic fatty liver disease development

Sall, T. S., Shcherbakova, E. S., Sitkin, S. I., Vakhitov, T., Бакулин, И. Г., & Demyanova, E. V. (2021) · Russian Journal of Preventive Medicine · doi:10.17116/profmed202124041120 · Cited by 14

Ear wound healing in MRL/MpJ mice is associated with gut microbiome composition and is transferable to non-healer mice via microbiome transplantation

Velasco, C., Dunn, C. M., Sturdy, C., Izda, V., Martin, J., Rivas, A., McNaughton, J., & Jeffries, M. A. (2021) · PLoS ONE · doi:10.1371/journal.pone.0248322 · Cited by 13

Pathoepigenetics: The Role of Epigenetic Biomarkers in Disease Pathogenesis

Cacabelos, R. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-813939-4.00005-x · Cited by 12

Meta‐Omics‐ and Metabolic Modeling‐Assisted Deciphering of Human Microbiota Metabolism

Sieow, B. F., Nurminen, T. J., Ling, H., & Chang, M. W. (2019) · Biotechnology Journal · doi:10.1002/biot.201800445 · Cited by 12

Updates and Original Case Studies Focused on the NMR-Linked Metabolomics Analysis of Human Oral Fluids Part I: Emerging Platforms and Perspectives

Grootveld, M. C., Page, G., Bhogadia, M., & Edgar, M. A. (2022) · Applied Sciences · doi:10.3390/app12031235 · Cited by 13

Exploring the interplay between metabolic dysfunction-associated fatty liver disease and gut dysbiosis: Pathophysiology, clinical implications, and emerging therapies

Al‐Busafi, S. A., Alwassief, A., Madian, A., Atalla, H., Alboraie, M. A. A., Elbahrawy, A., & Eslam, M. (2025) · World Journal of Hepatology · doi:10.4254/wjh.v17.i8.108730 · Cited by 10

From bugs to behavior: targeting the gut-brain interface for addiction therapeutics

Ru, Y., Jia, J., Yang, X., Ba, X., Yan, J., Zhang, H., & Zhang, Y. (2025) · Gut Microbes · doi:10.1080/19490976.2025.2569740 · Cited by 10

Prevention of transgenerational transmission of disease susceptibility through perinatal intervention

Nemoto, T., & Sagawa, N. (2023) · Endocrine Journal · doi:10.1507/endocrj.ej23-0381 · Cited by 11

Nurturing development: how a mother's nutrition shapes offspring's brain through the gut

Ionescu, M.-I., Zahiu, C. D. M., Vlad, A., Galoş, F., Pîrcălăbioru, G. G., Zăgrean, A., & O’Mahony, S. M. (2024) · Nutritional Neuroscience · doi:10.1080/1028415x.2024.2349336 · Cited by 11

Exposure to prenatal excess or imbalanced micronutrients leads to long‐term perturbations in one‐carbon metabolism, trimethylamine‐ N ‐oxide and DNA methylation in Wistar rat offspring

Shelp, G. V., Dong, J., Orlov, N. O., Malysheva, O. V., Bender, E. L., Shoveller, A. K. K., Bakovic, M., & Cho, C. E. (2024) · The FASEB Journal · doi:10.1096/fj.202401018rr · Cited by 11

Plasma metabolomics in a deep vein thrombosis rat model based on ultra-high performance liquid chromatography-electrostatic field orbitrap high resolution mass spectrometry

Gu, Y., Zang, P., Li, J., Yan, Y., & Wang, J. (2022) · Chinese Journal of Chromatography · doi:10.3724/sp.j.1123.2021.12024 · Cited by 10

Food and Gut Microbiota-Derived Metabolites in Nonalcoholic Fatty Liver Disease

Jeong, M. K., Min, B. H., Choi, Y. R., Hyun, J. Y., Park, H., Eom, J. A., Won, S. M., Jeong, J., Oh, K., Gupta, H., et al. (2022) · Foods · doi:10.3390/foods11172703 · Cited by 12

Use of Bacillus subtilis PB6 enriched with choline to improve growth performance, immune status, histological parameters and intestinal microbiota of broiler chickens

Abramowicz, K., Krauze, M., & Ognik, K. (2020) · Animal Production Science · doi:10.1071/an18737 · Cited by 9

Mung Bean Peptides Alleviate Dextran-Sulfate-Sodium-Induced Colitis Symptoms in Mice by Protecting the Intestinal Mechanical Barrier and Regulating Gut Microbiota

Xu, C., Diao, J., Feng, Y., Zhang, S., Sheng, Y., & Wang, C. (2025) · Foods · doi:10.3390/foods14081363 · Cited by 9

Microbial metabolites as engines of behavioral variation across animals

Ntiri, E. S., & Wong, A. C.-N. (2025) · Gut Microbes · doi:10.1080/19490976.2025.2501191 · Cited by 10

Exploring the Prevention of Lipid Deposition Caused by High‐Fat Diet and Its Mechanism of Action of Rosa roxburghii Fermented Juice Based on Liver Metabolomics and Gut Microbiota

Meng, D., Wang, P., Zhang, S., Chen, Z., Lai, C., Yi, X., Huang, X., Yu, H., Zhang, M., & Gao, X. (2025) · Food Science & Nutrition · doi:10.1002/fsn3.70449 · Cited by 9

Future Directions in Choline: From Neurodevelopment to Cardiometabolic Health

Paules, E. M., Petry, H. G., Sprinkles, J., & Trujillo‐Gonzalez, I. (2025) · Nutrients · doi:10.3390/nu17223618 · Cited by 9

The role of the gut microbiome and microbial metabolism in mediating opioid-induced changes in the epigenome

Kolli, U., & Roy, S. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1233194 · Cited by 9

A systematic scientometric review of paternal inheritance of acquired metabolic traits

Crisóstomo, L., Oliveira, P. F., & Alves, M. G. (2023) · BMC Biology · doi:10.1186/s12915-023-01744-6 · Cited by 10

Chlorpyrifos Inhibits Intestinal Stem Cell Proliferation and Differentiation at the Acceptable Daily Intake and Disrupts Immune Responses at High Doses

Yuan, X., Wu, F., Cheng, L., Ji, T., Zheng, C., Ma, Y., Jin, Y., Dong, J., Jin, Y., & Fang, B. (2025) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.4c13249 · Cited by 8

Epigenetic modifications of gut microbiota and their potential role in atherosclerosis

Guo, S., Zhao, J., Zhu, R., Fan, Z., Liu, S., & Wu, W. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1638240 · Cited by 9

Effects of raffinose supplementation on growth performance, carcass quality, blood chemistry, gut microbiota, and intestinal morphology in Yellow-feathered broilers

Yushanaji, B., Kamal, M., Baishanbieke, D., Zhu, L., Zhang, P., He, Q., & Li, F. (2025) · Poultry Science · doi:10.1016/j.psj.2025.105888 · Cited by 8

Gut microbiome, a potential modulator of neuroepigenome

Yang, R., Xu, Y., Zhu, F., Ma, X., Fan, T., & Wang, H.-L. (2025) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2025.109961 · Cited by 7

The invisible influence: can endocrine disruptors reshape behaviors across generations?

Damiano, A., Caioni, G., D’Addario, C., Merola, C., Francioso, A., & Amorena, M. (2025) · Stresses · doi:10.3390/stresses5030046 · Cited by 7

Microbiota and nutrition as risk and resiliency factors following prenatal alcohol exposure

Upreti, D., Rouzer, S. K., Bowring, A., Labbe, E., Kumar, R. P., Miranda, R. C., & Mahnke, A. H. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1182635 · Cited by 7

Research Progress on the Role of M6A in Regulating Economic Traits in Livestock

Ren, T., Xu, M. M., Du, X., Wang, Y., Loor, J. J., Lei, L., Gao, W., Du, X., Song, Y., Liu, G., et al. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25158365 · Cited by 6

Methyl donor micronutrients orchestrate lipid metabolism: The role of DNA methylation modification

Han, L., Tian, Q., Han, Q., Yin, Y., Yin, J. L., & Huang, X. (2024) · Journal of Integrative Agriculture · doi:10.1016/j.jia.2024.11.001 · Cited by 6

Epigenetic alterations and microbiota changes in the saliva of individuals with binge-eating spectrum disorders compared with normal weight healthy controls

Mercante, F., Abbaspour, A., Pucci, M., Sabatucci, A., Rania, M., Konstantinidou, F., Gatta, V., Stuppia, L., Cifani, C., Bulik, C. M., et al. (2025) · Life Sciences · doi:10.1016/j.lfs.2025.123695 · Cited by 6

SLC44A1 deficiency impedes myelin development in the central nervous system

Chen, Q., Chen, X., Li, Z., Shao, Q., Huang, H., Zhou, W., Qiu, M. S., Su, Z., Liu, P., & He, C. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.116617 · Cited by 7

Integrative methylome and transcriptome analysis reveals epigenetic regulation of Fusobacterium nucleatum in laryngeal cancer

Yuan, X., Lau, H., Huang, H., Hsueh, C., Gong, H., & Zhou, L. F. (2024) · Microbial Genomics · doi:10.1099/mgen.0.001221 · Cited by 6

Exploring Trimethylaminuria: Genetics and Molecular Mechanisms, Epidemiology, and Emerging Therapeutic Strategies

Sidoti, A., D’Angelo, R., Castagnetti, A., Viciani, E., Scimone, C., Alibrandi, S., & Giannini, G. (2024) · Biology · doi:10.3390/biology13120961 · Cited by 6

Shift of Choline/Betaine Pathway in Recombinant Pseudomonas for Cobalamin Biosynthesis and Abiotic Stress Protection

Balabanova, L., Pentekhina, I., Nedashkovskaya, O. I., Degtyarenko, A. I., Grigorchuk, V. P., Yugay, Y., Vasyutkina, E., Kudinova, O., Seitkalieva, A. V., Slepchenko, L., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232213934 · Cited by 6

A Comprehensive NMR Analysis of Serum and Fecal Metabolites in Familial Dysautonomia Patients Reveals Significant Metabolic Perturbations

Costello, S. M., Cheney, A. M., Waldum, A., Tripet, B., Cotrina-Vidal, M. L., Kaufmann, H., Norcliffe‐Kaufmann, L., Lefcort, F. B., & Copié, V. (2023) · Metabolites · doi:10.3390/metabo13030433 · Cited by 7

Bacterial consortia-The latest arsenal to inflammatory bowel disease bacteriotherapy

Gupta, M., Kapoor, B., & Gulati, M. (2024) · Medicine in Microecology · doi:10.1016/j.medmic.2024.100107 · Cited by 7

Functional characterisation of gut microbiota and metabolism in Type 2 diabetes indicates that Clostridiales and Enterococcus could play a key role in the diseasePreprint

Mora-Ortiz, M., Oregioni, A., & Claus, S. P. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/836114 · Cited by 6

Trimethylamine N-oxide and related metabolites may regulate DNA methylation and trigger cardiovascular disease

Ma, J., Lai, C.-Q., Li, X. S., Wang, M., Wang, Z., Yao, J., Guo, X., Taylor, K. D., Lee, S., Tracy, R. P., et al. (2026) · Clinical Epigenetics · doi:10.1186/s13148-026-02060-w · Cited by 6

The roles of the gut microbiota, metabolites, and epigenetics in the effects of maternal exercise on offspring metabolism

Ren, J., Zhou, L., Li, S., Zhang, Q., & Xiao, X. (2024) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00200.2024 · Cited by 6

Absence of Intestinal Microbiota during Gestation and Lactation Does Not Alter the Metabolic Response to a Western‐type Diet in Adulthood

Lohuis, M. A. M., Werkman, C. C. N., Harmsen, H. J. M., Tietge, U. J. F., & Verkade, H. J. (2018) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201800809 · Cited by 5

Induction of the glycolysis product methylglyoxal on trimethylamine lyase synthesis in the intestinal microbiota from mice fed with choline and dietary fiber

Li, Q., Wu, T., Zhang, M., Chen, H., & Liu, R. (2021) · Food & Function · doi:10.1039/d1fo01481a · Cited by 5

Microbes and mood: innovative biomarker approaches in depression

Green, M., Trivedi, M. H., & Foster, J. A. (2024) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2024.09.002 · Cited by 6

tRNA m1A modification is essential for gut homeostasis and function of group 3 innate lymphoid cells

Li, J., Tang, Z., Chen, Y., Cai, X., Wu, L., Wang, G., Kan, C., Li, B., Su, B., Li, H., et al. (2026) · Cell Discovery · doi:10.1038/s41421-025-00850-9 · Cited by 4

Phenotypic high-throughput screening identifies modulators of gut microbial choline metabolism

Woo, A. Y. M., Sandoval-Espínola, W. J., Bollenbach, M., Wong, A., Sakanaka, M., Zhang, Q., Nieto, V., Rey, F. E., & Balskus, E. P. (2026) · mBio · doi:10.1128/mbio.01172-25 · Cited by 4

Gut microbiota dysbiosis contributes to choline unavailability and NAFLD development

Moradzad, M., Ghaderi, D., Abdi, M., Farshad, S. E., Rahmani, K., & Vahabzadeh, Z. (2025) · Journal of Diabetes & Metabolic Disorders · doi:10.1007/s40200-024-01511-6 · Cited by 4

Differences in gut bacterial community composition between modern and slower-growing broiler breeder lines: Implications of growth selection on microbiome composition

Shterzer, N., Sbehat, Y., Poudel, B., Rothschild, N., Beyioku, O. E., Headrick, J., Petersen, E. M., Druyan, S., & Mills, E. (2023) · Frontiers in Physiology · doi:10.3389/fphys.2023.1151151 · Cited by 4

Choline Theft—An Inside Job

Mora-Ortiz, M., & Claus, S. P. (2017) · Cell Host & Microbe · doi:10.1016/j.chom.2017.08.017 · Cited by 4

The effects of hydrogen-rich water on gut microbiota and related health outcomes: A systematic review

Zaheer, M., Tarnava, A., LeBaron, T. W., Asgharzadeh, F., Saroughi, M., Yaghoubi, A., & Khazaei, M. (2025) · Letters in Drug Design & Discovery · doi:10.1016/j.lddd.2025.100150 · Cited by 3

Heart Failure in the Molecular Era: Redefining Our Understanding of Disease Mechanisms and Perspectives

Mallol-Simmonds, M., Avila, C., Cañete, I., Parra-Lucares, A., Pena-Silva, J., & Bustamante, S. (2026) · Biomedicines · doi:10.3390/biomedicines14020486 · Cited by 4

Understanding the Role of Gut Microbial Enzyme in CMD

Zhuo, Y., Yu, L., Jiang, C., & Wang, K. (2026) · Circulation Research · doi:10.1161/circresaha.125.326979 · Cited by 3

Mass spectrometric based analysis of whole eggs dissolved in formic acid

Wolfer, J. D., Minkoff, B. B., & Sussman, M. R. (2022) · Food Chemistry · doi:10.1016/j.foodchem.2022.134846 · Cited by 3

Distinct N and C cross-feeding networks in a synthetic mouse gut consortiumPreprint

Escriva, P. P., Fuhrer, T., & Sauer, U. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.12.16.472894 · Cited by 3

Guarding the ovarian reserve: Maternal methyl donor supplementation protects against propylparaben-induced ovarian aging in offspring

Wu, Y., Chen, Y., Wang, S., Wu, T., & Zhang, J. (2026) · Reproductive Toxicology · doi:10.1016/j.reprotox.2026.109167 · Cited by 2

Prenatal cadmium exposure and male infertility in mice: A multi-generational mechanistic study

Zhu, H. Y., Xiong, Y., Yuan, Z., Luo, Y., Ouyang, K., Wang, T., Wang, H., Zhang, Y., Zhang, Y., Chang, W., et al. (2026) · Eco-Environment & Health · doi:10.1016/j.eehl.2026.100217 · Cited by 2

The microbiota-gut-brain-epigenome axis as a novel therapeutic target for decoding postpartum depression

Zheng, B., Xiaoming, S. H. E. N., Han, N., Guo, X. D., & Wan, S. (2026) · Frontiers in Medicine · doi:10.3389/fmed.2026.1778348 · Cited by 4

Is choline deficiency an unrecognized factor in necrotizing enterocolitis of preterm infants?

Drenckpohl, D., Christifano, D. N., & Carlson, S. E. (2024) · Pediatric Research · doi:10.1038/s41390-024-03212-5 · Cited by 2

Characterization of trimethylamine metabolic pathways using pseudo-targeted metabolomics

Wang, X.-N., Liu, J., Ji, W.-L., Huo, Z., Liu, L., & Zheng, J. (2025) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2025.116737 · Cited by 2

Methylamine metabolites and progression to kidney failure in type 2 diabetes: an Asian and European prospective study.

Saulnier, P., Liu, J.-J., Croyal, M., de Keizer, J., Wang, J., Zheng, H.-L., Nelson, R. G., Ragot, S., Liu, S., Halimi, J., et al. (2025) · Diabetes & Metabolism · doi:10.1016/j.diabet.2025.101658 · Cited by 2

Gut microbiome community structure correlates with different behavioral phenotypes in the Belyaev Farm-Fox Experiment

Puetz, L., Delmont, T. O., Mitchell, A., Finn, R. D., Zhang, G., Shepeleva, D. V., Kharlamova, A. V., Kukekova, A. V., Trut, L. N., & Gilbert, M. T. P. (2026) · Communications Biology · doi:10.1038/s42003-026-09717-5 · Cited by 2

Maternal nutrition, epigenetic programming and metabolic syndrome

Lee, H. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-816843-1.00010-2 · Cited by 2

The Mighty Microbiota: Regulator of the Human Body

Gupta, P. (2021) · Clinical Research and Clinical Trials · doi:10.31579/2693-4779/048 · Cited by 2

International Symposium on Ruminant Physiology: Developmental epigenetics—Understanding genetic and sexually dimorphic responses to parental diet and outcomes following assisted reproduction

Sinclair, K. D. (2024) · Journal of Dairy Science · doi:10.3168/jds.2024-25811 · Cited by 2

Hepatocyte nuclear factors dynamically regulate triglyceride metabolic reprogramming in metabolic dysfunction-associated steatotic liver disease: Mechanisms and implications

Li, S., Wu, J., Zhou, Y., Wang, C., Xie, L., Liu, S., Su, Y., He, W., Chen, H., Zhong, W.-W., et al. (2025) · World Journal of Hepatology · doi:10.4254/wjh.v17.i10.109898 · Cited by 1

Gut microbe-derived trimethylamine shapes circadian rhythms through the host receptor TAAR5

Mahen, K. K., Massey, W. J., Orabi, D., Brown, A. L., Jaramillo, T. C., Burrows, A. C., Horak, A. J., Dutta, S., Mrdjen, M., Mouannes, N., et al. (2025) · eLife · doi:10.7554/elife.107037.3 · Cited by 4

A targeted metabolomic method to detect epigenetically relevant metabolites

Miro-Blanch, J., Junza, A., Capellades, J., Balvay, A., Maudet, C., Kovatcheva, M., Raineri, S., Rabot, S., Mellor, J., Serrano, M., et al. (2026) · Molecular Metabolism · doi:10.1016/j.molmet.2026.102342 · Cited by 1

Choline and DNA methylation: impact across metabolic, oncogenic and neurodevelopmental disorders

Sareen, S., Bakovic, M., & Cho, C. E. (2026) · Clinical Epigenetics · doi:10.1186/s13148-026-02086-0 · Cited by 3

Dietary Modulation of Gut Microbiome in High Cholesterol Diet–Induced Atherosclerosis

Sebastian, M., Abhirami, S., Amrutha, D. S., Haritha, R. P., Pillai, M. G., & Helen, A. (2026) · Advanced Gut & Microbiome Research · doi:10.1155/agm3/1962908 · Cited by 1

Habitual Ultra-processed Food Intake Is Associated with Gut Dysbiosis and Pro-inflammatory Metabolite Profiles in Korean Patients with IBD

Shon, W., Kim, K. A., Kim, J. S., Kim, B., Im, J., Lee, H. J., Kim, S., Kim, J. W., Kang, H. W., Kim, K. W., et al. (2026) · Digestive Diseases and Sciences · doi:10.1007/s10620-026-10066-w · Cited by 1

Reports from a Healthy Community: the 7th Conference on Beneficial Microbes

Mandel, M. J., Broderick, N. A., Martens, E. C., & Guillemin, K. J. (2018) · Applied and Environmental Microbiology · doi:10.1128/aem.02562-18 · Cited by 1

Gut Microbe-Derived Metabolite Trimethylamine N-Oxide Activates PERK to Drive Mesenchymal Differentiation and FibrosisPreprint

Kim, S.-J., Bale, S., Wan, Q., Gudjonsson, J. E., Hazen, S. L., Harms, P. W., Tsou, P., Khanna, D., Tsoi, L. C., Gupta, N., et al. (2021) · SSRN Electronic Journal · doi:10.2139/ssrn.3912949 · Cited by 1

Integration with epigenetics

Neu, J. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-820590-7.00014-0

The Gut Microbiota and Immunopathophysiology

Aganetti, M. A., Cruz, C. S., Galvão, I., Engel, D. F., Ricci, M. F., & Vieira, A. T. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-820472-6.00128-6

Probióticos – uma espada ou um escudo no desfecho da COVID-19?

de Abreu, J. A. C., de Freitas, N. L., AZEVEDO, P. R. G., & Brandão, F. (2022) · Research Society and Development · doi:10.33448/rsd-v11i4.27165

Faculty Opinions recommendation of Depletion of microbiome-derived molecules in the host using Clostridium genetics.

Tanaka, S. (2019) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.737073674.793568860

Nutritional Epigenetics and Fetal Metabolic Programming

Lee, H. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-91909-8.00032-3

Intestinal-Specific Cyp24a1 Deletion Induces Toll-Like Receptor-4 Expression and Reduces Chemotherapy-Induced Intestinal Injury in MicePreprint

Thianhlun, P. C. K., Sylvester, C. L., Wardill, H. R., Anderson, P., & Stringer, A. M. (2024) · SSRN Electronic Journal · doi:10.2139/ssrn.4809711

Choline Theft—An Inside Job

Mora-Ortiz, M., & Claus, S. P. (2017) · Cell Host & Microbe · doi:10.1016/j.chom.2017.08.017 · Cited by 4

Abstract 19174: Gut Microbial Utilization of Choline Significantly Alters Host Lipid, DNA Methylation, and Hepatic Gene Expression Profiles

Romano, K. A., Campo, A. M.-D., Krautkramer, K. A., Kasahara, K., Vivas, E. I., Denu, J. M., Amador‐Noguez, D., Balskus, E. P., & Rey, F. E. (2016) · Circulation

Is maternal microbial metabolism an early-life determinant of health?

Romano, K. A., & Rey, F. E. (2018) · Lab Animal · doi:10.1038/s41684-018-0129-1 · Cited by 25

Characterization of dietary choline uptake by the gut microbiome reveals choline assimilating microbes and influences on host choline metabolismPreprint

Johnson, E. W., Banuelos, P., Comrie, J. M. C., Richter, A., Le, H. H., & Thompson, S. D. (2026) · Research Square · doi:10.21203/rs.3.rs-8491198/v1

Chemical signaling between gut microbiota and host chromatin: What is your gut really saying?

Krautkramer, K. A., Rey, F. E., & Denu, J. M. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.r116.761577 · Cited by 70