The DOI matches its Crossref record; 93 of the 93 references it cites were found in a registry or an index.
The Landscape of Genetic Content in the Gut and Oral Human Microbiome
Open accessAbstract
Despite substantial interest in the species diversity of the human microbiome and its role in disease, the scale of its genetic diversity, which is fundamental to deciphering human-microbe interactions, has not been quantified. Here, we conducted a cross-study meta-analysis of metagenomes from two human body niches, the mouth and gut, covering 3,655 samples from 13 studies. We found staggering genetic heterogeneity in the dataset, identifying a total of 45,666,334 non-redundant genes (23,961,508 oral, 22,254,436 gut) at the 95% identity level. 50% of all genes were “singletons”, or unique to a single metagenomic sample. Singletons were enriched for different functions (compared to non-singletons) and arose from sub-population specific microbial strains. Overall, these results provide potential bases for the unexplained heterogeneity observed in microbiome-derived human phenotypes. Based on these data we built a resource, which can be accessed at https://microbial-genes.bio.
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A Comprehensive Review on the Role of the Gut Microbiome in Human Neurological Disorders
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Metadata
- Authors
- Tierney, B. T., Yang, Z., Luber, J. M., Beaudin, M., Wibowo, M. C., Baek, C., Mehlenbacher, E., Patel, C. J., & Kostic, A. D.
- Venue
- Cell Host & Microbe
- Publisher
- Elsevier BV
- Published
- 2019-08
- Volume
- 26
- Issue
- 2
- Pages
- 283-295.e8
- ISSN
- 1931-3128 (ISSN-L)
- OpenAlex
- W2967074377
- Cited by
- 346
- References
- 93
- FWCI
- 12.68
- Type
- journal article
- Language
- en
- Open access
- bronze
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