The DOI matches its Crossref record; 87 of the 87 references it cites were found in a registry or an index.
Innate immune and inflammatory responses to SARS-CoV-2: Implications for COVID-19
Open accessAbstract
COVID-19 can result in severe disease characterized by significant immunopathology that is spurred by an exuberant, yet dysregulated, innate immune response with a poor adaptive response. A limited and delayed interferon I (IFN-I) and IFN-III response results in exacerbated proinflammatory cytokine production and in extensive cellular infiltrates in the respiratory tract, resulting in lung pathology. The development of effective therapeutics for patients with severe COVID-19 depends on our understanding of the pathological elements of this unbalanced innate immune response. Here, we review the mechanisms by which SARS-CoV-2 both activates and antagonizes the IFN and inflammatory response following infection, how a dysregulated cytokine and cellular response contributes to immune-mediated pathology in COVID-19, and therapeutic strategies that target elements of the innate response.
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1 retracted
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Cited by
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Bat genomes illuminate adaptations to viral tolerance and disease resistance
Morales, A. E., Dong, Y., Brown, T., Baid, K., Kontopoulos, D. G., Gonzalez, V., Huang, Z., Ahmed, A.-W., Bhuinya, A., Hilgers, L., et al. (2025) · Nature · doi:10.1038/s41586-024-08471-0 · Cited by 78
Metadata
- Authors
- Lowery, S. A., Sariol, A., & Perlman, S.
- Venue
- Cell Host & Microbe
- Publisher
- Elsevier BV
- Published
- 2021-07
- Volume
- 29
- Issue
- 7
- Pages
- 1052-1062
- ISSN
- 1931-3128 (ISSN-L)
- OpenAlex
- W3161424923
- Cited by
- 294
- References
- 87
- FWCI
- 18.07
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Lowery, S. A., Sariol, A., & Perlman, S. (2021). Innate immune and inflammatory responses to SARS-CoV-2: Implications for COVID-19. Cell Host & Microbe. https://doi.org/10.1016/j.chom.2021.05.004
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