The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Characterization of the enhanced infectivity and antibody evasion of Omicron BA.2.75
Open accessAbstract
Recently emerged SARS-CoV-2 Omicron subvariant, BA.2.75, displayed a growth advantage over circulating BA.2.38, BA.2.76, and BA.5 in India. However, the underlying mechanisms for enhanced infectivity, especially compared with BA.5, remain unclear. Here, we show that BA.2.75 exhibits substantially higher affinity for host receptor angiotensin-converting enzyme 2 (ACE2) than BA.5 and other variants. Structural analyses of BA.2.75 spike shows its decreased thermostability and increased frequency of the receptor binding domain (RBD) in the "up" conformation under acidic conditions, suggesting enhanced low-pH-endosomal cell entry. Relative to BA.4/BA.5, BA.2.75 exhibits reduced evasion of humoral immunity from BA.1/BA.2 breakthrough-infection convalescent plasma but greater evasion of Delta breakthrough-infection convalescent plasma. BA.5 breakthrough-infection plasma also exhibits weaker neutralization against BA.2.75 than BA.5, mainly due to BA.2.75's distinct neutralizing antibody (NAb) escape pattern. Antibody therapeutics Evusheld and Bebtelovimab remain effective against BA.2.75. These results suggest BA.2.75 may prevail after BA.4/BA.5, and its increased receptor-binding capability could support further immune-evasive mutations.
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Citations
Cites
Omicron escapes the majority of existing SARS-CoV-2 neutralizing antibodies
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Self-citationStructural and functional analysis of a potent sarbecovirus neutralizing antibody
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Self-citationN-terminal domain antigenic mapping reveals a site of vulnerability for SARS-CoV-2
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N-terminal domain antigenic mapping reveals a site of vulnerability for SARS-CoV-2
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Prospective mapping of viral mutations that escape antibodies used to treat COVID-19
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Self-citation
Cited by
Alarming antibody evasion properties of rising SARS-CoV-2 BQ and XBB subvariants
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Self-citationACE2 binding and antibody evasion in enhanced transmissibility of XBB.1.5
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Self-citationRepeated Omicron exposures override ancestral SARS-CoV-2 immune imprinting
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Self-citation(2024) · doi:10.1038/s41467-024-50286-0 · Cited by 9
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Metadata
- Authors
- Cao, Y., Song, W., Wang, L., Liu, P., Yue, C., Jian, F., Yu, Y., Yisimayi, A., Wang, P., Wang, Y., Zhu, Q., Deng, J., Fu, W., Yu, L., Zhang, N., Wang, J., Xiao, T., An, R., Wang, J., Liu, L., Yang, S., Niu, X., Gu, Q., Shao, F., Hao, X., Meng, B., Gupta, R. K., Jin, R., Wang, Y., Xie, X. S., & Wang, X.
- Venue
- Cell Host & Microbe
- Publisher
- Elsevier BV
- Published
- 2022-11
- Volume
- 30
- Issue
- 11
- Pages
- 1527-1539.e5
- ISSN
- 1931-3128 (ISSN-L)
- OpenAlex
- W4301394219
- Cited by
- 178
- References
- 11
- FWCI
- 19.51
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Cao, Y., Song, W., Wang, L., Liu, P., Yue, C., Jian, F., Yu, Y., Yisimayi, A., Wang, P., Wang, Y., Zhu, Q., Deng, J., Fu, W., Yu, L., Zhang, N., Wang, J., Xiao, T., An, R., Wang, J., . . . Wang, X. (2022). Characterization of the enhanced infectivity and antibody evasion of Omicron BA.2.75. Cell Host & Microbe. https://doi.org/10.1016/j.chom.2022.09.018
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