The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.
Understanding and manipulating the separation in hydrophilic interaction liquid chromatography
Open accessAbstract
Hydrophilic interaction liquid chromatography (HILIC) has emerged as a valuable complimentary technique to reversed-phase (RP), being especially suited for the analysis of polar and ionised solutes, which are difficult to retain in RP. For solutes amenable to both separation mechanisms, HILIC provides a different selectivity to RP, and also offers possibilities as an orthogonal mechanism for 2-dimensional LC when combined with RP. HILIC has further advantages of lower column back pressures, and increased sensitivity with mobile phase evaporative detectors such as electrospray mass spectrometry. This review covers progress in our understanding of the HILIC technique, principally over the last ten years, including the classification of columns, the factors that control retention and selectivity, and attempts to model the separation process and its kinetics.
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Cites
Alpert, A. J. (1990) · Journal of Chromatography A · doi:10.1016/s0021-9673(00)96972-3 · Cited by 1,966
Hydrophilic interaction chromatography
Hemström, P., & Irgum, K. (2006) · Journal of Separation Science · doi:10.1002/jssc.200600199 · Cited by 1,176
Stationary and mobile phases in hydrophilic interaction chromatography: a review
Jandera, P. (2011) · Analytica Chimica Acta · doi:10.1016/j.aca.2011.02.047 · Cited by 707
pH-dependent surface charging and points of zero charge II. Update
Kosmulski, M. (2004) · Journal of Colloid and Interface Science · doi:10.1016/j.jcis.2004.02.029 · Cited by 591
Alpert, A. J. (2008) · Analytical Chemistry · doi:10.1021/ac070997p · Cited by 523
Separation efficiencies in hydrophilic interaction chromatography
Ikegami, T., Tomomatsu, K., Takubo, H., Horie, K., & Tanaka, N. (2008) · Journal of Chromatography A · doi:10.1016/j.chroma.2008.01.075 · Cited by 419
The hydrophobic-subtraction model of reversed-phase column selectivity
SNYDER, L., DOLAN, J., & CARR, P. (2004) · Journal of Chromatography A · doi:10.1016/s0021-9673(04)01480-3 · Cited by 338
Retention and selectivity of stationary phases for hydrophilic interaction chromatography
Guo, Y., & Gaiki, S. (2011) · Journal of Chromatography A · doi:10.1016/j.chroma.2011.06.052 · Cited by 310
Jandera, P., & Janás, P. (2017) · Analytica Chimica Acta · doi:10.1016/j.aca.2017.01.060 · Cited by 309
The hydrophobic-subtraction model of reversed-phase column selectivity
Snyder, L. R., Dolan, J. W., & Carr, P. W. (2004) · Journal of Chromatography A · doi:10.1016/j.chroma.2004.08.121 · Cited by 298
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Metadata
- Authors
- McCalley, D. V.
- Venue
- Journal of Chromatography A
- Publisher
- Elsevier BV
- Published
- 2017-11
- Volume
- 1523
- Pages
- 49-71
- ISSN
- 0021-9673 (ISSN-L)
- OpenAlex
- W2626129445
- Cited by
- 258
- References
- 40
- FWCI
- 12.79
- Type
- journal article
- Language
- en
- Open access
- green
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