Raman Spectroscopy as Process Analytical Tool in Downstream Processing of Biotechnology
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Raman signals are often weaker than those in other spectroscopic methods, leading to challenges in detecting low-concentration analytes.
“Raman signals are often weaker than those in other spectroscopic methods, leading to challenges in detecting low‐concentration analytes [73].”
From Current PAT Landscape in the Downstream Processing of Biopharmaceuticals (2025) · cites this paper as [73]
Advanced Raman spectroscopic techniques depend on expensive instrumentation, often hindering their routine implementation.
“Advanced Raman spectroscopic techniques depend on expensive instrumentation, often hindering their routine implementation.”
From Current PAT Landscape in the Downstream Processing of Biopharmaceuticals (2025) · cites this paper as [73]
Cites
How to pre-process Raman spectra for reliable and stable models?
Bocklitz, T., Walter, A., Hartmann, K., Rösch, P., & Popp, J. (2011) · Analytica Chimica Acta · doi:10.1016/j.aca.2011.06.043 · Cited by 282 · see citing works
Bioreactor monitoring with spectroscopy and chemometrics: a review
Lourenço, N. D., Lopes, J. A., Almeida, C. F., Sarraguça, M. C., & Pinheiro, H. M. (2012) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-012-6073-9 · Cited by 275 · see citing works
Claßen, J., Aupert, F., Reardon, K. F., Solle, D., & Scheper, T. (2017) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-016-0068-x · Cited by 176 · see citing works
Whelan, J., Craven, S., & Glennon, B. (2012) · Biotechnology Progress · doi:10.1002/btpr.1590 · Cited by 159 · see citing works
Analyzing Raman spectroscopic data
Ryabchykov, O., Guo, S., & Bocklitz, T. (2019) · Physical Sciences Reviews · doi:10.1515/psr-2017-0043 · Cited by 74 · see citing works
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Current PAT Landscape in the Downstream Processing of Biopharmaceuticals
Sathiyapriyan, P., Mukherjee, S., Vogel, T., Essen, L., Boerema, D., Vey, M., & Kalina, U. (2025) · Analytical Science Advances · doi:10.1002/ansa.70013 · Cited by 45 · see citing works
- Authors
- Lin, Y. K., Leong, H. Y., Ling, T. C., Lin, D.-Q., & Yao, S.-J.
- Venue
- Chinese Journal of Chemical Engineering
- Publisher
- Elsevier BV
- Published
- 2021-02
- Volume
- 30
- Pages
- 204-211
- ISSN
- 1004-9541
- Cited by
- 35
- References
- 5
- Language
- en
- Funders
- Zhejiang University
- National Natural Science Foundation of China (21878263, 22078286)
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