Pharmaceutical-loaded contact lenses as an ocular drug delivery system: A review of critical lens characterization methodologies with reference to ISO standards
Open accessAbstract
Therapeutic contact lenses for ocular drug delivery have received considerable interest as they can potentially enhance ocular bioavailability, increase patient compliance, and reduce side effects. Along with the successful in vitro and in vivo studies on sustained drug delivery through contact lenses, lens critical properties such as water content, optical transparency and modulus have also been investigated. Aside from issues such as drug stability or burst release, the potential for the commercialization of pharmaceutical-loaded lenses can be limited by the alteration of lens physical and chemical properties upon the incorporation of therapeutic or non-therapeutic components. This review outlines advances in the use of pharmaceutical-loaded contact lenses and their relevant characterization methodologies as a potential ocular drug delivery system from 2010 to 2020, while summarizing current gaps and challenges in this field. A key reference point for this review is the relevant ISO standards on contact lenses, relating to the associated characterization methodologies. The content of this review is categorized based on the chemical, physical and mechanical properties of the loaded lens with the shortcomings of such analytical technologies examined.
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Contact lenses tend to have better compliance and fewer systemic side effects than other methods, but are limited by solubility, soak time, and drug discarded after soaking.
“Contact lenses tend to have better compliance and fewer systemic side effects than other methods, but they are limited by the solubility of the product, the time needed to soak the lens, and the amount of drug that is discarded following soaking.35,122”
From Gene Therapy for Retinal Degenerative Diseases: Progress, Challenges, and Future Directions (2023) · cites this paper as [122]
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Gaudana, R., Ananthula, H. K., Parenky, A., & Mitra, A. K. (2010) · The AAPS Journal · doi:10.1208/s12248-010-9183-3 · Cited by 1,406 · see citing works
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Gene Therapy for Retinal Degenerative Diseases: Progress, Challenges, and Future Directions
Drag, S., Dotiwala, F., & Upadhyay, A. K. (2023) · Investigative Opthalmology & Visual Science · doi:10.1167/iovs.64.7.39 · Cited by 145 · see citing works
Yang, H., Zhang, F., Fan, Y., Zhang, J., Fang, T., Xing, D., Zhen, Y., Nie, Z., Liu, Y., Wang, D., et al. (2024) · Pharmaceutical Research · doi:10.1007/s11095-024-03672-8 · Cited by 14 · see citing works
- Authors
- Nguyen, D. C. T., Dowling, J., Ryan, R., McLoughlin, P., & Fitzhenry, L.
- Affiliations
- Waterford Institute of Technology (IE)
- Bausch + Lomb (United States) (US)
- Corresponding author
- Nguyen, Dan Chau Thuy
- Venue
- Contact Lens and Anterior Eye
- Publisher
- Elsevier BV
- Published
- 2021-12
- Volume
- 44
- Issue
- 6
- Pages
- 101487
- ISSN
- 1367-0484 (ISSN-L)
- OpenAlex
- W3188226100
- Cited by
- 61
- References
- 1
- Citations by year
- 2026: 6 · 2025: 14 · 2024: 13 · 2023: 17 · 2022: 10 · 2021: 1
- FWCI
- 0.90
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Contact Lens and Anterior Eye (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Ocular Surface and Contact Lens
- Health Sciences › Medicine › Ophthalmology › Ocular Infections and Treatments
- Keywords
- therapeutic contact lenses, ocular drug delivery, lens characterization, moisture content, optical transparency, drug stability, burst release, sustained drug release, ocular bioavailability, medication adherence
- MeSH terms
- Contact Lenses, Hydrophilic, Pharmaceutical Preparations, Eye, Humans, Lens, Crystalline, Drug Delivery Systems
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