Ocular drug delivery

Block copolymer micelles for drug delivery: design, characterization and biological significance

Kataoka, K., Harada, A., & Nagasaki, Y. (2001) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(00)00124-1 · Cited by 3,506 · see citing works

Cyclodextrins and their uses: a review

Del Valle, E. M. M. (2004) · Process Biochemistry · doi:10.1016/s0032-9592(03)00258-9 · Cited by 3,375 · see citing works

Cyclodextrins and their pharmaceutical applications

Loftsson, Þ., & Duchêne, D. (2006) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2006.10.044 · Cited by 1,766 · see citing works

Prodrugs: design and clinical applications

Rautio, J., Kumpulainen, H., Heimbach, T., Oliyai, R., Oh, D.-M., Järvinen, T., & Savolainen, J. (2008) · Nature Reviews Drug Discovery · doi:10.1038/nrd2468 · Cited by 1,645 · see citing works

Birth of a new macromolecular architecture: dendrimers as quantized building blocks for nanoscale synthetic polymer chemistry.

Tomalia, D. A. (2005) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2005.01.007 · Cited by 1,115 · see citing works

Challenges and obstacles of ocular pharmacokinetics and drug delivery

Urtti, A. (2006) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2006.07.027 · Cited by 1,003 · see citing works

Permeability of cornea, sclera, and conjunctiva: A literature analysis for drug delivery to the eye

Prausnitz, M. R., & Noonan, J. S. (1998) · Journal of Pharmaceutical Sciences · doi:10.1021/js9802594 · Cited by 630 · see citing works

Recent Perspectives in Ocular Drug Delivery

Gaudana, R., Jwala, J., Boddu, S., & Mitra, A. (2008) · Pharmaceutical Research · doi:10.1007/s11095-008-9694-0 · Cited by 600 · see citing works

Ciliary neurotrophic factor (CNTF) for human retinal degeneration: Phase I trial of CNTF delivered by encapsulated cell intraocular implants

Sieving, P. A., Caruso, R. C., Tao, W., Coleman, H. R., Thompson, D. J. S., Fullmer, K. R., & Bush, R. A. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0600236103 · Cited by 591 · see citing works

Topical Ocular Drug Delivery: Recent Developments and Future Challenges

Lee, V. H. L., & Robinson, J. R. (1986) · Journal of Ocular Pharmacology and Therapeutics · doi:10.1089/jop.1986.2.67 · Cited by 504 · see citing works

Vesicular systems in ocular drug delivery: an overview

Kaur, I. P., Garg, A. B., Singla, A. K., & Aggarwal, D. (2003) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2003.09.016 · Cited by 450 · see citing works

Viral Vectors for Gene Transfer

Walther, W., & Stein, U. (2000) · Drugs · doi:10.2165/00003495-200060020-00002 · Cited by 444 · see citing works

Current and future ophthalmic drug delivery systems

del Amo, E. M., & Urtti, A. O. (2008) · Drug Discovery Today · doi:10.1016/j.drudis.2007.11.002 · Cited by 414 · see citing works

Poly(amidoamine) dendrimers as ophthalmic vehicles for ocular delivery of pilocarpine nitrate and tropicamide

Vandamme, T. F., & Brobeck, L. (2004) · Journal of Controlled Release · doi:10.1016/j.jconrel.2004.09.015 · Cited by 402 · see citing works

Topical and systemic drug delivery to the posterior segments

HUGHES, P., OLEJNIK, O., Chang-Lin, J.-E., & WILSON, C. (2005) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2005.09.004 · Cited by 400 · see citing works

Inner limiting membrane barriers to aav-mediated retinal transduction from the vitreous

Dalkara, D., Kolstad, K. D., Caporale, N., Visel, M., Klimczak, R. R., Schaffer, D. V., & Flannery, J. G. (2009) · Molecular Therapy · doi:10.1038/mt.2009.181 · Cited by 357 · see citing works

Drug transport in corneal epithelium and blood-retina barrier: emerging role of transporters in ocular pharmacokinetics.

Mannermaa, E., Vellonen, K.-S., & Urtti, A. (2006) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2006.07.024 · Cited by 350 · see citing works

Liposomes as an ocular delivery system for acetazolamide: In vitro and in vivo studies

Hathout, R. M., Mansour, S., Mortada, N. D., & Guinedi, A. S. (2007) · AAPS PharmSciTech · doi:10.1208/pt0801001 · Cited by 346 · see citing works

Ocular drug delivery

Ghate, D. A., & Edelhauser, H. F. (2006) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.3.2.275 · Cited by 336 · see citing works

Polyvalent dendrimer glucosamine conjugates prevent scar tissue formation

Shaunak, S., Thomas, S., Gianasi, E., Godwin, A., Jones, E., Teo, I. A., Mireskandari, K., Luthert, P. J., Duncan, R., Patterson, S., et al. (2004) · Nature Biotechnology · doi:10.1038/nbt995 · Cited by 331 · see citing works

Suprachoroidal drug delivery to the back of the eye using hollow microneedles

Patel, S. R., Lin, A. S. P., Edelhauser, H. F., & Prausnitz, M. R. (2011) · Pharmaceutical Research · doi:10.1007/s11095-010-0271-y · Cited by 330 · see citing works

Role of Mucins in the Function of the Corneal and Conjunctival Epithelia

Gipson, I. K., & Argüeso, P. (2003) · International review of cytology · doi:10.1016/s0074-7696(03)31001-0 · Cited by 323 · see citing works

The targeted delivery of cancer drugs across the blood–brain barrier: chemical modifications of drugs or drug-nanoparticles?

Juillerat‐Jeanneret, L. (2008) · Drug Discovery Today · doi:10.1016/j.drudis.2008.09.005 · Cited by 313 · see citing works

Ocular novel drug delivery: impacts of membranes and barriers

Barar, J., Javadzadeh, A., & Omidi, Y. (2008) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.5.5.567 · Cited by 309 · see citing works

Ophthalmic Drug Delivery through Contact Lenses

Gulsen, D., & Chauhan, A. (2004) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.03-0959 · Cited by 305 · see citing works

Biodegradable Implants for Sustained Drug Release in the Eye

Lee, S. S., Hughes, P. M., Ross, A. D., & Robinson, M. R. (2010) · Pharmaceutical Research · doi:10.1007/s11095-010-0159-x · Cited by 288 · see citing works

Importance of the noncorneal absorption route in topical ophthalmic drug delivery.

Ahmed, I., & Patton, T. F. (1985) · PubMed · Cited by 287 · see citing works

Interaction Between Chemicals and Melanin

LARSSON, B. S. (1993) · Pigment Cell Research · doi:10.1111/j.1600-0749.1993.tb00591.x · Cited by 287 · see citing works

Coated Microneedles for Drug Delivery to the Eye

Jiang, J., Gill, H. S., Ghate, D. A., McCarey, B. E., Patel, S. R., Edelhauser, H. F., & Prausnitz, M. R. (2007) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.07-0066 · Cited by 286 · see citing works

Transscleral drug delivery for posterior segment disease

Geroski, D. H., & Edelhauser, H. F. (2001) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(01)00193-4 · Cited by 282 · see citing works

Dispersion of microemulsion drops in HEMA hydrogel: a potential ophthalmic drug delivery vehicle

Gulsen, D., & Chauhan, A. (2005) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2004.11.033 · Cited by 277 · see citing works

Longitudinal Study of Cone Photoreceptors during Retinal Degeneration and in Response to Ciliary Neurotrophic Factor Treatment

Talcott, K. E., Ratnam, K., Sundquist, S. M., Lucero, A. S., Lujan, B. J., Tao, W., Porco, T. C., Roorda, A., & Duncan, J. L. (2010) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.10-6479 · Cited by 276 · see citing works

Ocular drug delivery by liposome–chitosan nanoparticle complexes (LCS-NP)

Diebold, Y., Jarrı́n, M., Sáez, V., Carvalho, E. L. S., Orea, M. J., Calonge, M., Seijo, B., & Alonso, M. J. (2006) · Biomaterials · doi:10.1016/j.biomaterials.2006.11.028 · Cited by 273 · see citing works

Permeability of Retinal Pigment Epithelium: Effects of Permeant Molecular Weight and Lipophilicity

Pitka¨nen, L., Ranta, V.-P., Moilanen, H., & Urtti, A. (2005) · Investigative Opthalmology & Visual Science · doi:10.1167/iovs.04-1051 · Cited by 261 · see citing works

Subconjunctival nano- and microparticles sustain retinal delivery of budesonide, a corticosteroid capable of inhibiting VEGF expression.

Kompella, U., Bandi, N., & Ayalasomayajula, S. (2003) · Investigative Ophthalmology and Visual Science · doi:10.1167/iovs.02-0791 · Cited by 259 · see citing works

Periocular routes for retinal drug delivery

Raghava, S., Hammond, M., & Kompella, U. B. (2004) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.1.1.99 · Cited by 257 · see citing works

Liposome coated with low molecular weight chitosan and its potential use in ocular drug delivery

Li, N., Zhuang, C.-Y., Wang, M., Sun, X., Nie, S., & Pan, W. (2009) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2009.06.020 · Cited by 248 · see citing works

Drug delivery to the retina: challenges and opportunities

Duvvuri, S., Majumdar, S., & Mitra, A. K. (2003) · Expert Opinion on Biological Therapy · doi:10.1517/14712598.3.1.45 · Cited by 238 · see citing works

Intraocular implants for extended drug delivery: Therapeutic applications

Bourges, J., Bloquel, C., Thomas, A., Froussart, F., Bochot, A., Azan, F., Gurny, R., BenEzra, D., & Béhar‐Cohen, F. (2006) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2006.07.026 · Cited by 235 · see citing works

Ionic Surfactant Aggregates in Saline Solutions: Sodium Dodecyl Sulfate (SDS) in the Presence of Excess Sodium Chloride (NaCl) or Calcium Chloride (CaCl2)

Sammalkorpi, M., Karttunen, M., & Haataja, M. (2009) · The Journal of Physical Chemistry B · doi:10.1021/jp901228v · Cited by 235 · see citing works

Intravenously administered gold nanoparticles pass through the blood–retinal barrier depending on the particle size, and induce no retinal toxicity

Kim, J. H., Kim, J. H., Kim, K., Kim, M. H., & Yu, Y. S. (2009) · Nanotechnology · doi:10.1088/0957-4484/20/50/505101 · Cited by 228 · see citing works

Size-dependent disposition of nanoparticles and microparticles following subconjunctival administration

Amrite, A. C., & Kompella, U. B. (2005) · Journal of Pharmacy and Pharmacology · doi:10.1211/jpp.57.12.0005 · Cited by 213 · see citing works

Intrascleral Drug Delivery to the Eye Using Hollow Microneedles

Jiang, J., Moore, J. S., Edelhauser, H. F., & Prausnitz, M. R. (2008) · Pharmaceutical Research · doi:10.1007/s11095-008-9756-3 · Cited by 209 · see citing works

Intravenous transferrin, RGD peptide and dual-targeted nanoparticles enhance anti-VEGF intraceptor gene delivery to laser-induced CNV

Singh, S. R., GROSSNIKLAUS, H. E., Kang, S. J., Edelhauser, H. F., Ambati, B. K., & Kompella, U. B. (2009) · Gene Therapy · doi:10.1038/gt.2008.185 · Cited by 204 · see citing works

Recombinant adeno-associated virus serotype 4 mediates unique and exclusive long-term transduction of retinal pigmented epithelium in rat, dog, and nonhuman primate after subretinal delivery

Weber, M., Rabinowitz, J., Provost, N., Conrath, H., Folliot, S., Briot, D., Chérel, Y., Chenuaud, P., Samulski, J., Moullier, P., et al. (2003) · Molecular Therapy · doi:10.1016/s1525-0016(03)00098-4 · Cited by 203 · see citing works

Acyclovir-containing liposomes for potential ocular delivery

Law, S. L., Huang, K.-J., & Chiang, C. ‐. (2000) · Journal of Controlled Release · doi:10.1016/s0168-3659(99)00192-3 · Cited by 202 · see citing works

In Vivo Gene Transfer to the Mouse Eye Using an HIV-Based Lentiviral Vector; Efficient Long-Term Transduction of Corneal Endothelium and Retinal Pigment Epithelium

Bainbridge, J., Stephens, C., Parsley, K., Demaison, C., Halfyard, A., Thrasher, A., & Ali, R. (2001) · Gene Therapy · doi:10.1038/sj.gt.3301574 · Cited by 197 · see citing works

Self-assembled liquid crystalline nanoparticles as a novel ophthalmic delivery system for dexamethasone: Improving preocular retention and ocular bioavailability

Gan, L., Han, S., Shen, J., Zhu, J., Zhu, C., Zhang, X., & Gan, Y. (2010) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2010.06.015 · Cited by 197 · see citing works

Acetazolamide: future perspective in topical glaucoma therapeutics

Kaur, I. P., Smitha, R., Aggarwal, D., & Kapil, M. (2002) · International Journal of Pharmaceutics · doi:10.1016/s0378-5173(02)00438-6 · Cited by 194 · see citing works

AAV hybrid serotypes: improved vectors for gene delivery

Choi, V., McCarty, D., & Samulski, R. (2005) · Current Gene Therapy · doi:10.2174/1566523054064968 · Cited by 191 · see citing works

Vitreous: A Barrier to Nonviral Ocular Gene Therapy

Peeters, L., Sanders, N. N., Braeckmans, K., Boussery, K., Van de Voorde, J., De Smedt, S. C., & Demeester, J. (2005) · Investigative Opthalmology & Visual Science · doi:10.1167/iovs.05-0165 · Cited by 189 · cited 2× · see citing works

Polyethylene glycol–polyamidoamine dendritic micelle as solubility enhancer and the effect of the length of polyethylene glycol arms on the solubility of pyrene in water

Yang, H., Morris, J. J., & Lopina, S. T. (2004) · Journal of Colloid and Interface Science · doi:10.1016/j.jcis.2003.12.023 · Cited by 185 · see citing works

Transport processes across the rabbit corneal epithelium: a review

Klyce, S. D., & Crosson, C. E. (1985) · Current Eye Research · doi:10.3109/02713688509025145 · Cited by 185 · see citing works

High concentration of dexamethasone in aqueous and vitreous after subconjunctival injection

Weijtens, O., Feron, E. J., Schoemaker, R. C., Cohen, A. F., Lentjes, E. G. W. M., Romijn, F. P. H. T. M., & van Meurs, J. C. (1999) · American Journal of Ophthalmology · doi:10.1016/s0002-9394(99)00129-4 · Cited by 184 · see citing works

Biodegradable Thermoresponsive Hydrogels for Aqueous Encapsulation and Controlled Release of Hydrophilic Model Drugs

Huang, X. B., & Lowe, T. L. (2005) · Biomacromolecules · doi:10.1021/bm050116t · Cited by 181 · see citing works

Binding of Drugs to Eye Melanin Is Not Predictive of Ocular Toxicity

Leblanc, B., Jezequel, S. G., Davies, T., Hanton, G. C., & Taradach, C. (1998) · Regulatory Toxicology and Pharmacology · doi:10.1006/rtph.1998.1243 · Cited by 179 · see citing works

Investigating the movement of intravitreal human serum albumin nanoparticles in the vitreous and retina

Kim, H., Robinson, S. B., & Csaky, K. G. (2009) · Pharmaceutical Research · doi:10.1007/s11095-008-9745-6 · Cited by 174 · see citing works

Transport Barriers in Transscleral Drug Delivery for Retinal Diseases

Kim, S. H., Lutz, R. J., Wang, N. S., & Robinson, M. R. (2007) · Ophthalmic Research · doi:10.1159/000108117 · Cited by 173 · see citing works

Dendrimers as Potential Drug Carriers. Part I. Solubilization of Non-Steroidal Anti-Inflammatory Drugs in the Presence of Polyamidoamine Dendrimers

Yiyun, C., & Xu, T. (2005) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2005.06.010 · Cited by 168 · see citing works

Liposomes in topical drug delivery.

Schaeffer, H. E., & Krohn, D. L. (1982) · PubMed · Cited by 167 · see citing works

Ketorolac entrapped in polymeric micelles: preparation, characterisation and ocular anti-inflammatory studies

Gupta, A. K. (2000) · International Journal of Pharmaceutics · doi:10.1016/s0378-5173(00)00508-1 · Cited by 160 · see citing works

Dispersion of DMPC Liposomes in Contact Lenses for Ophthalmic Drug Delivery

Gulsen, D., Li, C., & Chauhan, A. (2005) · Current Eye Research · doi:10.1080/02713680500346633 · Cited by 159 · see citing works

Long-term Follow-up Results of a Pilot Trial of a Fluocinolone Acetonide Implant to Treat Posterior Uveitis

Jaffe, G. J., McCallum, R. M., Branchaud, B., Skalak, C., Butuner, Z., & Ashton, P. (2005) · Ophthalmology · doi:10.1016/j.ophtha.2005.03.013 · Cited by 158 · see citing works

Drug Transporter and Cytochrome P450 mRNA Expression in Human Ocular Barriers: Implications for Ocular Drug Disposition

Zhang, T., Xiang, C. D., Gale, D. C., Carreiro, S. T., Wu, E. Y., & Zhang, E. Y. (2008) · Drug Metabolism and Disposition · doi:10.1124/dmd.108.021121 · Cited by 156 · see citing works

Colloidal Carriers for Ophthalmic Drug Delivery

Mainardes, R. M., Urban, M. C. C., Cinto, P. O., Khalil, N. M., Chaud, M. V., Evangelista, R. C., & Gremião, M. P. D. (2005) · Current Drug Targets · doi:10.2174/1389450053765914 · Cited by 155 · see citing works

Gene delivery to the eye using adeno-associated viral vectors

Martin, K. R. G., Klein, R. L., & Quigley, H. A. (2002) · Methods · doi:10.1016/s1046-2023(02)00232-3 · Cited by 149 · see citing works

Distribution of peptide transporter PEPT2 mRNA in the rat nervous system

Berger, U. V., & Hediger, M. A. (1999) · Anatomy and Embryology · doi:10.1007/s004290050242 · Cited by 146 · see citing works

Gene therapy progress and prospects: the eye

Bainbridge, J. W., Tan, M. H., & Ali, R. R. (2006) · Gene Therapy · doi:10.1038/sj.gt.3302812 · Cited by 144 · see citing works

Response of Retinoblastoma with Vitreous Tumor Seeding to Adenovirus-Mediated Delivery of Thymidine Kinase Followed by Ganciclovir

Chévez-Barrios, P., Chintagumpala, M., Mieler, W., Paysse, E., Boniuk, M., Kozinetz, C., Hurwitz, M. Y., & Hurwitz, R. L. (2005) · Journal of Clinical Oncology · doi:10.1200/jco.2004.00.1883 · Cited by 143 · see citing works

Antibacterial activity and cytotoxicity of PEGylated poly(amidoamine) dendrimers

Lopez, A. I., Reins, R. Y., McDermott, A. M., Trautner, B. W., & Cai, C. (2009) · Molecular BioSystems · doi:10.1039/b904746h · Cited by 142 · see citing works

Subconjunctivally administered celecoxib-PLGA microparticles sustain retinal drug levels and alleviate diabetes-induced oxidative stress in a rat model

Ayalasomayajula, S. P., & Kompella, U. B. (2005) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2005.02.019 · Cited by 140 · see citing works

A review of implantable intravitreal drug delivery technologies for the treatment of posterior segment eye diseases

Choonara, Y. E., Pillay, V., Danckwerts, M. P., Carmichael, T. R., & du Toit, L. C. (2009) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.21987 · Cited by 139 · see citing works

Cationic Vectors in Ocular Drug Delivery

Rabinovich‐Guilatt, L., Couvreur, P., Lambert, G., & Dubernet, C. (2004) · Journal of drug targeting · doi:10.1080/10611860400015910 · Cited by 139 · see citing works

Vitreous Is a Barrier in Nonviral Gene Transfer by Cationic Lipids and Polymers

Pitkänen, L., Ruponen, M., Nieminen, J., & Urtti, A. (2003) · Pharmaceutical Research · doi:10.1023/a:1023238530504 · Cited by 134 · see citing works

Preparation and evaluation of liposomal formulations of tropicamide for ocular delivery

Nagarsenker, M. S., Londhe, V. Y., & Nadkarni, G. D. (1999) · International Journal of Pharmaceutics · doi:10.1016/s0378-5173(99)00265-3 · Cited by 134 · see citing works

Biodegradable Ocular Inserts for Sustained Delivery of Brimonidine Tartarate: Preparation and In Vitro/In Vivo Evaluation

Aburahma, M. H., & Mahmoud, A. A. K. (2011) · AAPS PharmSciTech · doi:10.1208/s12249-011-9701-3 · Cited by 133 · see citing works

P-glycoprotein expression in human retinal pigment epithelium.

Kennedy, B. G., & Mangini, N. J. (2002) · PubMed · Cited by 130 · see citing works

PLGA–PEG–PLGA hydrogel for ocular drug delivery of dexamethasone acetate

Gao, Y., Sun, Y., Ren, F., & Gao, S. (2010) · Drug Development and Industrial Pharmacy · doi:10.3109/03639041003680826 · Cited by 130 · see citing works

Molecular Evidence and Functional Expression of P-Glycoprotein (MDR1) in Human and Rabbit Cornea and Corneal Epithelial Cell Lines

Dey, S., Patel, J., Anand, B. S., Jain-Vakkalagadda, B., Kaliki, P., Pal, D., Ganapathy, V., & Mitra, A. K. (2003) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.02-1142 · Cited by 128 · see citing works

Topical use of Coenzyme Q10-loaded liposomes coated with trimethyl chitosan: Tolerance, precorneal retention and anti-cataract effect

Zhang, J., & Wang, S. (2009) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2009.01.001 · Cited by 128 · see citing works

Effect of circulation on the disposition and ocular tissue distribution of 20 nm nanoparticles after periocular administration.

Amrite, A. C., Edelhauser, H. F., Singh, S. R., & Kompella, U. B. (2008) · PubMed Central · Cited by 125 · see citing works

In vivo gene delivery into ocular tissues by eye drops of poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) (PEO-PPO-PEO) polymeric micelles

Liaw, J., Chang, S.-F., & Hsiao, F.-C. (2001) · Gene Therapy · doi:10.1038/sj.gt.3301485 · Cited by 125 · see citing works

Topical and systemic absorption in delivery of dexamethasone to the anterior and posterior segments of the eye

Sigurðsson, H. H., Konrádsdóttir, F., Loftsson, Þ., & Stefánsson, E. (2007) · Acta Ophthalmologica Scandinavica · doi:10.1111/j.1600-0420.2007.00885.x · Cited by 122 · see citing works

Dexamethasone transport and ocular delivery from poly(hydroxyethyl methacrylate) gels

KIM, J., & Chauhan, A. (2007) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2007.11.049 · Cited by 120 · see citing works

Distribution of Brimonidine into Anterior and Posterior Tissues of Monkey, Rabbit, and Rat Eyes

Acheampong, A., Shackleton, M., John, B. A., Burke, J. E., Wheeler, L. A., & Tang-Liu, D. D.-S. (2002) · Drug Metabolism and Disposition · doi:10.1124/dmd.30.4.421 · Cited by 120 · see citing works

Lentiviral Gene Transfer of Rpe65 Rescues Survival and Function of Cones in a Mouse Model of Leber Congenital Amaurosis

Bemelmans, A., Kostic, C., Crippa, S. V., Hauswirth, W. W., Lem, J., Munier, F. L., Seeliger, M. W., Wenzel, A., & Arsenijévic, Y. (2006) · PLoS Medicine · doi:10.1371/journal.pmed.0030347 · Cited by 118 · see citing works

Delivery of Ciliary Neurotrophic Factor via Lentiviral-Mediated Transfer Protects Axotomized Retinal Ganglion Cells for an Extended Period of Time

van Adel, B. A., Kostic, C., Déglon, N., Ball, A. K., & Arsenijévic, Y. (2003) · Human Gene Therapy · doi:10.1089/104303403321070801 · Cited by 114 · see citing works

Duane's Ophthalmology

Mannis, M. J. (1993) · American Journal of Ophthalmology · doi:10.1016/s0002-9394(14)71425-4 · Cited by 110 · see citing works

Cyclodextrin microparticles for drug delivery to the posterior segment of the eye: aqueous dexamethasone eye drops

Loftsson, Þ., Hreinsdóttir, D., & Stefánsson, E. (2007) · Journal of Pharmacy and Pharmacology · doi:10.1211/jpp.59.5.0002 · Cited by 110 · see citing works

Adeno-Associated Virus Type 5: Transduction Efficiency and Cell-Type Specificity in the Primate Retina

Lotery, A. J., Yang, G. S., Mullins, R. F., Russell, S. R., Schmidt, M., Stone, E. M., Lindbloom, J. D., Chiorini, J. A., Kotin, R. M., & Davidson, B. L. (2003) · Human Gene Therapy · doi:10.1089/104303403322542301 · Cited by 107 · see citing works

Bovine and Porcine Transscleral Solute Transport: Influence of Lipophilicity and the Choroid–Bruch’s Layer

Cheruvu, N. P. S., & Kompella, U. B. (2006) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.06-0404 · Cited by 107 · see citing works

Nanoparticle applications in ocular gene therapy

Cai, X., Conley, S. M., & Naash, M. I. (2007) · Vision Research · doi:10.1016/j.visres.2007.07.012 · Cited by 106 · see citing works

Preparation and ocular pharmacokinetics of ganciclovir liposomes

Shen, Y., & Tu, J. (2007) · The AAPS Journal · doi:10.1208/aapsj0903044 · Cited by 106 · see citing works

Mechanism of Corneal Permeation of L-Valyl Ester of Acyclovir: Targeting the Oligopeptide Transporter on the Rabbit Cornea

Anand, B. S., & Mitra, A. K. (2002) · Pharmaceutical Research · doi:10.1023/a:1019806411610 · Cited by 105 · see citing works

Ocular gene delivery using lentiviral vectors

Balaggan, K. S., & Ali, R. R. (2011) · Gene Therapy · doi:10.1038/gt.2011.153 · Cited by 104 · see citing works

Molecular Design for Enhancement of Ocular Penetration

Shirasaki, Y. (2007) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.21200 · Cited by 100 · see citing works

Sustained Release of an Anti-Glaucoma Drug: Demonstration of Efficacy of a Liposomal Formulation in the Rabbit Eye

Natarajan, J. V., Chattopadhyay, S., Ang, M., Darwitan, A., Foo, S. E. M., Zhen, M., Koo, M., Wong, T. T. L., & Venkatraman, S. S. (2011) · PLoS ONE · doi:10.1371/journal.pone.0024513 · Cited by 100 · see citing works

Pharmacokinetics of Topical Ocular Drug Delivery: Potential Uses for the Treatment of Diseases of the Posterior Segment and Beyond

Koevary, S. B. (2003) · Current Drug Metabolism · doi:10.2174/1389200033489488 · Cited by 99 · see citing works

Treatment of Experimental Autoimmune Uveoretinitis with Intravitreal Injection of Tacrolimus (FK506) Encapsulated in Liposomes

Zhang, R., He, R., Jiang, Q., Guo, J., Xue, K., & Yuan, Y.-F. (2010) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.09-4373 · Cited by 98 · see citing works

Thermoresponsive hydrogels as a new ocular drug delivery platform to the posterior segment of the eye.

Derwent, J. J. K., & Mieler, W. F. (2008) · PubMed · Cited by 97 · see citing works

Subconjunctivally implantable hydrogels with degradable and thermoresponsive properties for sustained release of insulin to the retina

Misra, G. P., Singh, R. S., Alemán, T. S., Jacobson, S. G., Gardner, T. W., & Lowe, T. L. (2009) · Biomaterials · doi:10.1016/j.biomaterials.2009.08.025 · Cited by 96 · see citing works

Effect of Eye Pigmentation on Transscleral Drug Delivery

Cheruvu, N. P. S., Amrite, A. C., & Kompella, U. B. (2008) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.07-0214 · Cited by 95 · see citing works

Vitreous Penetration of Orally Administered Valacyclovir

Huynh, T. H., Johnson, M. W., Comer, G. M., & Fish, D. N. (2008) · American Journal of Ophthalmology · doi:10.1016/j.ajo.2007.11.016 · Cited by 94 · see citing works

A Nonionic Surfactant/Chitosan Micelle System in an Innovative Eye Drop Formulation

Pepić, I., Hafner, A., Lovrić, J., Pirkić, B., & Filipović‐Grčić, J. (2010) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.22137 · Cited by 94 · see citing works

Inhibition of in vitro VEGF expression and choroidal neovascularization by synthetic dendrimer peptide mediated delivery of a sense oligonucleotide

Marano, R. J., Wimmer, N., Kearns, P. S., Thomas, B. G., Tóth, I., Brankov, M., & Rakoczy, P. E. (2004) · Experimental Eye Research · doi:10.1016/j.exer.2004.06.023 · Cited by 93 · see citing works

Pharmacokinetics and tolerance study of intravitreal injection of dexamethasone-loaded nanoparticles in rabbits

Zhang, L. (2009) · International Journal of Nanomedicine · doi:10.2147/ijn.s6428 · Cited by 93 · see citing works

Subconjunctival Carboplatin in Fibrin Sealant in the Treatment of Transgenic Murine Retinoblastoma

VANQUILL, K., Dioguardi, P. K., TONG, C., Gilbert, J. A., AABERGJR, T., Grossniklaus, H. E., EDELHAUSER, H., & OBRIEN, J. (2005) · Ophthalmology · doi:10.1016/j.ophtha.2004.11.060 · Cited by 91 · see citing works

Recombinant AAV-mediated gene transfer to the retina: gene therapy perspectives

Rolling, F. (2004) · Gene Therapy · doi:10.1038/sj.gt.3302366 · Cited by 90 · see citing works

Kinetics of macromolecules injected into the subretinal space

Marmor, M. F., Negi, A., & Maurice, D. M. (1985) · Experimental Eye Research · doi:10.1016/0014-4835(85)90138-1 · Cited by 90 · see citing works

Ocular Drug Delivery; Impact of in vitro Cell Culture Models.

Barar, J., Asadi, M., Mortazavi‐Tabatabaei, S. A., & Omidi, Y. (2009) · PubMed Central · Cited by 90 · see citing works

Nanosized Dendritic Polyguanidilyated Translocators for Enhanced Solubility, Permeability, and Delivery of Gatifloxacin

Durairaj, C., Kadam, R. S., Chandler, J., Hutcherson, S. L., & Kompella, U. B. (2010) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.10-5388 · Cited by 86 · see citing works

Oral omega-6 essential fatty acid treatment in contact lens associated dry eye

Kokke, K. H., Morris, J. A., & Lawrenson, J. G. (2008) · Contact Lens and Anterior Eye · doi:10.1016/j.clae.2007.12.001 · Cited by 86 · see citing works

Pharmacokinetics of Erythromycin in Rabbit Corneas after Single-Dose Infusion: Role of P-Glycoprotein as a Barrier to in Vivo Ocular Drug Absorption

Dey, S., Gunda, S., & Mitra, A. K. (2004) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.104.069583 · Cited by 85 · see citing works

Micellar solutions of triblock copolymer surfactants with pilocarpine

Pepić, I., Jalšenjak, N., & Jalšenjak, I. (2004) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2003.11.032 · Cited by 84 · see citing works

Stable and efficient intraocular gene transfer using pseudotyped EIAV lentiviral vectors

Balaggan, K. S., Binley, K. E., Esapa, M., Iqball, S., Askham, Z., Kan, O., Tschernutter, M., Bainbridge, J. W., Naylor, S., & Ali, R. R. (2005) · The Journal of Gene Medicine · doi:10.1002/jgm.845 · Cited by 83 · see citing works

Expression of Multidrug Resistance-Associated Protein (MRP) in Human Retinal Pigment Epithelial Cells and Its Interaction with BAPSG, a Novel Aldose Reductase Inhibitor

Aukunuru, J., Sunkara, G., Bandi, N., Thoreson, W. B., & Kompella, U. B. (2001) · Pharmaceutical Research · doi:10.1023/a:1011060705599 · Cited by 82 · see citing works

Preparation and characterization of puerarin–dendrimer complexes as an ocular drug delivery system

Yao, W., Sun, K., Mu, H., Liang, N., Liu, Y., Chen, Y., Liang, R., & Wang, A. (2010) · Drug Development and Industrial Pharmacy · doi:10.3109/03639041003610799 · Cited by 82 · see citing works

Effect of hydroxypropyl beta cyclodextrin complexation on aqueous solubility, stability, and corneal permeation of acyl ester prodrugs of ganciclovir

Tirucherai, G., & Mitra, A. K. (2003) · AAPS PharmSciTech · doi:10.1208/pt040345 · Cited by 81 · see citing works

Suppression and Regression of Choroidal Neovascularization by the Multitargeted Kinase Inhibitor Pazopanib

Takahashi, K. (2009) · Archives of Ophthalmology · doi:10.1001/archophthalmol.2009.27 · Cited by 80 · see citing works

Charged nanoparticles delivery to the eye using hydrogel iontophoresis

Eljarrat‐Binstock, E., Orucov, F., Aldouby, Y., Frucht‐Pery, J., & Domb, A. J. (2007) · Journal of Controlled Release · doi:10.1016/j.jconrel.2007.11.016 · Cited by 78 · see citing works

Effect of 2-Hydroxypropyl-β-cyclodextrin on the Ocular Absorption of Dexamethasone and Dexamethasone Acetate

Usayapant, A., Karara, A. H., & Narurkar, M. M. (1991) · Pharmaceutical Research · doi:10.1023/a:1015838215268 · Cited by 77 · see citing works

Luteinizing hormone-releasing hormone agonist and transferrin functionalizations enhance nanoparticle delivery in a novel bovine ex vivo eye model.

Kompella, U. B., Sundaram, S., Raghava, S., & Escobar, E. R. (2006) · PubMed · Cited by 77 · see citing works

Molecular mechanism involved in the transport of a prodrug dopamine glycosyl conjugate

Dalpiaz, A., Filosa, R., Caprariis, P. D., Conte, G. M., Bortolotti, F., Biondi, C., Scatturin, A., Prasad, P. D., & Pavan, B. (2006) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2006.11.051 · Cited by 76 · see citing works

Drug Elimination Kinetics Following Subconjunctival Injection Using Dynamic Contrast-Enhanced Magnetic Resonance Imaging

Kim, S. H., Csaky, K. G., Wang, N. S., & Lutz, R. J. (2007) · Pharmaceutical Research · doi:10.1007/s11095-007-9408-z · Cited by 74 · see citing works

A primary culture model of rabbit conjunctival epithelial cells exhibiting tight barrier properties

Saha, P., Kim, K.-J., & Lee, V. H. L. (1996) · Current Eye Research · doi:10.3109/02713689608995151 · Cited by 73 · see citing works

Solubilization of tropicamide by hydroxypropyl-β-cyclodextrin and water-soluble polymers: in vitro/in vivo studies

Cappello, B., Carmignani, C., Iervolino, M., Rotonda, M. I. L., & Saettone, M. F. (2001) · International Journal of Pharmaceutics · doi:10.1016/s0378-5173(00)00648-7 · Cited by 72 · see citing works

Role of P-Glycoprotein in Restricting Propranolol Transport in Cultured Rabbit Conjunctival Epithelial Cell Layers

Yang, J. J., Kim, K.-J., & Lee, V. H. L. (2000) · Pharmaceutical Research · doi:10.1023/a:1007508714259 · Cited by 70 · see citing works

Characterization of cyclosporin A transport in cultured rabbit corneal epithelial cells: P-glycoprotein transport activity and binding to cyclophilin.

Kawazu, K., Yamada, K., Nakamura, M., & Ota, A. (1999) · PubMed · Cited by 70 · see citing works

Interactions of the Dipeptide Ester Prodrugs of Acyclovir with the Intestinal Oligopeptide Transporter: Competitive Inhibition of Glycylsarcosine Transport in Human Intestinal Cell Line-Caco-2

Anand, B. S., Patel, J., & Mitra, A. K. (2003) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.102.044313 · Cited by 70 · see citing works

Characterization of Human Corneal Epithelial Cell Model As a Surrogate for Corneal Permeability Assessment: Metabolism and Transport

Xiang, C. D., Batugo, M. R., Gale, D. C., Zhang, T., Ye, J., Li, C., Zhou, S., Wu, E. Y., & Zhang, E. Y. (2009) · Drug Metabolism and Disposition · doi:10.1124/dmd.108.026286 · Cited by 70 · see citing works

Existence of a p-glycoprotein drug efflux pump in cultured rabbit conjunctival epithelial cells.

Saha, P., Yang, J. J., & Lee, V. H. L. (1998) · PubMed · Cited by 68 · see citing works

Dipeptide Monoester Ganciclovir Prodrugs for Treating HSV-1-Induced Corneal Epithelial and Stromal Keratitis: In Vitro and In Vivo Evaluations

Majumdar, S., Nashed, Y. E., Patel, K., Jain, R., Itahashi, M., Neumann, D. M., Hill, J. M., & Mitra, A. K. (2005) · Journal of Ocular Pharmacology and Therapeutics · doi:10.1089/jop.2005.21.463 · Cited by 68 · see citing works

P-Glycoprotein expression in human retinal pigment epithelium cell lines

Constable, P. A., Lawrenson, J. G., Dolman, D. E. M., Arden, G. B., & Abbott, N. J. (2006) · Experimental Eye Research · doi:10.1016/j.exer.2005.10.029 · Cited by 68 · see citing works

Freeze-fracture quantitative comparison of rabbit corneal epithelial and endothelial membranes

McLaughlin, B. J., Caldwell, R. B., Sasaki, Y., & Wood, T. O. (1985) · Current Eye Research · doi:10.3109/02713689509000002 · Cited by 68 · see citing works

Topically effective ocular hypotensive acetazolamide and ethoxyzolamide formulations in rabbits

Loftsson, Þ., Friðriksdóttir, H., Stefánsson, E., Thórisdóttir, S., Gudmundsson, Ó. S., & Sigthórsson, T. (1994) · Journal of Pharmacy and Pharmacology · doi:10.1111/j.2042-7158.1994.tb03835.x · Cited by 65 · see citing works

The growth factor response in ischemic rat retina and superior colliculus after brimonidine pre-treatment

Lönngren, U., Näpänkangas, U., Lafuente, M. P., Mayor, S., Lindqvist, N., Vidal‐Sanz, M., & Hallböök, F. (2006) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2006.09.005 · Cited by 65 · see citing works

Intravitreal Pharmacokinetics of Plain and Liposome-Entrapped Fluconazole in Rabbit Eyes

Gupta, S. K., Velpandian, T., Dhingra, N., & Jaiswal, J. K. (2000) · Journal of Ocular Pharmacology and Therapeutics · doi:10.1089/jop.2000.16.511 · Cited by 64 · see citing works

Current prodrug strategies via membrane transporters/receptors

Anand, B. S., Dey, S., & Mitra, A. K. (2002) · Expert Opinion on Biological Therapy · doi:10.1517/14712598.2.6.607 · Cited by 63 · see citing works

Ocular Distribution of Intravenously Administered Lipid Formulations of Amphotericin B in a Rabbit Model

Goldblum, D., Rohrer, K., Frueh, B. E., Theurillat, R., Thormann, W., & Zimmerli, S. (2002) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.46.12.3719-3723.2002 · Cited by 63 · see citing works

Effluxing ABC transporters in human corneal epithelium

Vellonen, K., Mannermaa, E., Turner, H. C., Häkli, M., Wolosin, J. M., Tervo, T., Honkakoski, P., & Urtti, A. O. (2009) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.21878 · Cited by 62 · see citing works

Beta-cyclodextrins as vehicles in eye-drop formulations: an evaluation of their effects on rabbit corneal epithelium.

Jansen, T., Xhonneux, B., Mesens, J., & Borgers, M. J. (1990) · PubMed · Cited by 60 · see citing works

In Vitro Corneal Permeability of Diclofenac Sodium in Formulations Containing Cyclodextrins Compared to the Commercial Product Voltaren Ophtha

Reer, O., Bock, T. K., & Müller, B. W. (1994) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.2600830928 · Cited by 60 · see citing works

Pharmacokinetics and Posterior Segment Biodistribution of ESBA105, an Anti–TNF-α Single-Chain Antibody, upon Topical Administration to the Rabbit Eye

Furrer, E., Berdugo, M., Stella, C., Béhar‐Cohen, F., Gurny, R., Feige, U., Lichtlen, P., & Urech, D. (2009) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.08-2370 · Cited by 59 · see citing works

Studies with an Orally Bioavailable αV Integrin Antagonist in Animal Models of Ocular Vasculopathy: Retinal Neovascularization in Mice and Retinal Vascular Permeability in Diabetic Rats

Santulli, R. J., Kinney, W. A., Ghosh, S., DeCorte, B. L., Liu, L., Tuman, R. W., Zhao, Z., Huebert, N. D., Bursell, S. E., Clermont, A. C., et al. (2007) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.107.131656 · Cited by 59 · see citing works

Molecular evidence and functional expression of a novel drug efflux pump (ABCC2) in human corneal epithelium and rabbit cornea and its role in ocular drug efflux

Karla, P. K., Pal, D., Quinn, T., & Mitra, A. K. (2006) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2006.11.031 · Cited by 59 · see citing works

Stable RAAV-Mediated Transduction of Rod and Cone Photoreceptors in the Canine Retina

Bainbridge, J. W. B., Mistry, A., Schlichtenbrede, F. C., Smith, A., Broderick, C., De Alwis, M., Georgiadis, A., Taylor, P. M., Squires, M., Sethi, C., et al. (2003) · Gene Therapy · doi:10.1038/sj.gt.3301990 · Cited by 58 · see citing works

Molecular Expression and Functional Evidence of a Drug Efflux Pump (BCRP) in Human Corneal Epithelial Cells

Karla, P. K., Earla, R., Boddu, S. H., Johnston, T. P., Pal, D., & Mitra, A. K. (2009) · Current Eye Research · doi:10.1080/02713680802518251 · Cited by 58 · see citing works

Identification of a Na+-Dependent Cationic and Neutral Amino Acid Transporter, B0,+, in Human and Rabbit Cornea

Jain-Vakkalagadda, B., Pal, D., Gunda, S., Nashed, Y. E., Ganapathy, V., & Mitra, A. K. (2004) · Molecular Pharmaceutics · doi:10.1021/mp0499499 · Cited by 57 · see citing works

Subconjunctival Topotecan in Fibrin Sealant in the Treatment of Transgenic Murine Retinoblastoma

Tsui, J. Y., Dalgard, C. L., Quill, K. R. V., Lee, L., Grossniklaus, H. E., Edelhauser, H. F., & O’Brien, J. M. (2008) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.07-0653 · Cited by 57 · see citing works

Ultrasound-Enhanced Transcorneal Drug Delivery

Zderic, V., Clark, J. I., Martin, R. W., & Vaezy, S. (2004) · Cornea · doi:10.1097/01.ico.0000134189.33549.cc · Cited by 57 · see citing works

Binding of Betaxolol, Metoprolol and Oligonucleotides to Synthetic and Bovine Ocular Melanin, and Prediction of Drug Binding to Melanin in Human Choroid-Retinal Pigment Epithelium

Pitkänen, L., Ranta, V., Moilanen, H., & Urtti, A. O. (2007) · Pharmaceutical Research · doi:10.1007/s11095-007-9342-0 · Cited by 56 · see citing works

Expression and Localization of Carnitine/Organic Cation Transporter OCTN1 and OCTN2 in Ocular Epithelium

Garrett, Q., Xu, S., Simmons, P. A., Vehige, J. G., Flanagan, J., & Willcox, M. D. P. (2008) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.07-1528 · Cited by 55 · see citing works

Doxycycline-Mediated Inhibition of Choroidal Neovascularization

Samtani, S., Amaral, J., Campos, M. M., Fariss, R. N., & Becerra, S. P. (2009) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.08-3174 · Cited by 55 · see citing works

Transscleral Diffusion of Carboplatin

Simpson, A. E. (2002) · Archives of Ophthalmology · doi:10.1001/archopht.120.8.1069 · Cited by 55 · see citing works

Identification and Functional Characterization of a Na + -Independent Large Neutral Amino Acid Transporter, LAT1, in Human and Rabbit Cornea

Jain-Vakkalagadda, B., Dey, S., Pal, D., & Mitra, A. K. (2003) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.02-0907 · Cited by 54 · see citing works

Modulation of P-Glycoprotein–Mediated Efflux by Prodrug Derivatization: An Approach Involving Peptide Transporter–Mediated Influx Across Rabbit Cornea

Katragadda, S., Talluri, R. S., & Mitra, A. K. (2006) · Journal of Ocular Pharmacology and Therapeutics · doi:10.1089/jop.2006.22.110 · Cited by 54 · see citing works

Lentiviral-vector-mediated expression of murine IL-1 receptor antagonist or IL-10 reduces the severity of endotoxin-induced uveitis

Trittibach, P. C., Barker, S. E., Broderick, C. A., Natkunarajah, M., Durán, Y., Robbie, S. J., Bainbridge, J. W., Smith, A. J., Sarra, G., Dick, A. D., et al. (2008) · Gene Therapy · doi:10.1038/gt.2008.109 · Cited by 54 · see citing works

Corneal Absorption and Anterior Chamber Pharmacokinetics of Dipeptide Monoester Prodrugs of Ganciclovir (GCV): In Vivo Comparative Evaluation of These Prodrugs with Val-GCV and GCV in Rabbits

Gunda, S., Hariharan, S., & Mitra, A. K. (2006) · Journal of Ocular Pharmacology and Therapeutics · doi:10.1089/jop.2006.22.465 · Cited by 52 · see citing works

Treatment of cytomegalovirus retinitis in AIDS patients with intravitreal ganciclovir.

Ausayakhun, S., Yuvaves, P., Ngamtiphakom, S., & Prasitsilp, J. (2005) · PubMed · Cited by 52 · see citing works

Vitreal Pharmacokinetics of Biotinylated Ganciclovir: Role of Sodium-Dependent Multivitamin Transporter Expressed on Retina

Janoria, K. G., Boddu, S. H. S., Wang, Z., Paturi, D., Samanta, S., Pal, D., & Mitra, A. K. (2009) · Journal of Ocular Pharmacology and Therapeutics · doi:10.1089/jop.2008.0040 · Cited by 51 · see citing works

Intravitreal toxicology and duration of efficacy of a novel antiviral lipid prodrug of ganciclovir in liposome formulation.

Cheng, L., Hostetler, K. Y., Chaidhawangul, S., Gardner, M. F., Beadle, J. R., Keefe, K., Bergeron-Lynn, G., SEVERSON, G. M., Soules, K. A., Mueller, A. J., et al. (2000) · PubMed · Cited by 49 · see citing works

Synthesis, metabolism and cellular permeability of enzymatically stable dipeptide prodrugs of acyclovir

Talluri, R. S., Samanta, S., Gaudana, R., & Mitra, A. K. (2008) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2008.05.024 · Cited by 49 · see citing works

Considerations in the use of hydroxypropyl-β-cyclodextrin in the formulation of aqueous ophthalmic solutions of hydrocortisone

Bary, A. R. (2000) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/s0939-6411(00)00108-9 · Cited by 49 · see citing works

Prolonged Transgene Expression with Lentiviral Vectors in the Aqueous Humor Outflow Pathway of Nonhuman Primates

Barraza, R., Rasmussen, C. A., Loewen, N. A., Cameron, J. D., Gabelt, B. T., Teo, W., Kaufman, P. L., & Poeschla, E. M. (2009) · Human Gene Therapy · doi:10.1089/hum.2008.086 · Cited by 48 · see citing works

Preservation of aqueous outflow facility after second-generation FIV vector-mediated expression of marker genes in anterior segments of human eyes.

Loewen, N. A., Bahler, C. K., Teo, W., Whitwam, T., Peretz, M., Xu, R., Fautsch, M. P., Johnson, D. H., & Poeschla, E. M. (2002) · PubMed · Cited by 47 · see citing works

Corneal Permeation of Ganciclovir: Mechanism of Ganciclovir Permeation Enhancement by Acyl Ester Prodrug Design

Tirucherai, G., Dias, C. S., & Mitra, A. K. (2002) · Journal of Ocular Pharmacology and Therapeutics · doi:10.1089/108076802321021081 · Cited by 47 · see citing works

Concentrations of Betaxolol in Ocular Tissues of Patients with Glaucoma and Normal Monkeys after 1 Month of Topical Ocular Administration

Holló, G., Whitson, J. T., Faulkner, R. D., McCue, B. A., Curtis, M., Wieland, H., Chastain, J. E., Sanders, M., DeSantis, L. M., Przydryga, J., et al. (2005) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.05-0945 · Cited by 47 · see citing works

Expression of Multidrug Resistance Associated Protein 5 (MRP5) on Cornea and Its Role in Drug Efflux

Karla, P. K., Quinn, T., Herndon, B., Thomas, P., Pal, D., & Mitra, A. K. (2009) · Journal of Ocular Pharmacology and Therapeutics · doi:10.1089/jop.2008.0084 · Cited by 47 · see citing works

Drug Delivery to the Eye

Mitra, A. K., Anand, B. S., & Duvvuri, S. (2005) · Advances in organ biology · doi:10.1016/s1569-2590(05)10012-3 · Cited by 46 · see citing works

Transcorneal Permeation of l- and d-Aspartate Ester Prodrugs of Acyclovir: Delineation of Passive Diffusion Versus Transporter Involvement

Majumdar, S., Hingorani, T., Srirangam, R., Gadepalli, R. S., Rimoldi, J. M., & Repka, M. A. (2008) · Pharmaceutical Research · doi:10.1007/s11095-008-9730-0 · Cited by 46 · see citing works

<i>In Vitro</i> Evaluation of a Targeted and Sustained Release System for Retinoblastoma Cells Using Doxorubicin as a Model Drug

Boddu, S. H. S., Jwala, J., Chowdhury, M. R., & Mitra, A. K. (2010) · Journal of Ocular Pharmacology and Therapeutics · doi:10.1089/jop.2010.0048 · Cited by 46 · see citing works

Ocular Pharmacokinetics of Cephalosporins using Microdialysis

Macha, S., & Mitra, A. K. (2001) · Journal of Ocular Pharmacology and Therapeutics · doi:10.1089/108076801753266866 · Cited by 46 · see citing works

Long-Term, Targeted Genetic Modification of the Aqueous Humor Outflow Tract Coupled with Noninvasive Imaging of Gene Expression In Vivo

Loewen, N. A., Fautsch, M. P., Teo, W., Bahler, C. K., Johnson, D. H., & Poeschla, E. M. (2004) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.04-0366 · Cited by 46 · see citing works

Transcorneal Iontophoresis for Delivery of Ciprofloxacin Hydrochloride

Vaka, S. R. K., Sammeta, S. M., Day, L. B., & Murthy, S. N. (2008) · Current Eye Research · doi:10.1080/02713680802270945 · Cited by 46 · see citing works

Functional and molecular analysis of d-serine transport in retinal Müller cells

Dun, Y., Mysona, B. A., Itagaki, S., Martin-Studdard, A., Ganapathy, V., & Smith, S. B. (2006) · Experimental Eye Research · doi:10.1016/j.exer.2006.09.015 · Cited by 46 · see citing works

Amino acid prodrugs of acyclovir as possible antiviral agents against ocular HSV-1 infections: Interactions with the neutral and cationic amino acid transporter on the corneal epithelium

Anand, B. S., Katragadda, S., Nashed, Y. E., & Mitra, A. K. (2004) · Current Eye Research · doi:10.1080/02713680490504614 · Cited by 46 · see citing works

Down-regulation of NOSII gene expression by iontophoresis of anti-sense oligonucleotide in endotoxin-induced uveitis

Voigt, M., de Kozak, Y., Halhal, M., Courtois, Y., & Béhar‐Cohen, F. (2002) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(02)00656-3 · Cited by 45 · see citing works

Effect of P-glycoprotein on the ocular disposition of a model substrate, quinidine

Duvvuri, S., Gandhi, M. D., & Mitra, A. K. (2003) · Current Eye Research · doi:10.1076/ceyr.27.6.345.18187 · Cited by 45 · see citing works

Pharmacokinetic Study of Dexamethasone Disodium Phosphate using Intravitreal, Subconjunctival, and Intravenous Delivery Routes in Rabbits

Hosseini, K., Matsushima, D., Johnson, J. A., Widera, G., Nyam, K., Kim, L., Xu, Y., Yao, Y., & Cormier, M. (2008) · Journal of Ocular Pharmacology and Therapeutics · doi:10.1089/jop.2007.0117 · Cited by 45 · see citing works

Vitreous Penetration of Orally Administered Famciclovir

Chong, D. Y., Johnson, M. W., Huynh, T. H., Hall, E. F., Comer, G. M., & Fish, D. N. (2009) · American Journal of Ophthalmology · doi:10.1016/j.ajo.2009.02.010 · Cited by 45 · see citing works

Expression of ABC-Transporters in Human Corneal Tissue and the Transformed Cell Line, HCE-T

Becker, U., Ehrhardt, C., Schneider‐Daum, N., Baldes, C., Schaefer, U. F., Ruprecht, K. W., Kim, K., & Lehr, C. (2007) · Journal of Ocular Pharmacology and Therapeutics · doi:10.1089/jop.2006.0095 · Cited by 45 · see citing works

Widespread expression of an exogenous gene in the eye after intravenous administration.

Zhu, C., Zhang, Y., & Pardridge, W. M. (2002) · PubMed · Cited by 44 · see citing works

Sustained Subconjunctival Protein Delivery Using a Thermosetting Gel Delivery System

Rieke, E. R., Amaral, J., Becerra, S. P., & Lutz, R. J. (2010) · Journal of Ocular Pharmacology and Therapeutics · doi:10.1089/jop.2009.0059 · Cited by 44 · see citing works

Transscleral permeability and intraocular concentrations of cisplatin from a collagen matrix

Gilbert, J. A., Simpson, A. E., Rudnick, D. E., Geroski, D. H., Aaberg, T. M., & Edelhauser, H. F. (2003) · Journal of Controlled Release · doi:10.1016/s0168-3659(03)00151-2 · Cited by 44 · see citing works

OCULAR SIDE EFFECTS ASSOCIATED WITH PERIBULBAR INJECTIONS OF TRIAMCINOLONE ACETONIDE FOR DIABETIC MACULAR EDEMA

Chew, E. Y., Glassman, A. R., Beck, R. W., Bressler, N. M., Fish, G. E., Ferris, F. L., & Kinyoun, J. L. (2010) · Retina · doi:10.1097/iae.0b013e3181f049a8 · Cited by 44 · see citing works

Penetration of moxifloxacin into the human aqueous humour after oral administration

Kampougeris, G. (2005) · British Journal of Ophthalmology · doi:10.1136/bjo.2004.050054 · Cited by 44 · see citing works

Novel Nanoparticulate Gel Formulations of Steroids for the Treatment of Macular Edema

Boddu, S. H. S., Jwala, J., Vaishya, R. D., Earla, R., Karla, P. K., Pal, D., & Mitra, A. K. (2010) · Journal of Ocular Pharmacology and Therapeutics · doi:10.1089/jop.2009.0074 · Cited by 42 · see citing works

Methylprednisolone Delivery to the Back of the Eye using Hydrogel Iontophoresis

Eljarrat‐Binstock, E., Orucov, F., Frucht‐Pery, J., Pe’er, J., & Domb, A. J. (2008) · Journal of Ocular Pharmacology and Therapeutics · doi:10.1089/jop.2007.0097 · Cited by 42 · see citing works

Methotrexate Delivery to the Eye Using Transscleral Hydrogel Iontophoresis

Eljarrat‐Binstock, E., Domb, A. J., Orucov, F., Frucht‐Pery, J., & Pe’er, J. (2007) · Current Eye Research · doi:10.1080/02713680701528674 · Cited by 42 · see citing works

Aqueous and Vitreous Penetration of Levofloxacin after Topical and/or Oral Administration

Sakamoto, H., Sakamoto, M., Hata, Y., Kubota, T., & Ishibashi, T. (2007) · European Journal of Ophthalmology · doi:10.1177/112067210701700316 · Cited by 40 · see citing works

Transcorneal Permeation in a Corneal Device of Non-Steroidal Anti-Inflammatory Drugs in Drug Delivery Systems

Valls, R., Vega, E., García, M. L., Egea, M. A., & Vall�s, J. (2008) · The Open Medicinal Chemistry Journal · doi:10.2174/1874104500802010066 · Cited by 40 · see citing works

Effect of hydrophobic and hydrophilic additives on sol–gel transition and release behavior of timolol maleate from polycaprolactone-based hydrogel

Mishra, G. P., Tamboli, V., & Mitra, A. K. (2011) · Colloid & Polymer Science · doi:10.1007/s00396-011-2476-y · Cited by 40 · see citing works

Mechanism of L-Ascorbic Acid Uptake by Rabbit Corneal Epithelial Cells: Evidence for the Involvement of Sodium-Dependent Vitamin C Transporter 2

Talluri, R. S., Katragadda, S., Pal, D., & Mitra, A. K. (2006) · Current Eye Research · doi:10.1080/02713680600693629 · Cited by 40 · see citing works

Ocular distribution of intravenously administered micafungin in rabbits

Suzuki, T., Uno, T., Chen, G., & Ohashi, Y. (2008) · Journal of Infection and Chemotherapy · doi:10.1007/s10156-008-0612-5 · Cited by 40 · see citing works

Ocular Sustained Release Nanoparticles Containing Stereoisomeric Dipeptide Prodrugs of Acyclovir

Jwala, J., Boddu, S. H. S., Shah, S. J., Sirimulla, S., Pal, D., & Mitra, A. K. (2011) · Journal of Ocular Pharmacology and Therapeutics · doi:10.1089/jop.2010.0188 · Cited by 39 · see citing works

Fibrin-Enmeshed Tobramycin Liposomes: Single Application Topical Therapy of Pseudomonas Keratitis

Frucht-Perry, J., Assil, K. K., Ziegler, E. J., Douglas, H., Brown, S. I., Schanzlin, D. J., & Weinreb, R. N. (1992) · Cornea · doi:10.1097/00003226-199209000-00006 · Cited by 39 · see citing works

Does orally administered doxycycline reach the tear film?

Smith, V. A., Khan-Lim, D., Anderson, L., Cook, S. D., & Dick, A. D. (2008) · British Journal of Ophthalmology · doi:10.1136/bjo.2007.125989 · Cited by 39 · see citing works

Looking Inside Adenovirus

Harrison, S. C. (2010) · Science · doi:10.1126/science.1194922 · Cited by 38 · see citing works

Effect of Poly(amidoamine) Dendrimers on Corneal Penetration of Puerarin

Yao, W., Sun, K., Liu, Y., Liang, N., Mu, H., Yao, C., Liang, R., & Wang, A. (2010) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.33.1371 · Cited by 38 · see citing works

Effect of Acylation on the Ocular Disposition of Acyclovir II: Corneal Permeability and Anti-HSV 1 Activity of 2′-Esters in Rabbit Epithelial Keratitis

Hughes, P. M., & Mitra, A. K. (1993) · Journal of Ocular Pharmacology and Therapeutics · doi:10.1089/jop.1993.9.299 · Cited by 38 · see citing works

Ocular drug delivery systems: An overview

Patel, A. (2013) · World Journal of Pharmacology · doi:10.5497/wjp.v2.i2.47 · Cited by 894 · see citing works

Advances in Biomaterials for Drug Delivery

Fenton, O. S., Olafson, K. N., Pillai, P. S., Mitchell, M. J., & Langer, R. (2018) · Advanced Materials · doi:10.1002/adma.201705328 · Cited by 869 · see citing works

Emerging Targets in Photopharmacology

Lerch, M. M., Hansen, M. J., van Dam, G. M., Szymański, W., & Feringa, B. L. (2016) · Angewandte Chemie International Edition · doi:10.1002/anie.201601931 · Cited by 674 · see citing works

Nanostructured lipid carriers for site-specific drug delivery

Khosa, A., Reddi, S., & Saha, R. N. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.04.055 · Cited by 622 · see citing works

An overview of clinical and commercial impact of drug delivery systems

Anselmo, A. C., & Mitragotri, S. (2014) · Journal of Controlled Release · doi:10.1016/j.jconrel.2014.03.053 · Cited by 523 · see citing works

Polymeric micelles for ocular drug delivery: From structural frameworks to recent preclinical studies

Mandal, A., Bisht, R., Rupenthal, I. D., & Mitra, A. K. (2017) · Journal of Controlled Release · doi:10.1016/j.jconrel.2017.01.012 · Cited by 481 · see citing works

A comprehensive insight on ocular pharmacokinetics

Agrahari, V., Mandal, A., Agrahari, V., Trinh, H. M., Joseph, M. A., Ray, A., Hadji, H., Mitra, R., Pal, D., & Mitra, A. K. (2016) · Drug Delivery and Translational Research · doi:10.1007/s13346-016-0339-2 · Cited by 465 · see citing works

Ocular drug delivery: present innovations and future challenges

Gote, V., Sikder, S., Sicotte, J., & Pal, D. (2019) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.119.256933 · Cited by 441 · see citing works

Ocular Drug Delivery Barriers—Role of Nanocarriers in the Treatment of Anterior Segment Ocular Diseases

Bachu, R. D., Chowdhury, P., Al-Saedi, Z. H. F., Karla, P. K., & Boddu, S. H. S. (2018) · Pharmaceutics · doi:10.3390/pharmaceutics10010028 · Cited by 425 · see citing works

Recent advances in self-assembled peptides: Implications for targeted drug delivery and vaccine engineering

Eskandari, S., Guerin, T., Tóth, I., & Stephenson, R. J. (2016) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2016.06.013 · Cited by 384 · see citing works

Drug Delivery to the Posterior Segment of the Eye: Biopharmaceutic and Pharmacokinetic Considerations

Varela‐Fernández, R., Díaz-Tomé, V., Luaces-Rodríguez, A., Conde-Penedo, A., García‐Otero, X., Álvarez, A. L., Fernández‐Ferreiro, A., & Otero-Espinar, F. J. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12030269 · Cited by 363 · see citing works

Nanotechnology based drug delivery systems for the treatment of anterior segment eye diseases

Onugwu, A. L., Nwagwu, C. S., Onugwu, S. O., Echezona, A. C., Agbo, C. P., Ihim, S. A., Emeh, P., Nnamani, P. O., Attama, A. A., & Khutoryanskiy, V. V. (2023) · Journal of Controlled Release · doi:10.1016/j.jconrel.2023.01.018 · Cited by 356 · see citing works

Lipid Nanoparticles as Carriers for Bioactive Delivery

Dhiman, N., Awasthi, R., Sharma, B., Kharkwal, H., & Kulkarni, G. T. (2021) · Frontiers in Chemistry · doi:10.3389/fchem.2021.580118 · Cited by 348 · see citing works

Self-implantable double-layered micro-drug-reservoirs for efficient and controlled ocular drug delivery

Than, A., Liu, C., Chang, H., Duong, P. K., Cheung, C. M. G., Xu, C., Wang, X., & Chen, P. (2018) · Nature Communications · doi:10.1038/s41467-018-06981-w · Cited by 347 · see citing works

Nanoparticles for drug delivery to the anterior segment of the eye

Janagam, D. R., Wu, L., & Lowe, T. L. (2017) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2017.04.001 · Cited by 343 · see citing works

Ophthalmic drug discovery: novel targets and mechanisms for retinal diseases and glaucoma

Zhang, K., Zhang, L., & Weinreb, R. N. (2012) · Nature Reviews Drug Discovery · doi:10.1038/nrd3745 · Cited by 316 · see citing works

Vascular permeability—the essentials

Claesson, L. (2015) · Upsala Journal of Medical Sciences · doi:10.3109/03009734.2015.1064501 · Cited by 304 · see citing works

Nanotechnology-based ocular drug delivery systems: recent advances and future prospects

Li, S., Chen, L., & Fu, Y. (2023) · Journal of Nanobiotechnology · doi:10.1186/s12951-023-01992-2 · Cited by 309 · see citing works

Non-Lamellar Lyotropic Liquid Crystalline Lipid Nanoparticles for the Next Generation of Nanomedicine

Zhai, J., Fong, C., Tran, N. L., & Drummond, C. J. (2019) · ACS Nano · doi:10.1021/acsnano.8b07961 · Cited by 281 · see citing works

A review on therapeutic contact lenses for ocular drug delivery

Maulvi, F. A., Soni, T. G., & Shah, D. O. (2016) · Drug Delivery · doi:10.3109/10717544.2016.1138342 · Cited by 271 · see citing works

Microneedles as the technique of drug delivery enhancement in diverse organs and tissues

Rzhevskiy, A. S., Singh, T. R. R., Donnelly, R. F., & Anissimov, Y. G. (2017) · Journal of Controlled Release · doi:10.1016/j.jconrel.2017.11.048 · Cited by 267 · see citing works

Corticosteroids in ophthalmology: drug delivery innovations, pharmacology, clinical applications, and future perspectives

Gaballa, S. A., Kompella, U. B., Elgarhy, O., Alqahtani, A. M., Pierscionek, B., Alany, R. G., & Abdelkader, H. (2021) · Drug Delivery and Translational Research · doi:10.1007/s13346-020-00843-z · Cited by 255 · see citing works

Multiple Roles of Chitosan in Mucosal Drug Delivery: An Updated Review

Mura, P., Maestrelli, F., Cirri, M., & Mennini, N. (2022) · Marine Drugs · doi:10.3390/md20050335 · Cited by 255 · see citing works

Ocular Drug Delivery: Role of Degradable Polymeric Nanocarriers for Ophthalmic Application

Tsai, C.-H., Wang, P., Lin, I., Hu, H., Liu, G., & Tseng, C. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19092830 · Cited by 241 · see citing works

Non-viral gene therapy: Gains and challenges of non-invasive administration methods

Földvári, M., Chen, D.-W., Nafissi, N., Calderon-Nieva, D., Narsineni, L., & Rafiee, A. (2015) · Journal of Controlled Release · doi:10.1016/j.jconrel.2015.12.012 · Cited by 240 · see citing works

Ocular delivery of macromolecules

Kim, Y. C., Chiang, B., Wu, X., & Prausnitz, M. R. (2014) · Journal of Controlled Release · doi:10.1016/j.jconrel.2014.06.043 · Cited by 236 · see citing works

Hydrogel Biomaterials for Application in Ocular Drug Delivery

Lynch, C. R., Kondiah, P. P. D., Choonara, Y. E., du Toit, L. C., Ally, N., & Pillay, V. (2020) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2020.00228 · Cited by 234 · see citing works

Overcoming ocular drug delivery barriers through the use of physical forces

Huang, D., Chen, Y.-S., & Rupenthal, I. D. (2017) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2017.09.008 · Cited by 230 · see citing works

Liposomes for intravitreal drug delivery: A state of the art

Bochot, A., & Fattal, E. (2012) · Journal of Controlled Release · doi:10.1016/j.jconrel.2012.01.019 · Cited by 229 · see citing works

Key advances of carboxymethyl cellulose in tissue engineering & 3D bioprinting applications

Zennifer, A., Senthilvelan, P., Sethuraman, S., & Sundaramurthi, D. (2020) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2020.117561 · Cited by 229 · see citing works

Thermosensitive Hydrogels and Advances in Their Application in Disease Therapy

Fan, R., Cheng, Y., Wang, R., Zhang, T., Zhang, H., Li, J., Song, S., & Zheng, A. (2022) · Polymers · doi:10.3390/polym14122379 · Cited by 228 · see citing works

A review on recent drug delivery systems for posterior segment of eye

Nayak, K., & Misra, M. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.08.138 · Cited by 228 · see citing works

Principles of pharmacology in the eye

Awwad, S., Mohamed Ahmed, A. H. A., Sharma, G., Heng, J. S., Khaw, P. T., Brocchini, S., & Lockwood, A. (2017) · British Journal of Pharmacology · doi:10.1111/bph.14024 · Cited by 224 · see citing works

Retinal Diseases Associated with Oxidative Stress and the Effects of a Free Radical Scavenger (Edaravone)

Masuda, T., Shimazawa, M., & Hara, H. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/9208489 · Cited by 221 · see citing works

A comprehensive review on contact lens for ophthalmic drug delivery

Xu, J., Xue, Y., Hu, G., Lin, T., Gou, J., Yin, T., He, H., Zhang, Y. X., & Tang, X. (2018) · Journal of Controlled Release · doi:10.1016/j.jconrel.2018.05.020 · Cited by 214 · see citing works

Drug Delivery Challenges and Current Progress in Nanocarrier-Based Ocular Therapeutic System

Akhter, M. H., Ahmad, I. S., Alshahrani, M. Y., Al-Harbi, A. I., Khalilullah, H., Afzal, O., Altamimi, A. S. A., Ullah, S. N. M. N., Ojha, A., & Karim, S. (2022) · Gels · doi:10.3390/gels8020082 · Cited by 212 · see citing works

Cyclodextrin‐Based Formulations: A Non‐Invasive Platform for Targeted Drug Delivery

Muankaew, C., & Loftsson, Þ. (2017) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/bcpt.12917 · Cited by 204 · see citing works

Recent Advances in Ocular Drug Delivery Systems

Kuno, N., & Fujii, S. (2011) · Polymers · doi:10.3390/polym3010193 · Cited by 202 · see citing works

Lifitegrast, a Novel Integrin Antagonist for Treatment of Dry Eye Disease

Perez, V. L., Pflugfelder, S. C., Zhang, S., Shojaei, A., & Haque, R. M. (2016) · The Ocular Surface · doi:10.1016/j.jtos.2016.01.001 · Cited by 200 · see citing works

Applications of Chitosan-Alginate-Based Nanoparticles—An Up-to-Date Review

Niculescu, A.-G., & Grumezescu, A. M. (2022) · Nanomaterials · doi:10.3390/nano12020186 · Cited by 199 · see citing works

Hyaluronic acid in ocular drug delivery

Zhang, X., Wei, D., Xu, Y., & Zhu, Q. (2021) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2021.118006 · Cited by 196 · see citing works

Topical ophthalmic lipid nanoparticle formulations (SLN, NLC) of indomethacin for delivery to the posterior segment ocular tissues

Balguri, S. P., Adelli, G. R., & Majumdar, S. (2016) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2016.10.015 · Cited by 195 · see citing works

Two-Year Intraocular Delivery of Ciliary Neurotrophic Factor by Encapsulated Cell Technology Implants in Patients with Chronic Retinal Degenerative Diseases

Kauper, K. A., McGovern, C., Sherman, S., Heatherton, P., Rapoza, R., Stabila, P. F., Dean, B., Lee, A., Borges, S., Bouchard, B., et al. (2012) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.12-9970 · Cited by 193 · see citing works

Advanced Formulation Approaches for Ocular Drug Delivery: State-Of-The-Art and Recent Patents

Souto, E. B., Dias-Ferreira, J., López-Machado, A., Ettcheto, M., Cano, A. C., Camins, A., Espina, M., García, M. L., & Sánchez‐López, E. (2019) · Pharmaceutics · doi:10.3390/pharmaceutics11090460 · Cited by 196 · see citing works

Natamycin solid lipid nanoparticles – sustained ocular delivery system of higher corneal penetration against deep fungal keratitis: preparation and optimization

Khames, A., Khaleel, M. A., El‐Badawy, M. F., & El‐Nezhawy, A. O. H. (2019) · International Journal of Nanomedicine · doi:10.2147/ijn.s190502 · Cited by 192 · see citing works

Chitosan and its Derivatives for Ocular Delivery Formulations: Recent Advances and Developments

Zamboulis, A., Nanaki, S. G., Michailidou, G., Koumentakou, I., Lazaridou, M., Ainali, N. M., Xanthopoulou, E., & Bikiaris, D. Ν. (2020) · Polymers · doi:10.3390/polym12071519 · Cited by 190 · see citing works

Novel Strategies for Anterior Segment Ocular Drug Delivery

Cholkar, K., Patel, S. P., Vadlapudi, A. D., & Mitra, A. K. (2012) · Journal of Ocular Pharmacology and Therapeutics · doi:10.1089/jop.2012.0200 · Cited by 189 · see citing works

Drug delivery to the anterior segment of the eye: A review of current and future treatment strategies

Mofidfar, M., Abdi, B., Ahadian, S., Mostafavi, E., Desai, T. A., Abbasi, F., Sun, Y., Manche, E. E., Ta, C. N., & Flowers, C. W. (2021) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2021.120924 · Cited by 187 · see citing works

Therapeutic nanoemulsions in ophthalmic drug administration: Concept in formulations and characterization techniques for ocular drug delivery

Singh, M. V., Bharadwaj, S., Lee, K. E., & Kang, S. G. (2020) · Journal of Controlled Release · doi:10.1016/j.jconrel.2020.10.025 · Cited by 184 · see citing works

Ophthalmic Drug Delivery Systems for Antibiotherapy—A Review

Dubald, M., Bourgeois, S., Andrieu, V., & Fessi, H. (2018) · Pharmaceutics · doi:10.3390/pharmaceutics10010010 · Cited by 176 · see citing works

Subretinal injection: a review on the novel route of therapeutic delivery for vitreoretinal diseases

Peng, Y., Tang, L., & Zhou, Y. (2017) · Ophthalmic Research · doi:10.1159/000479157 · Cited by 175 · see citing works

Minimally invasive microneedles for ocular drug delivery

Singh, R. R. T., Tekko, I. A., McAvoy, K., McMillan, H. L., Jones, D. S., & Donnelly, R. F. (2016) · Expert Opinion on Drug Delivery · doi:10.1080/17425247.2016.1218460 · Cited by 173 · see citing works

Dexamethasone: Insights into Pharmacological Aspects, Therapeutic Mechanisms, and Delivery Systems

Madamsetty, V. S., Mohammadinejad, R., Uzielienè, I., Nabavi, N., Dehshahri, A., García-Couce, J., Tavakol, S., Moghassemi, S., Dadashzadeh, A., Makvandi, P., et al. (2022) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.2c00026 · Cited by 173 · see citing works

Applications of poloxamers in ophthalmic pharmaceutical formulations: an overview

Almeida, H., Amaral, M. H., Lobão, P., & Lobo, J. M. S. (2013) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.2013.796360 · Cited by 172 · see citing works

Lipid nanoparticles (SLN, NLC): Overcoming the anatomical and physiological barriers of the eye – Part I – Barriers and determining factors in ocular delivery

Sánchez‐López, E., Espina, M., Doktorovová, S., Souto, E. B., & García, M. L. (2016) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2016.10.009 · Cited by 172 · see citing works

Dually functional hollow ceria nanoparticle platform for intraocular drug delivery: A push beyond the limits of static and dynamic ocular barriers toward glaucoma therapy

Luo, L., Nguyen, D. D., & Lai, J. (2020) · Biomaterials · doi:10.1016/j.biomaterials.2020.119961 · Cited by 172 · see citing works

Nanocrystals as a master key to deliver hydrophobic drugs via multiple administration routes

McGuckin, M. B., Wang, J., Ghanma, R., Qin, N., Palma, S. D., Donnelly, R. F., & Paredes, A. J. (2022) · Journal of Controlled Release · doi:10.1016/j.jconrel.2022.03.012 · Cited by 171 · see citing works

Topical Delivery of Avastin to the Posterior Segment of the Eye In Vivo Using Annexin A5‐associated Liposomes

Davis, B. M., Normando, E. M., Guo, L., Turner, L., Nizari, S., O’Shea, P., Moss, S. E., Somavarapu, S., & Cordeiro, M. F. (2014) · Small · doi:10.1002/smll.201303433 · Cited by 165 · see citing works

Eye: anatomy, physiology and barriers to drug delivery

Cholkar, K., Dasari, S. R., Pal, D., & Mitra, A. K. (2013) · Elsevier eBooks · doi:10.1533/9781908818317.1 · Cited by 163 · see citing works

Synthesis and Potential Applications of Lipid Nanoparticles in Medicine

Musielak, E., Feliczak‐Guzik, A., & Nowak, I. (2022) · Materials · doi:10.3390/ma15020682 · Cited by 161 · see citing works

In Situ Gel of Triamcinolone Acetonide-Loaded Solid Lipid Nanoparticles for Improved Topical Ocular Delivery: Tear Kinetics and Ocular Disposition Studies

Tatke, A., Dudhipala, N. R., Janga, K. Y., Balguri, S. P., Avula, B., Jablonski, M. M., & Majumdar, S. (2018) · Nanomaterials · doi:10.3390/nano9010033 · Cited by 160 · see citing works

Development and characterization of nano-fiber patch for the treatment of glaucoma

Gagandeep, Garg, T., Malik, B., Rath, G., & Goyal, A. K. (2013) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2013.11.016 · Cited by 158 · see citing works

A Comprehensive Review on Dry Eye Disease: Diagnosis, Medical Management, Recent Developments, and Future Challenges

Phadatare, S. P., Momin, M. M., Nighojkar, P., Askarkar, S., & Singh, K. K. (2015) · Advances in Pharmaceutics · doi:10.1155/2015/704946 · Cited by 157 · see citing works

Liposomes and nanotechnology in drug development: focus on ocular targets

Honda, M., Asai, Oku, Araki, Tanaka, & Ebihara (2013) · International Journal of Nanomedicine · doi:10.2147/ijn.s30725 · Cited by 157 · see citing works

Strategies for Improving Ocular Drug Bioavailability and Corneal Wound Healing with Chitosan-Based Delivery Systems

Irimia, T., Ghica, M. V., Popa, L., Anuța, V., Arsene, A., & Dinu‐Pîrvu, C. (2018) · Polymers · doi:10.3390/polym10111221 · Cited by 157 · see citing works

Solid lipid nanoparticles as promising tool for intraocular tobramycin delivery: Pharmacokinetic studies on rabbits

Chetoni, P., Burgalassi, S., Monti, D., Tampucci, S., Tullio, V. C., Cuffini, A., Muntoni, E., Spagnolo, R., Zara, G. P., & Cavalli, R. (2016) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2016.10.006 · Cited by 151 · see citing works

Cyclodextrin-Mediated Enhancement of Riboflavin Solubility and Corneal Permeability

Morrison, P. W. J., Connon, C. J., & Khutoryanskiy, V. V. (2013) · Molecular Pharmaceutics · doi:10.1021/mp3005963 · Cited by 151 · see citing works

Recent advances in microneedle-based drug delivery: Special emphasis on its use in paediatric population

Duarah, S., Sharma, M., & Wen, J. (2019) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2019.01.005 · Cited by 152 · see citing works

Intelligent wireless theranostic contact lens for electrical sensing and regulation of intraocular pressure

Yang, C. G., Wu, Q., Liu, J., Mo, J., Li, X., Yang, C., Liu, Z., Yang, J., Jiang, L., Chen, W., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-29860-x · Cited by 152 · see citing works

Sustained drug release by contact lenses for glaucoma treatment—A review

de Carvalho, I. A., Marques, C. S., Oliveira, R., Coelho, P. B., Costa, P. C., & Ferreira, D. (2015) · Journal of Controlled Release · doi:10.1016/j.jconrel.2015.01.023 · Cited by 149 · see citing works

Advanced drug delivery and targeting technologies for the ocular diseases

Barar, J., Aghanejad, A., Fathi, M., & Omidi, Y. (2016) · Bioimpacts · doi:10.15171/bi.2016.07 · Cited by 148 · see citing works

Contact Lenses: Promising Devices for Ocular Drug Delivery

Guzmán‐Aránguez, A., Colligris, B., & Pintor, J. J. (2012) · Journal of Ocular Pharmacology and Therapeutics · doi:10.1089/jop.2012.0212 · Cited by 147 · see citing works

Gene Therapy for Retinal Degenerative Diseases: Progress, Challenges, and Future Directions

Drag, S., Dotiwala, F., & Upadhyay, A. K. (2023) · Investigative Opthalmology &amp; Visual Science · doi:10.1167/iovs.64.7.39 · Cited by 145 · see citing works

Advancing the stimuli response of polymer-based drug delivery systems for ocular disease treatment

Dung, N. D., & Lai, J. (2020) · Polymer Chemistry · doi:10.1039/d0py00919a · Cited by 145 · see citing works

Polymeric Nanoparticles-Loaded Hydrogels for Biomedical Applications: A Systematic Review on In Vivo Findings

Nunes, D., Andrade, S., Ramalho, M. J., Loureiro, J. A., & Pereira, M. D. C. (2022) · Polymers · doi:10.3390/polym14051010 · Cited by 144 · see citing works

Bioadhesive chitosan-loaded liposomes: A more efficient and higher permeable ocular delivery platform for timolol maleate

Tan, G., Yu, S., Pan, H., Li, J., Liu, D., Yuan, K., Yang, X., & Pan, W. (2016) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2016.10.035 · Cited by 143 · see citing works

A Review of the Mechanism of Action of Cyclosporine A: The Role of Cyclosporine A in Dry Eye Disease and Recent Formulation Developments

Periman, L. M., Mah, F. S., & Karpecki, P. M. (2020) · Clinical ophthalmology · doi:10.2147/opth.s279051 · Cited by 149 · see citing works

Overview of Recent Advances in Nano-Based Ocular Drug Delivery

Liu, L.-C., Chen, Y., & Lu, D. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242015352 · Cited by 141 · see citing works

Cyclodextrins and topical drug delivery to the anterior and posterior segments of the eye

Loftsson, Þ., & Stefánsson, E. (2017) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2017.04.010 · Cited by 139 · see citing works

Review of Approaches for Increasing Ophthalmic Bioavailability for Eye Drop Formulations

Lanier, O. L., Manfre, M. G., Bailey, C., Liu, Z., Sparks, Z., Kulkarni, S., & Chauhan, A. (2021) · AAPS PharmSciTech · doi:10.1208/s12249-021-01977-0 · Cited by 139 · see citing works

Poloxamer 407/TPGS mixed micelles as promising carriers for cyclosporine ocular delivery

Grimaudo, M. A., Pescina, S., Padula, C., Santi, P., Concheiro, A., Alvarez-Lorenzo, C., & Nicoli, S. (2018) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.7b00939 · Cited by 138 · see citing works

Preparation and evaluation of naringenin-loaded sulfobutylether-β-cyclodextrin/chitosan nanoparticles for ocular drug delivery

Zhang, P., Liu, X., Hu, W., Bai, Y., & Zhang, L. (2016) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2016.04.115 · Cited by 138 · see citing works

Cellulosic Polymers for Enhancing Drug Bioavailability in Ocular Drug Delivery Systems

Gupta, B., Mishra, V., Gharat, S., Momin, M. M., & Omri, A. (2021) · Pharmaceuticals · doi:10.3390/ph14111201 · Cited by 138 · see citing works

Vitreous humor analysis for the detection of xenobiotics in forensic toxicology: a review

Bévalot, F., Cartiser, N., Bottinelli, C., Fanton, L., & Guitton, J. (2015) · Forensic Toxicology · doi:10.1007/s11419-015-0294-5 · Cited by 141 · see citing works

Target strategies for drug delivery bypassing ocular barriers

Suri, R., Beg, S., & Kohli, K. (2019) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2019.101389 · Cited by 134 · see citing works

Nanoemulsion Based Vehicle for Effective Ocular Delivery of Moxifloxacin Using Experimental Design and Pharmacokinetic Study in Rabbits

Shah, J., Nair, A. B., Jacob, S., Patel, R. K., Shah, H., Shehata, T. M., & Morsy, M. A. (2019) · Pharmaceutics · doi:10.3390/pharmaceutics11050230 · Cited by 132 · see citing works

Potential chitosan-coated alginate nanoparticles for ocular delivery of daptomycin

Costa, J. R., Silva, N. C., Sarmento, B. F. C. C., & Pintado, M. (2015) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-015-2344-7 · Cited by 130 · see citing works

Biopharmaceutical evaluation of epigallocatechin gallate-loaded cationic lipid nanoparticles (EGCG-LNs): In vivo , in vitro and ex vivo studies

Fangueiro, J. F., Calpena, A. C., Clares, B., Andreani, T., Egea, M. A., Veiga, F., García, M. L., Silva, A. M., & Souto, E. B. (2016) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2016.02.039 · Cited by 130 · see citing works

Contact lenses as a platform for ocular drug delivery

Bengani, L. C., Hsu, K.-H., Gause, S., & Chauhan, A. (2013) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.2013.821462 · Cited by 129 · see citing works

In vitro and ex vivo models to study drug delivery barriers in the posterior segment of the eye

Peynshaert, K., Devoldere, J., Smedt, S. C. D., & Remaut, K. (2017) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2017.09.007 · Cited by 132 · see citing works

Topical delivery of ocular therapeutics: carrier systems and physical methods

de Souza, J. G., Dias, K., Pereira, T. A., Bernardi, D. S., & Lopez, R. F. V. (2013) · Journal of Pharmacy and Pharmacology · doi:10.1111/jphp.12132 · Cited by 128 · see citing works

MOF-Based Polymeric Nanocomposite Films as Potential Materials for Drug Delivery Devices in Ocular Therapeutics

Gándara-Loe, J., Souza, B. E., Missyul, A. B., Durango-Giraldo, G., Tan, J., & Silvestre‐Albero, J. (2020) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.0c07517 · Cited by 128 · see citing works

Engineering Smart Targeting Nanovesicles and Their Combination with Hydrogels for Controlled Drug Delivery

Elkhoury, K., Koçak, P., Kang, A., Arab‐Tehrany, E., Ward, J. E., & Shin, S. R. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12090849 · Cited by 129 · see citing works

Gold nanoparticles in ophthalmology

Masse, F., Ouellette, M., Lamoureux, G., & Boisselier, É. (2018) · Medicinal Research Reviews · doi:10.1002/med.21509 · Cited by 130 · see citing works

Ion- and pH-activated novel in-situ gel system for sustained ocular drug delivery

Gupta, H., Velpandian, T., & Jain, S. (2010) · Journal of drug targeting · doi:10.3109/10611860903508788 · Cited by 127 · see citing works

Ocular drug delivery targeted by iontophoresis in the suprachoroidal space using a microneedle

Jung, J. H., Chiang, B., Grossniklaus, H. E., & Prausnitz, M. R. (2018) · Journal of Controlled Release · doi:10.1016/j.jconrel.2018.03.001 · Cited by 126 · see citing works

Nanotechnology approaches for ocular drug delivery

Kannan, R. M., Xu, Q., & Kambhampati, S. P. (2013) · Middle East African Journal of Ophthalmology · doi:10.4103/0974-9233.106384 · Cited by 125 · see citing works

Corneal Cross-linking: Intrastromal Riboflavin Concentration in Iontophoresis-Assisted Imbibition Versus Traditional and Transepithelial Techniques

Mastropasqua, L., Nubile, M., Calienno, R., Mattei, P. A., Pedrotti, E., Salgari, N., Mastropasqua, R., & Lanzini, M. (2013) · American Journal of Ophthalmology · doi:10.1016/j.ajo.2013.11.018 · Cited by 125 · see citing works

A gelatin-g-poly(N-isopropylacrylamide) biodegradable in situ gelling delivery system for the intracameral administration of pilocarpine

Lai, J., & Hsieh, A.-C. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2011.11.085 · Cited by 125 · see citing works

The potential of using biodegradable microspheres in retinal diseases and other intraocular pathologies

Herrero‐Vanrell, R., Bravo‐Osuna, I., Andrés‐Guerrero, V., Vicario‐de‐la‐Torre, M., & Molina-Martínez, I. T. (2014) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2014.04.002 · Cited by 124 · see citing works

Ophthalmic Drug Delivery system - A Review

Patel, H. A., Patel, J. K., Patel, K. N., & Patel, R. R. (2010) · Der pharmacia lettre · Cited by 22 · see citing works

A Review on Ophthalmic Drug Delivery System

Sanap, A. R. (2024) · Research Journal of Science and Technology · doi:10.52711/2349-2988.2024.00013 · Cited by 4 · see citing works

Recent Trends in Ocular Drug Delivery: A Short Review

Kumar, A., Malviya, R., & Sharma, P. K. (2011) · Cited by 35 · see citing works

Ocular drug delivery systems.

Malhotra, B. M. B., Kharkwal, H., & Pradhan, A. (2016) · CABI eBooks · doi:10.1079/9781780644479.0160 · Cited by 3 · see citing works

Ocular drug delivery: present innovations and future challenges

Gote, V., Sikder, S., Sicotte, J., & Pal, D. (2019) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.119.256933 · Cited by 441 · see citing works