Cited by 128MRI in cancer diagnosisBreast Lesions and CarcinomasBreast Cancer Treatment Studies

Role of Magnetic Resonance Imaging in Detection of Pathologic Complete Remission in Breast Cancer Patients Treated With Neoadjuvant Chemotherapy: A Meta-analysis

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Gu, Yan-Lin, Pan, Si-Meng, Ren, Jie, Yang, Zhi-Xue, Jiang, Guo-Qin·2017·Clinical Breast Cancer

Abstract

Pathologic complete remission after neoadjuvant chemotherapy has a role in guiding the management of breast cancer. The present meta-analysis examined the accuracy of contrast-enhanced magnetic resonance imaging (CE-MRI) and diffusion-weighted magnetic resonance imaging (DW-MRI) in detecting the response to neoadjuvant chemotherapy and compared CE-MRI with ultrasonography, mammography, and positron emission tomography/computed tomography (PET/CT). Medical subject heading terms and related keywords were searched to generate a compilation of eligible studies. The pooled sensitivity, specificity, diagnostic odds ratio, area under summary receiver operating characteristic curve (AUC), and Youden index (Q* index) were used to estimate the diagnostic efficacy of CE-MRI, DW-MRI, ultrasonography, mammography, and PET/CT. A total of 54 studies of CE-MRI and 8 studies of DW-MRI were included. The overall AUC and the Q* index values for CE-MRI and DW-MRI were 0.88 and 0.94 and 0.80 and 0.85, respectively. According to the summary receiver operating characteristic curves, CE-MRI resulted in a higher AUC value and Q* index compared with ultrasonography and mammography but had values similar to those of DW-MRI and PET/CT. CE-MRI accurately assessed pathologic complete remission in specificity, and PET/CT and DW-MRI accurately assessed pathologic complete remission in sensitivity. The present meta-analysis indicates that CE-MRI has high specificity and DW-MRI has high sensitivity in predicting pathologic complete remission after neoadjuvant chemotherapy. CE-MRI is more accurate than ultrasonography or mammography. Additionally, PET/CT is valuable for predicting pathologic complete remission. CE-MRI, combined with PET/CT or DW-MRI, might allow for a more precise assessment of pathologic complete remission.

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Crossref · 10.1016/j.clbc.2016.12.010

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Authors
Gu, Y.-L., Pan, S.-M., Ren, J., Yang, Z.-X., & Jiang, G.-Q.
Affiliations
Second Affiliated Hospital of Soochow University (CN)
Corresponding author
Jiang, Guo-Qin
Venue
Clinical Breast Cancer
Publisher
Elsevier BV
Published
2017-07
Volume
17
Issue
4
Pages
245-255
ISSN
1526-8209 (ISSN-L)
OpenAlex
W2572933046
Cited by
128
References
85
Citations by year
2026: 4 · 2025: 12 · 2024: 12 · 2023: 19 · 2022: 19 · 2021: 15 · 2020: 10 · 2019: 20 · 2018: 12 · 2017: 5
FWCI
1.95
Type
journal article
Language
en
Open access
Locations
  • Clinical Breast Cancer (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
Funders
  • Science, Education and Health Foundation of Soochow City (KJXW2014011)
  • Soochow Science and Technology Project (SYS201631)
  • The Second Affiliated Hospital of Soochow University (XKQ2015008)
Topics
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › MRI in cancer diagnosis
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Breast Lesions and Carcinomas
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Breast Cancer Treatment Studies
Keywords
breast cancer, neoadjuvant chemotherapy, contrast-enhanced MRI, diffusion-weighted imaging, PET/CT, ultrasonography, mammography, treatment response assessment, diagnostic accuracy, sensitivity and specificity
MeSH terms
Breast Neoplasms, Female, Humans, Magnetic Resonance Imaging, Remission Induction, Chemotherapy, Adjuvant, Neoadjuvant Therapy

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