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Cited by 274Alcohol Consumption and Health EffectsDrug-Induced Hepatotoxicity and ProtectionPharmacogenetics and Drug Metabolism

The DOI matches its Crossref record; 288 of the 293 references it cites were found in a registry or an index.

Metabolism of Alcohol

Lieber, Charles S.·2005·Clinics in Liver Disease
DOI 10.1016/j.cld.2004.10.005
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Abstract

Most tissues of the body contain enzymes capable of ethanol oxidation or nonoxidative metabolism, but significant activity occurs only in the liver and, to a lesser extent, in the stomach. Hence, medical consequences are predominant in these organs. In the liver, ethanol oxidation generates an excess of reducing equivalents, primarily as NADH, causing hepatotoxicity. An additional system, containing cytochromes P-450 inducible by chronic alcohol feeding, was demonstrated in liver microsomes and found to be a major cause of hepatotoxicity.

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Crossref · 10.1016/j.cld.2004.10.005

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Citations

Cites

Research works printed but not linked: 15

  1. Chedid, 1991, Prognostic factors in alcoholic liver disease, Am J Gastroenterol, 82, 210
  2. Brighenti, 1970, Effetto della somministrazione di alcool etilico su alcune attivita enzimatiche del fegato di ratto, Boll Soc It Biol Sper, 46, 1
  3. Iseri, 1964, The ultrastructure of ethanol-induced fatty liver, Fed Proc, 23, 579
  4. Takahashi, 1993, Induction of P450E1 in human liver by ethanol is due to a corresponding increase in encoding mRNA, Hepatology, 17, 236
  5. Tsutsumi, 1988, Intralobular distribution of ethanol-inducible cytochrome P-450IIE1 in liver, Hepatolgoy, 8, 1237A
  6. Leo, 1993, Differential depletion of carotenoids and tocopherol in liver diseases, Hepatology, 17, 977
  7. Kaikaus, 1990, Induction of liver fatty acid binding protein (l-FABP) and peroxisomal fatty acid β-oxidation by peroxisome proliferators (PP) is dependent on cytochrome p-450 activity, Hepatology, 12, 899A
  8. Harada, 1979, Studies on liver alcohol and acetaldehyde dehydrogenase variants in Japanese, Hoppe Seylers Z Physiol Chem, 360, 278
  9. Ijiri, 1974, Studies of the relationship between the concentrations of blood acetaldehyde and urinary catecholamine and the symptoms after drinking alcohol, Jpn J Stud Alcohol, 9, 35
  10. Lieber, 1992, Dietary dilinoleoylphosphatidyl-choline (DLPC) is incorporated into liver phospholipids, protects against alcoholic cirrhosis, enhances collagenase activity and prevents acetaldehyde-induced collagen accumulation in cultured lipocytes, Hepatology, 16, 87A
  11. Fox, 1983, Polyene phosphatidylcholine: pharmacokinetics after oral administrationa review, 65
  12. Klein, 1967, Blutalkohol und Fluguntuchtigkeit. Versuch einer Erarbeitung von Richtwerten für die allgemeine Luftfahrt, Int Z Angew Physiol, 24, 254
  13. Pateron, 1990, Influence de l'alcool et de la cirrhose sur la présence de Helicobacter pylori dans la muqueuse gastrique, Gastroenterol Clin Biol, 14, 555
  14. Kessova, 1998, Inducibility of cytochromes P4502E1 & P4501A1 in rat pancreas, Alcohol Clin Exp Res, 22, 501, 10.1111/j.1530-0277.1998.tb03679.x · DOI
  15. Raucy, 1991, Induction of P450IIE1 in the obese rat, Mol Pharmacol, 39, 275

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Metadata

Authors
Lieber, C. S.
Affiliations
James J. Peters VA Medical Center (US)
Corresponding author
Lieber, Charles S.
Venue
Clinics in Liver Disease
Publisher
Elsevier BV
Published
2005-02
Volume
9
Issue
1
Pages
1-35
ISSN
1089-3261 (ISSN-L)
DOI
10.1016/j.cld.2004.10.005
OpenAlex
W2045003374
Cited by
274
References
293
Citations by year
2026: 4 · 2025: 16 · 2024: 9 · 2023: 13 · 2022: 13 · 2021: 11 · 2020: 10 · 2019: 7 · 2018: 14 · 2017: 10 · 2016: 8 · 2015: 17 · 2014: 18 · 2013: 11 · 2012: 15
FWCI
2.06
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Clinics in Liver Disease (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Drug-Induced Hepatotoxicity and Protection
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
Keywords
alcohol metabolism, ethanol oxidation, liver, hepatotoxicity, NADH, cytochrome P450, chronic alcohol feeding, liver microsomes, stomach
MeSH terms
Alcohol Oxidoreductases, Ethanol, Alcoholism, Animals, Chronic Disease, Disease Models, Animal, Female, Humans, Liver Diseases, Alcoholic, Male, Microsomes, Liver, Mitochondria, Liver, Prognosis, Severity of Illness Index, Oxidative Stress, Disease Progression, Risk Assessment

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