The DOI matches its Crossref record; 288 of the 293 references it cites were found in a registry or an index.
Metabolism of Alcohol
Abstract
Most tissues of the body contain enzymes capable of ethanol oxidation or nonoxidative metabolism, but significant activity occurs only in the liver and, to a lesser extent, in the stomach. Hence, medical consequences are predominant in these organs. In the liver, ethanol oxidation generates an excess of reducing equivalents, primarily as NADH, causing hepatotoxicity. An additional system, containing cytochromes P-450 inducible by chronic alcohol feeding, was demonstrated in liver microsomes and found to be a major cause of hepatotoxicity.
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“The oxidative pathway is the major pathway for alcohol metabolism and is composed of two steps.”
From Pathophysiological Aspects of Alcohol Metabolism in the Liver (2021) · cites this paper as [26]
In the citing paper
“In the liver, alcohol is metabolized by oxidative and non-oxidative pathways (Figure 1) [26,27].”
From Pathophysiological Aspects of Alcohol Metabolism in the Liver (2021) · cites this paper as [26]
Citations
Cites
Free radicals in biology and medicine
Gutteridge, J. M. C. (1991) · General Pharmacology The Vascular System · doi:10.1016/0306-3623(91)90478-o · Cited by 17,178
Nonalcoholic Fatty Liver Disease
Angulo, P. (2002) · New England Journal of Medicine · doi:10.1056/nejmra011775 · Cited by 5,228
Free Radicals in Biology and Medicine
Land, E. J. (1990) · International Journal of Radiation Biology · doi:10.1080/09553009014552071 · Cited by 4,871
(1994) · New England Journal of Medicine · doi:10.1056/nejm199404143301501 · Cited by 4,737
Effects of a combination of beta carotene and vitamin A on lung cancer and cardiovascular disease
Omenn, G. S., Goodman, G. E., Thornquist, M. D., Balmes, J., Cullen, M. R., Glass, A., Keogh, J. P., Meyskens, F. L., Valanis, B., Williams, J. H., et al. (1996) · New England Journal of Medicine · doi:10.1056/nejm199605023341802 · Cited by 3,638
PHARMACOLOGICAL IMPLICATIONS OF MICROSOMAL ENZYME INDUCTION
Conney, A. H. (1967) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)07146-7 · Cited by 2,942
Frezza, M., di Padova, C., Pozzato, G., Terpin, M., Baraona, E., & Lieber, C. S. (1990) · New England Journal of Medicine · doi:10.1056/nejm199001113220205 · Cited by 1,328
Self-citationOmenn, G. S., Goodman, G. E., Thornquist, M. D., Balmes, J., Cullen, M. R., Glass, A., Keogh, J. P., Meyskens, F. L., Valanis, B., Williams, J. H., et al. (1996) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/88.21.1550 · Cited by 1,255
Albanes, D., Heinonen, O. P., Taylor, P. R., Virtamo, J., Edwards, B. K., Rautalahti, M. T., Hartman, A. M., Palmgren, J., Freedman, L. S., Haapakoski, J., et al. (1996) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/88.21.1560 · Cited by 902
Cytochrome P-4502E1: its physiological and pathological role
Lieber, C. S. (1997) · Physiological Reviews · doi:10.1152/physrev.1997.77.2.517 · Cited by 889
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Research works printed but not linked: 15
- Chedid, 1991, Prognostic factors in alcoholic liver disease, Am J Gastroenterol, 82, 210
- Brighenti, 1970, Effetto della somministrazione di alcool etilico su alcune attivita enzimatiche del fegato di ratto, Boll Soc It Biol Sper, 46, 1
- Iseri, 1964, The ultrastructure of ethanol-induced fatty liver, Fed Proc, 23, 579
- Takahashi, 1993, Induction of P450E1 in human liver by ethanol is due to a corresponding increase in encoding mRNA, Hepatology, 17, 236
- Tsutsumi, 1988, Intralobular distribution of ethanol-inducible cytochrome P-450IIE1 in liver, Hepatolgoy, 8, 1237A
- Leo, 1993, Differential depletion of carotenoids and tocopherol in liver diseases, Hepatology, 17, 977
- Kaikaus, 1990, Induction of liver fatty acid binding protein (l-FABP) and peroxisomal fatty acid β-oxidation by peroxisome proliferators (PP) is dependent on cytochrome p-450 activity, Hepatology, 12, 899A
- Harada, 1979, Studies on liver alcohol and acetaldehyde dehydrogenase variants in Japanese, Hoppe Seylers Z Physiol Chem, 360, 278
- Ijiri, 1974, Studies of the relationship between the concentrations of blood acetaldehyde and urinary catecholamine and the symptoms after drinking alcohol, Jpn J Stud Alcohol, 9, 35
- Lieber, 1992, Dietary dilinoleoylphosphatidyl-choline (DLPC) is incorporated into liver phospholipids, protects against alcoholic cirrhosis, enhances collagenase activity and prevents acetaldehyde-induced collagen accumulation in cultured lipocytes, Hepatology, 16, 87A
- Fox, 1983, Polyene phosphatidylcholine: pharmacokinetics after oral administrationa review, 65
- Klein, 1967, Blutalkohol und Fluguntuchtigkeit. Versuch einer Erarbeitung von Richtwerten für die allgemeine Luftfahrt, Int Z Angew Physiol, 24, 254
- Pateron, 1990, Influence de l'alcool et de la cirrhose sur la présence de Helicobacter pylori dans la muqueuse gastrique, Gastroenterol Clin Biol, 14, 555
- Kessova, 1998, Inducibility of cytochromes P4502E1 & P4501A1 in rat pancreas, Alcohol Clin Exp Res, 22, 501, 10.1111/j.1530-0277.1998.tb03679.x · DOI
- Raucy, 1991, Induction of P450IIE1 in the obese rat, Mol Pharmacol, 39, 275
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King, W. C., Chen, J.-Y., Mitchell, J. E., Kalarchian, M. A., Steffen, K. J., Engel, S. G., Courcoulas, A. P., Pories, W. J., & Yanovski, S. Z. (2012) · JAMA · doi:10.1001/jama.2012.6147 · Cited by 509
Voltage-dependent anion channel (VDAC) as mitochondrial governator—Thinking outside the box
Lemasters, J. J., & Holmuhamedov, E. (2005) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2005.10.006 · Cited by 442
Pathophysiological Aspects of Alcohol Metabolism in the Liver
Hyun, J., Han, J., Lee, C., Yoon, M., & Jung, Y. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22115717 · Cited by 324
Cytochrome P450 2E1 contributes to ethanol-induced fatty liver in mice
Lu, Y., Zhuge, J., Wang, X., Bai, J., & Cederbaum, A. I. (2008) · Hepatology · doi:10.1002/hep.22222 · Cited by 310
Alcoholic liver disease: New insights in pathogenesis lead to new treatments
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Metadata
- Authors
- Lieber, C. S.
- Affiliations
- James J. Peters VA Medical Center (US)
- Corresponding author
- Lieber, Charles S.
- Venue
- Clinics in Liver Disease
- Publisher
- Elsevier BV
- Published
- 2005-02
- Volume
- 9
- Issue
- 1
- Pages
- 1-35
- ISSN
- 1089-3261 (ISSN-L)
- OpenAlex
- W2045003374
- Cited by
- 274
- References
- 293
- Citations by year
- 2026: 4 · 2025: 16 · 2024: 9 · 2023: 13 · 2022: 13 · 2021: 11 · 2020: 10 · 2019: 7 · 2018: 14 · 2017: 10 · 2016: 8 · 2015: 17 · 2014: 18 · 2013: 11 · 2012: 15
- FWCI
- 2.06
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinics in Liver Disease (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Drug-Induced Hepatotoxicity and Protection
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
- Keywords
- alcohol metabolism, ethanol oxidation, liver, hepatotoxicity, NADH, cytochrome P450, chronic alcohol feeding, liver microsomes, stomach
- MeSH terms
- Alcohol Oxidoreductases, Ethanol, Alcoholism, Animals, Chronic Disease, Disease Models, Animal, Female, Humans, Liver Diseases, Alcoholic, Male, Microsomes, Liver, Mitochondria, Liver, Prognosis, Severity of Illness Index, Oxidative Stress, Disease Progression, Risk Assessment
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