The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.
Can routine automated urinalysis reduce culture requests?
Abstract
Objectives There are a substantial number of unnecessary urine culture requests. We aimed to investigate whether urine dipstick and microscopy results could accurately rule out urinary tract infection (UTI) without urine culture. Design and methods The study included a total of 32,998 patients (11,928 men and 21,070 women, mean age: 39 ± 32 years) with a preliminary diagnosis of UTI and both urinalysis and urinary culture were requested. All urine cultures were retrospectively reviewed; association of culture positivity with a positive urinalysis result for leukocyte esterase (LE) and nitrite in chemical analysis and pyuria (WBC) and bacteriuria in microscopy was determined. Diagnostic performance of urinalysis parameters for detection of UTI was evaluated. Results In total, 758 (2.3%) patients were positive by urine culture. Out of these culture positive samples, ratios of positive dipstick results for LE and nitrite were 71.0% (n=538) and 17.7% (n=134), respectively. The positive microscopy results for WBC and bacteria were 68.2% (n=517) and 78.8% (n=597), respectively. Negative predictive values for LE, nitrite, bacteriuria and WBC were very close to 100%. Conclusions Most of the samples have no or insignificant bacterial growth. Urine dipstick and microscopy can accurately rule out UTI. Automated urinalysis is a practicable and faster screening test which may prevent unnecessary culture requests for majority of patients.
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“Negative dipstick test results with positive urine culture were observed in 267 (2.7%) cases.”
From Performance of the dipstick screening test as a predictor of negative urine culture (2017) · cites this paper as [30]
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The urine dipstick test useful to rule out infections. A meta-analysis of the accuracy
Devillé, W. L., Yzermans, J. C., van Duijn, N. P., Bezemer, P. D., van der Windt, D. A., & Bouter, L. M. (2004) · BMC Urology · doi:10.1186/1471-2490-4-4 · Cited by 519
European Urinalysis Guidelines
Kouri, T., Fogazzi, G., Gant, V., Hallander, H., Hofmann, W., & Guder, W. G. (2000) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.1080/00365513.2000.12056993 · Cited by 384
Williams, G. J., Macaskill, P., Chan, S. F., Turner, R. M., Hodson, E., & Craig, J. C. (2010) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(10)70031-1 · Cited by 198
Whiting, P., Westwood, M., Watt, I., Cooper, J., & Kleijnen, J. (2005) · BMC Pediatrics · doi:10.1186/1471-2431-5-4 · Cited by 164
Thyroglobulin in serum as an indicator of iodine status during pregnancy
Eltom, A. (2000) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.1080/00365510050184985 · Cited by 125
Little, P. S., Turner, S., Rumsby, K., Warner, G., Moore, M. V., Lowes, J. A., Smith, H. E., Hawke, C. I., & Mullee, M. (2006) · PubMed · Cited by 123
Mori, R., Yonemoto, N., Fitzgerald, A., Tullus, K., Verrier‐Jones, K., & Lakhanpaul, M. (2010) · Acta Paediatrica · doi:10.1111/j.1651-2227.2009.01644.x · Cited by 99
Ditchburn, R., & Ditchburn, J. (1990) · Europe PMC (PubMed Central) · Cited by 75
Little, P. S., Rumsby, K., Jones, R., Warner, G., Moore, M. V., Lowes, J. A., Smith, H. E., Hawke, C. I., Leydon, G., & Mullee, M. (2010) · British Journal of General Practice · doi:10.3399/bjgp10x514747 · Cited by 71
Can urine dipstick testing for urinary tract infection at point of care reduce laboratory workload?
Patel, H., Livsey, S. A., Swann, R. A., & Bukhari, S. (2005) · Journal of Clinical Pathology · doi:10.1136/jcp.2004.025429 · Cited by 69
Cited by
Diagnosis and treatment of urinary tract infections across age groups
Chu, C. M., & Lowder, J. L. (2018) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2017.12.231 · Cited by 337
Urinary Tract Infection and Asymptomatic Bacteriuria in Older Adults
Cortes-Penfield, N. W., Trautner, B. W., & Jump, R. L. P. (2017) · Infectious Disease Clinics of North America · doi:10.1016/j.idc.2017.07.002 · Cited by 211
The Five Ds of Outpatient Antibiotic Stewardship for Urinary Tract Infections
Goebel, M. C., Trautner, B. W., & Grigoryan, L. (2021) · Clinical Microbiology Reviews · doi:10.1128/cmr.00003-20 · Cited by 138
Claeys, K. C., Trautner, B. W., Leekha, S., Coffey, K., Crnich, C. J., Diekema, D. J., Fakih, M. G., Goetz, M. B., Gupta, K., Jones, M., et al. (2021) · Clinical Infectious Diseases · doi:10.1093/cid/ciab987 · Cited by 86
Rosa, R. D., Grosso, S., Lorenzi, G., Bruschetta, G., & Camporese, A. (2018) · Clinica Chimica Acta · doi:10.1016/j.cca.2018.05.047 · Cited by 79
Metadata
- Authors
- Kayalp, D., Dogan, K., Ceylan, G., Senes, M., & Yucel, D.
- Affiliations
- Ministry of Health (TR)
- Venue
- Clinical Biochemistry
- Publisher
- Elsevier BV
- Published
- 2013-09
- Volume
- 46
- Issue
- 13-14
- Pages
- 1285-1289
- ISSN
- 0009-9120 (ISSN-L)
- OpenAlex
- W1993538649
- Cited by
- 65
- References
- 24
- Citations by year
- 2025: 5 · 2024: 3 · 2023: 7 · 2022: 4 · 2021: 9 · 2020: 7 · 2019: 3 · 2018: 7 · 2017: 7 · 2016: 7 · 2015: 2 · 2014: 4
- FWCI
- 3.15
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- Locations
- Clinical Biochemistry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Urology › Urinary Tract Infections Management
- Health Sciences › Health Professions › Medical Laboratory Technology › Clinical Laboratory Practices and Quality Control
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pediatric Urology and Nephrology Studies
- Keywords
- urinary tract infection, automated urine analysis, urine dipstick, urine microscopy, urine culture, leukocyte esterase, nitrite, pyuria, bacteriuria, diagnostic accuracy, negative predictive value, screening test
- MeSH terms
- Adolescent, Adult, Aged, Aged, 80 and over, Bacteriuria, Child, Child, Preschool, Female, Humans, Infant, Infant, Newborn, Male, Middle Aged, Reagent Strips, Urinary Tract Infections, Urine, Urinalysis, Cell Culture Techniques
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- The paper
- Kayalp, D., Dogan, K., Ceylan, G., Senes, M., & Yucel, D. (2013). Can routine automated urinalysis reduce culture requests? Clinical Biochemistry. https://doi.org/10.1016/j.clinbiochem.2013.06.015
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
