The multiple functions and mechanisms of osteopontin
Abstract
Osteopontin (OPN) is a highly phosphorylated glycophosphoprotein having acidic characteristics and rich in aspartic acid. OPN, a multifunctional protein, has important functions on cardiovascular diseases, cancer, diabetes and kidney stone diseases and in the process of inflammation, biomineralization, cell viability and wound healing. Osteopontin acts on organisms by playing a key role in secretion levels of interleukin-10 (IL-10), interleukin-12 (IL-12), interleukin-3 (IL-3), interferon-γ (IFN-γ), integrin αvB3, nuclear factor kappa B (NF-kB), macrophage and T cells, regulating the osteoclast function and affecting CD44 receptors. The aim of the present review is to address majority of different functions of OPN protein which are known, suspected or suggested through the data obtained about this protein yet.
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Osteopontin encoded by SPP1 shows decreased expression in cEDS patients' cells.
“Osteopontin encoded by SPP1, which shows a decreased expression in patients’ cells, is involved in several physiological processes related to inflammation, biomineralization, cell viability, and wound healing [56,57].”
From Cellular and Molecular Mechanisms in the Pathogenesis of Classical, Vascular, and Hypermobile Ehlers‒Danlos Syndromes (2019) · cites this paper as [57]
Osteopontin is a multifunctional cytokine with key roles in inflammation, cell viability, and tissue repair, and functions as a bone matrix protein mediating osteoclast adhesion.
“Osteopontin is a multifunctional cytokine with key roles in inflammation, cell viability, and tissue repair, which also functions as a bone matrix protein that mediates osteoclast adhesion [196, 197].”
From Intrinsically disordered proteins play diverse roles in cell signaling (2022) · cites this paper as [196]
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Dimitrow, P. P., Jawień, M., & Gackowski, A. (2011) · PubMed · Cited by 19 · see citing works
Dynamic footprint of sequestration in the molecular fluctuations of osteopontin
Lenton, S., Seydel, T., Nylander, T., Holt, C., Haertlein, M., Teixeira, S. C. M., & Zaccaı̈, G. (2015) · Journal of The Royal Society Interface · doi:10.1098/rsif.2015.0506 · Cited by 18 · see citing works
Crucial role of the cryptic epitope SLAYGLR within osteopontin in renal crystal formation of mice
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High-Phosphorus Diet Induces Osteopontin Expression of Renal Tubules in Rats
Matsuzaki, H., Katsumata, S.-I., Uehara, M., et al. (2007) · Journal of Clinical Biochemistry and Nutrition · doi:10.3164/jcbn.2007025 · Cited by 15 · see citing works
Hashiguchi, Y., Tsuda, H., Bandera, C. A., et al. (2006) · Medical Oncology · doi:10.1385/mo:23:2:205 · Cited by 15 · see citing works
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Linkages of nuclear architecture to biological and pathological control of gene expression
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Johnson, E. C. B., Dammer, E. B., Duong, D. M., Ping, L., Zhou, M., Yin, L., Higginbotham, L. A., Guajardo, A., White, B., Troncoso, J. C., et al. (2020) · Nature Medicine · doi:10.1038/s41591-020-0815-6 · Cited by 1,001 · see citing works
Intrinsically disordered proteins play diverse roles in cell signaling
Bondos, S. E., Dunker, A. K., & Uversky, V. N. (2022) · Cell Communication and Signaling · doi:10.1186/s12964-022-00821-7 · Cited by 222 · see citing works
The Development of Molecular Biology of Osteoporosis
Gao, Y., Patil, S., & Jia, J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22158182 · Cited by 116 · see citing works
Chiarelli, N., Ritelli, M., Zoppi, N., & Colombi, M. (2019) · Genes · doi:10.3390/genes10080609 · Cited by 82 · see citing works
Increasing the biomolecular relevance of cell culture practice
Ghebosu, R. E., Hui, L., & Wolfram, J. (2025) · Journal of Biomedical Science · doi:10.1186/s12929-024-01095-6 · Cited by 11 · see citing works
- Authors
- Icer, M. A., & Gezmen-Karadag, M.
- Venue
- Clinical Biochemistry
- Publisher
- Elsevier BV
- Published
- 2018-09
- Volume
- 59
- Pages
- 17-24
- ISSN
- 0009-9120 (ISSN-L)
- OpenAlex
- W2841068772
- Cited by
- 606
- References
- 101
- Citations by year
- 2026: 50 · 2025: 90 · 2024: 98 · 2023: 106 · 2022: 94 · 2021: 76 · 2020: 48 · 2019: 38 · 2018: 6
- FWCI
- 6.97
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinical Biochemistry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Rheumatology › Bone and Dental Protein Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › S100 Proteins and Annexins
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Connective Tissue Growth Factor Research
- Keywords
- osteopontin, multifunctional proteins, cardiovascular disease, cancer, diabetes mellitus, kidney stones, inflammation, biomineralization, wound healing, cytokine regulation, integrin αvβ3, NF-κB, macrophages, T cells, osteoclast function, CD44 receptor
- MeSH terms
- Animals, Calcinosis, Humans, Joint Diseases, Macrophages, T-Lymphocytes, Tumor Necrosis Factor-alpha, Vascular Diseases, Signal Transduction, Biomarkers, Fractures, Bone, Osteopontin, Plaque, Atherosclerotic
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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