Red face revisited: Endogenous dermatitis in the form of atopic dermatitis and seborrheic dermatitis
Abstract
Atopic dermatitis and seborrheic dermatitis are multifactorial dermatitides that are known collectively as endogenous dermatitis. Both conditions can affect the face, but they have clinical, epidemiological, and physiopathological peculiarities that distinguish them from each other. These two diseases are very common all around the world. Atopic dermatitis is associated with xerosis and increased susceptibility to irritants and proteins; patients with this condition have a tendency to develop asthma, allergic rhinitis, and systemic manifestations that are mediated by immunoglobulin E. Seborrheic dermatitis is a moderate chronic dermatitis that is restricted to regions with a high production of sebum and areas that have cutaneous folds. There are many studies about pathophysiology related to the immunology and genetics of atopic dermatitis, but little is known about the genetic and immunological markers of seborrheic dermatitis.
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Immunological defects may play a role in SD.
“These observations suggest that immunological defects may play a role in SD.”
From Seborrheic Dermatitis and Dandruff: A Comprehensive Review (2015) · cites this paper as [15]
Most cases of SD in HIV patients are diagnosed with CD4+ T lymphocyte counts between 200 and 500/mm3, and decreased CD4+ counts are often associated with worse SD.
“Most cases of SD in HIV patients are diagnosed with CD4+ T lymphocyte counts between 200 and 500/mm3 [3,14,15], and decreased CD4+ counts are often associated with worse SD.”
From Seborrheic Dermatitis and Dandruff: A Comprehensive Review (2015) · cites this paper as [15]
The main complication of SD is secondary bacterial infection, which increases redness and exudate and local irritation.
“The main complication is secondary bacterial infection, which increases the redness and exudate and local irritation [3,15].”
From Seborrheic Dermatitis and Dandruff: A Comprehensive Review (2015) · cites this paper as [15]
Cites
Filaggrin in atopic dermatitis
O'Regan, G. M., Sandilands, A., McLean, W. H. I., & Irvine, A. D. (2008) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2008.08.002 · Cited by 350 · see citing works
Interleukin-10 Downregulates Anti-Microbial Peptide Expression in Atopic Dermatitis
Howell, M. D., Novak, N., Bieber, T., Pastore, S., Girolomoni, G., Boguniewicz, M., Streib, J., Wong, C., Gallo, R. L., & Leung, D. Y. M. (2005) · Journal of Investigative Dermatology · doi:10.1111/j.0022-202x.2005.23776.x · Cited by 193 · see citing works
Faergemann, J., Bergbrant, I.-M., Dohsé, M., Scott, A., & Westgate, G. (2001) · British Journal of Dermatology · doi:10.1046/j.1365-2133.2001.04082.x · Cited by 173 · see citing works
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Seborrheic Dermatitis and Dandruff: A Comprehensive Review
(2015) · Journal of Clinical and Investigative Dermatology · doi:10.13188/2373-1044.1000019 · Cited by 398 · see citing works
- Authors
- Ramos-e-Silva, M., Sampaio, A. L., & Carneiro, S.
- Affiliations
- Universidade Federal do Rio de Janeiro (BR)
- ORCID
- Carneiro, Sueli
- Venue
- Clinics in Dermatology
- Publisher
- Elsevier BV
- Published
- 2014-01
- Volume
- 32
- Issue
- 1
- Pages
- 109-115
- ISSN
- 0738-081X (ISSN-L)
- OpenAlex
- W1966170089
- Cited by
- 16
- References
- 3
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 2 · 2023: 2 · 2022: 2 · 2021: 1 · 2019: 2 · 2016: 1 · 2015: 3
- FWCI
- 0.22
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinics in Dermatology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Health Sciences › Medicine › Epidemiology › Nail Diseases and Treatments
- Health Sciences › Medicine › Dermatology › Contact Dermatitis and Allergies
- Keywords
- atopic dermatitis, seborrheic dermatitis, facial dermatitis, dry skin, immunoglobulin E, asthma, allergic rhinitis, sebum, genetic markers, immunological markers, pathophysiology
- MeSH terms
- Dermatitis, Atopic, Facial Dermatoses, Humans, Dermatitis, Seborrheic
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