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Cited by 173Nail Diseases and TreatmentsDermatology and Skin DiseasesHair Growth and Disorders

Seborrhoeic dermatitis and Pityrosporum ( Malassezia ) folliculitis: characterization of inflammatory cells and mediators in the skin by immunohistochemistry

Faergemann, J., Bergbrant, I-M., Dohsé, M., Scott, A., Westgate, G.·2001·British Journal of Dermatology
DOI 10.1046/j.1365-2133.2001.04082.x
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Abstract

BACKGROUND: The fact that Pityrosporum ovale plays a part in seborrhoeic dermatitis is well established but the mechanism of this relationship has not been established. OBJECTIVES: To compare the number and type of inflammatory cells and mediators in skin biopsies from normal and lesional skin from the trunk and scalp in patients with seborrhoeic dermatitis, Pityrosporum (Malassezia) folliculitis and in normal skin from healthy controls. METHODS: The skin biopsies were stained using the labelled Streptavidin-biotin METHOD: The following markers were studied: CD4, CD8, CD68, HLA-DR, NK1, CD16, C1q, C3c, IgG, CD54 (ICAM-1), interleukin (IL) -1alpha, IL-1beta, IL-2, IL-4, IL-6, IL-10, IL-12, tumour necrosis factor-alpha and interferon-gamma. RESULTS: HLA-DR+ cells were seen in the highest number, and were higher in lesional skin compared with normal skin from both patients and healthy volunteers. ICAM-1 expression was also increased in lesional skin. C1q and the interleukins showed an increased cellular and intercellular staining in patients compared with healthy controls and the intercellular staining was often more intense in lesions compared with non-lesional skin. Staining was often more intense when Malassezia (Pityrosporum ovale) yeast cells were present. CONCLUSIONS: An increase in NK1+ and CD16+ cells in combination with complement activation indicates that an irritant non-immunogenic stimulation of the immune system is important. The result with the interleukins showed both an increase in the production of inflammatory interleukins as well as in the regulatory interleukins for both TH1 and TH2 cells. Similarities to the immune response described for Candida albicans infections indicate the role of Malassezia in the skin response in seborrhoeic dermatitis and Pityrosporum folliculitis.

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  • These metabolites induce keratinocytes to produce pro-inflammatory cytokines such as IL-1α, IL-6, IL-8 and TNF-α, thus prolonging the inflammatory response.

    “In addition, these metabolites induce keratinocytes to produce pro-inflammatory cytokines such as IL-1α, IL-6, IL-8 and TNF-α, thus prolonging the inflammatory response [39,54].”

    From Seborrheic Dermatitis and Dandruff: A Comprehensive Review (2015) · cites this paper as [54]

  • The strong inflammatory reaction provoked by yeast metabolites includes infiltration of Natural Killer (NK) cells and macrophages, with concurrent local activation of complement and increased local production of inflammatory cytokines such as IL-1α, IL-1β, IL-6 and TNF-α in affected skin areas.

    “The strong inflammatory reaction provoked by these metabolites includes infiltration of Natural Killer (NK) cells and macrophages, with concurrent local activation of complement and an increased local production of inflammatory cytokines, such as IL-1α, IL-1β, IL-6 and TNF-α in affected skin areas [54].”

    From Seborrheic Dermatitis and Dandruff: A Comprehensive Review (2015) · cites this paper as [54]

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Authors
Faergemann, J., Bergbrant, I.-M., Dohsé, M., Scott, A., & Westgate, G.
Affiliations
  • Sahlgrenska University Hospital (SE)
  • Unilever (United Kingdom) (GB)
Corresponding author
Faergemann, J.
ORCID
Westgate, G.
Venue
British Journal of Dermatology
Publisher
Oxford University Press (OUP)
Published
2001-03
Volume
144
Issue
3
Pages
549-556
ISSN
  • 0007-0963 (ISSN-L)
  • 1365-2133
DOI
10.1046/j.1365-2133.2001.04082.x
OpenAlex
W2060407666
Cited by
173
References
20
Citations by year
2026: 5 · 2025: 9 · 2024: 7 · 2023: 6 · 2022: 5 · 2021: 5 · 2020: 11 · 2019: 10 · 2018: 1 · 2017: 4 · 2016: 1 · 2015: 6 · 2014: 6 · 2013: 11 · 2012: 8
FWCI
6.61
Type
journal article
Language
en
Open access
closed
Licence
doi.wiley.com/10.1002/tdm_license_1.1 (tdm, 5297 d)
Locations
  • British Journal of Dermatology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Epidemiology › Nail Diseases and Treatments
  • Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
  • Health Sciences › Medicine › Urology › Hair Growth and Disorders
Keywords
seborrheic dermatitis, pityrosporum folliculitis, Malassezia folliculitis, inflammatory cells, cytokines, interleukins, HLA-DR, ICAM-1, complement activation, C1q, CD16+ cells, Th1/Th2 balance, scalp skin, lesional skin
MeSH terms
Adult, Complement Activation, Dermatomycoses, Female, Folliculitis, HLA-DR Antigens, Humans, Immunoenzyme Techniques, Interleukins, Malassezia, Male, Middle Aged, Dermatitis, Seborrheic, Skin, Immunophenotyping, Inflammation Mediators

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