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Mycosis fungoides: A great imitator
Abstract
Mycosis fungoides (MF), the most common cutaneous T-cell lymphoma, typically presents in its early stage as inflammatory erythematous patches or plaques, with epidermotropism as the histopathologic hallmark of the disease. Over the past 30 years, numerous atypical types of MF, which deviate from the classic Alibert-Bazin presentation of the disease, have been described. These variants can simulate a wide variety of benign inflammatory skin disorders either clinically, both clinically and histopathologically, or mainly histopathologically. We have summarized the many faces of the disease, which set MF as a "great imitator," with special focus on the differential diagnosis and its benign mimickers.
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“Mycosis fungoides (MF), the most common cutaneous T-cell lymphoma (CTCL), is notoriously difficult to diagnose in its early stages due to its profound clinical and histological overlap with benign inflammatory dermatoses (BIDs).”
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Metadata
- Authors
- Hodak, E., & Amitay-Laish, I.
- Affiliations
- Tel Aviv University (IL)
- Corresponding author
- Hodak, Emmilia
- ORCID
- Hodak, Emmilia
- Venue
- Clinics in Dermatology
- Publisher
- Elsevier BV
- Published
- 2019-05
- Volume
- 37
- Issue
- 3
- Pages
- 255-267
- ISSN
- 0738-081X (ISSN-L)
- OpenAlex
- W2909334221
- Cited by
- 163
- References
- 142
- Citations by year
- 2026: 19 · 2025: 19 · 2024: 28 · 2023: 45 · 2022: 15 · 2021: 24 · 2020: 10 · 2019: 3
- FWCI
- 13.04
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinics in Dermatology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Dermatology › Cutaneous lymphoproliferative disorders research
- Health Sciences › Medicine › Dermatology › Medicine and Dermatology Studies History
- Health Sciences › Medicine › Pathology and Forensic Medicine › Lymphoma Diagnosis and Treatment
- Keywords
- mycosis fungoides, cutaneous T-cell lymphoma, atypical variant, epidermotropism, differential diagnosis, inflammatory skin diseases
- MeSH terms
- Diagnosis, Differential, Female, Humans, Male, Mycosis Fungoides, Skin
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