The DOI matches its Crossref record; 119 of the 122 references it cites were found in a registry or an index.
Psychological aspects of multiple sclerosis
Abstract
A significant incidence and prevalence of psychological disorders in multiple sclerosis (MS) has been reported. Their underlying mechanisms and the extent to which they are reactive to psychosocial factors or symptoms of the pathological process itself, remain unclear. Depression is the predominant psychological disturbance with lifetime prevalence around 50% and annual prevalence of 20%. Depression is commoner during relapses, may exacerbate fatigue and cognitive dysfunction and no firm evidence exists of its induction by interferon; instead, treating depression improves adherence to disease-modifying drugs. Anxiety is also frequent, occurs in newly diagnosed patients, and its co-morbidity with depression has been suggested to increase the rate of suicidal ideation. The relationship between stress and MS is an attractive issue because some studies pointed to an association between stressful life-events and MS onset/relapses; however, the evidence supporting this hypothesis is not conclusive so far. Other psychiatric illnesses, as bipolar affective disorder, pathological laughing and crying or psychosis occur less frequently in MS. Therapeutic strategies include psychotherapy, cognitive behavioural therapy, strengthen of coping, and specific medications. The "art" of the MS team in providing the best individualized care is emphasized, aiming to reduce the burden of the disease and improve the patients' quality of life.
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“Anxiety can aggravate disease symptoms, such as fatigue and cognitive complaints, and has a negative influence on one’s work and social life.4”
From EMDR treatment for anxiety in MS patients: A pilot study (2020) · cites this paper as [4]
Citations
Cites
Psychological stress and the coping process
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Depression and multiple sclerosis
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Research works printed but not linked: 2
- Thomas, 2007, Psychological interventions for multiple sclerosis (review), vol. 1
- Davidson, 1969, Schizophrenia-like psychoses associated with organic disorders of the central nervous system: a review of the literature, Br J Psychiatry, 4, 113
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Jones, K. H., Ford, D. V., Jones, P. A., John, A., Middleton, R. M., Lockhart-Jones, H., Osborne, L. A., & Noble, J. G. (2012) · PLoS ONE · doi:10.1371/journal.pone.0041910 · Cited by 190
Neuropsychiatric Symptoms of Multiple Sclerosis: State of the Art
Silveira, C., Guedes, R., Maia, D., Curral, R., & Coelho, R. C. (2019) · Psychiatry Investigation · doi:10.30773/pi.2019.0106 · Cited by 181
Neuropsychiatric syndromes of multiple sclerosis
Murphy, R., O’Donoghue, S., Counihan, T. J., McDonald, C., Calabresi, P. A., Ahmed, M. A., Kaplin, A. I., & Hallahan, B. P. (2017) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2016-315367 · Cited by 182
Neuroinflammation drives anxiety and depression in relapsing-remitting multiple sclerosis
Rossi, S., Studer, V., Motta, C., Polidoro, S., Perugini, J., Macchiarulo, G., Giovannetti, A. M., Gutierrez, L. P., Calò, A., Colonna, I., et al. (2017) · Neurology · doi:10.1212/wnl.0000000000004411 · Cited by 175
Social-psychological adjustment to multiple sclerosis
Brooks, N. A., & Matson, R. R. (1982) · Social Science & Medicine · doi:10.1016/0277-9536(82)90262-3 · Cited by 166
Metadata
- Authors
- Sá, M. J.
- Venue
- Clinical Neurology and Neurosurgery
- Publisher
- Elsevier BV
- Published
- 2008-11
- Volume
- 110
- Issue
- 9
- Pages
- 868-877
- ISSN
- 0303-8467 (ISSN-L)
- OpenAlex
- W2075214874
- Cited by
- 155
- References
- 122
- Citations by year
- 2026: 5 · 2025: 5 · 2024: 3 · 2023: 9 · 2022: 8 · 2021: 7 · 2020: 4 · 2019: 8 · 2018: 11 · 2017: 11 · 2016: 12 · 2015: 9 · 2014: 10 · 2013: 10 · 2012: 10
- FWCI
- 0.65
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinical Neurology and Neurosurgery (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
- Health Sciences › Medicine › Oncology › Cancer survivorship and care
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Keywords
- multiple sclerosis, depression, anxiety, psychological comorbidity, relapse, fatigue, cognitive impairment, stress, life events, bipolar disorder, psychosomatic symptoms, psychosis, suicidal ideation, psychosocial factors, coping, cognitive behavioral therapy, psychotherapy, quality of life, individualized care
- MeSH terms
- Anxiety, Depression, Humans, Multiple Sclerosis, Psychotic Disorders, Stress, Psychological, Mood Disorders
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