Adaptive reorganization of cortical networks in Alzheimer’s disease
Open accessAbstract
Objective The impact of neuronal cell loss associated with Alzheimer's disease (AD) on the network organization of the brain is poorly understood. Here we investigated whether modifications in resting-state functional connectivity (FC) are associated with cognitive function of AD patients. Methods High-density electroencephalograms (EEGs) were obtained from patients with early stages of AD and elderly healthy controls. Cortical oscillations were reconstructed with an adaptive spatial filter. Maps of imaginary coherence (IC) between brain areas were compared between groups and correlated with cognitive performance. Results Parietal and medial temporal lobes of AD patients showed a disruption of alpha band FC to the rest of the brain. However, an adaptive extension of the language network to the right hemisphere could be observed in AD patients and was correlated with better verbal fluency. A shift of FC from alpha frequencies to theta frequencies could be observed in a memory network and was associated with better verbal memory performance. Conclusions Not only dysfunctional but also adaptive network reorganization occurs in early AD. Significance The network mechanisms for preserved cognitive functioning may inform novel treatment strategies for AD in the future.
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During AD development there exists a reorganization of neuronal network connectivity, not only a generalized reduction, but an adaptive response due to pathological changes.
“The finding correlates with evidence that during AD development there exists a reorganization of neuronal network connectivity, not only resembling a generalized reduction, but an adaptive response due to pathological changes (Dubovik et al., 2013).”
From Early stage alterations in white matter and decreased functional interhemispheric hippocampal connectivity in the 3xTg mouse model of Alzheimer’s disease. (2019) · cites this paper as Dubovik et al., 2013
Cites
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“In other studies theta was related to attentional control processes involving primarily frontal brain regions (Asada et al., 1999).”
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Intrinsic Coupling Modes: Multiscale Interactions in Ongoing Brain Activity
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- Authors
- Dubovik, S., Bouzerda-Wahlen, A., Nahum, L., Gold, G., Schnider, A., & Guggisberg, A. G.
- Affiliations
- University of Geneva (CH)
- Venue
- Clinical Neurophysiology
- Publisher
- Elsevier BV
- Published
- 2013-01
- Volume
- 124
- Issue
- 1
- Pages
- 35-43
- ISSN
- 1388-2457 (ISSN-L)
- OpenAlex
- W2060164021
- Cited by
- 34
- References
- 4
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 1 · 2022: 1 · 2021: 6 · 2020: 3 · 2019: 2 · 2018: 3 · 2017: 1 · 2016: 1 · 2015: 4 · 2014: 5 · 2013: 3
- FWCI
- 1.96
- Type
- journal article
- Language
- en
- Open access
- Locations
- Clinical Neurophysiology (publishedVersion)
- PubMed (publishedVersion)
- Archive ouverte UNIGE (University of Geneva) (submittedVersion, cc-by)
- Funders
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (129679)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- Alzheimer's disease, resting-state functional connectivity, adaptive spatial filtering, imaginary coherence, alpha-band connectivity, language network, verbal fluency, verbal memory, parietal lobe, medial temporal lobe, early Alzheimer's disease, cognitive performance
- MeSH terms
- Adaptation, Physiological, Aged, Aged, 80 and over, Alzheimer Disease, Cerebral Cortex, Electric Stimulation, Electroencephalography, Female, Frontal Lobe, Hippocampus, Humans, Language, Language Tests, Male, Memory, Nerve Net, Neuropsychological Tests, Psychomotor Performance, Verbal Behavior, Stroke
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