Cited by 471Neural dynamics and brain functionFunctional Brain Connectivity StudiesNonlinear Dynamics and Pattern Formation

Intrinsic Coupling Modes: Multiscale Interactions in Ongoing Brain Activity

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Engel, Andreas K., Gerloff, Christian, Hilgetag, Claus C., Nolte, Guido·2013·Neuron

Abstract

Intrinsic coupling constitutes a key feature of ongoing brain activity, which exhibits rich spatiotemporal patterning and contains information that influences cognitive processing. We discuss evidence for two distinct types of intrinsic coupling modes which seem to reflect the operation of different coupling mechanisms. One type arises from phase coupling of band-limited oscillatory signals, whereas the other results from coupled aperiodic fluctuations of signal envelopes. The two coupling modes differ in their dynamics, their origins, and their putative functions and with respect to their alteration in neuropsychiatric disorders. We propose that the concept of intrinsic coupling modes can provide a unifying framework for capturing the dynamics of intrinsically generated neuronal interactions at multiple spatial and temporal scales.

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Crossref · 10.1016/j.neuron.2013.09.038

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Authors
Engel, A. K., Gerloff, C., Hilgetag, C. C., & Nolte, G.
Affiliations
  • University Medical Center Hamburg-Eppendorf (DE)
  • Boston University (US)
Corresponding author
Engel, Andreas K.
Venue
Neuron
Publisher
Elsevier BV
Published
2013-11
Volume
80
Issue
4
Pages
867-886
ISSN
0896-6273 (ISSN-L)
OpenAlex
W1967064349
Cited by
471
References
193
Citations by year
2026: 22 · 2025: 38 · 2024: 39 · 2023: 45 · 2022: 35 · 2021: 35 · 2020: 43 · 2019: 44 · 2018: 27 · 2017: 40 · 2016: 46 · 2015: 34 · 2014: 23
FWCI
2.93
Type
journal article
Language
en
Open access
Locations
  • Neuron (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
  • Physical Sciences › Computer Science › Computer Networks and Communications › Nonlinear Dynamics and Pattern Formation
Keywords
ongoing brain activity, phase coupling, neuropsychiatric disorders, spatiotemporal brain dynamics
MeSH terms
Brain, Cognition, Computer Simulation, Electroencephalography, Humans, Magnetic Resonance Imaging, Models, Neurological, Electrophysiological Phenomena

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