Quantitative electroencephalography as a marker of cognitive fluctuations in dementia with Lewy bodies and an aid to differential diagnosis
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OBJECTIVE: We investigated for quantitative EEG (QEEG) differences between Alzheimer's disease (AD), dementia with Lewy bodies (DLB) and Parkinson's disease dementia (PDD) patients and healthy controls, and for QEEG signatures of cognitive fluctuations (CFs) in DLB. METHODS: We analysed eyes-closed, resting state EEGs from 18 AD, 17 DLB and 17 PDD patients with mild dementia, and 21 age-matched controls. Measures included spectral power, dominant frequency (DF), frequency prevalence (FP), and temporal DF variability (DFV), within defined EEG frequency bands and cortical regions. RESULTS: DLB and PDD patients showed a leftward shift in the power spectrum and DF. AD patients showed greater DFV compared to the other groups. In DLB patients only, greater DFV and EEG slowing were correlated with CFs, measured by the clinician assessment of fluctuations (CAF) scale. The diagnostic accuracy of the QEEG measures was 94% (90.4-97.9%), with 92.26% (80.4-100%) sensitivity and 83.3% (73.6-93%) specificity. CONCLUSION: Although greater DFV was only shown in the AD group, within the DLB group a positive DFV - CF correlation was found. QEEG measures could classify DLB and AD patients with high sensitivity and specificity. SIGNIFICANCE: The findings add to an expanding literature suggesting that EEG is a viable diagnostic and symptom biomarker in dementia, particularly DLB.
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QEEG features provide a valuable variable in distinguishing various etiological dementias, such as DLB, PDD, and AD.
“Several studies[23-26] have suggested that QEEG features provide a valuable variable in distinguishing various etiological dementias, such as dementia with Lewy bodies (DLB), PD with dementia (PDD), and Alzheimer’s disease (AD).”
From QEEG Signatures are Associated with Nonmotor Dysfunctions in Parkinson's Disease and Atypical Parkinsonism: An Integrative Analysis (2023) · cites this paper as [23]
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- Authors
- Stylianou, M., Murphy, N., Peraza, L. R., Graziadio, S., Cromarty, R., Killen, A., O' Brien, J. T., Thomas, A. J., LeBeau, F. E. N., & Taylor, J.-P.
- Affiliations
- Newcastle University (GB)
- Newcastle upon Tyne Hospitals NHS Foundation Trust (GB)
- Corresponding author
- Stylianou, Myrto
- ORCID
- Venue
- Clinical Neurophysiology
- Publisher
- Elsevier BV
- Published
- 2018-06
- Volume
- 129
- Issue
- 6
- Pages
- 1209-1220
- ISSN
- 1388-2457 (ISSN-L)
- PMC
- PMC5954167
- OpenAlex
- W2795901230
- Cited by
- 79
- References
- 62
- Citations by year
- 2026: 7 · 2025: 9 · 2024: 7 · 2023: 7 · 2022: 11 · 2021: 8 · 2020: 19 · 2019: 9 · 2018: 2
- FWCI
- 7.36
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Clinical Neurophysiology (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Apollo (University of Cambridge) (submittedVersion, cc-by)
- Newcastle University ePrints (Newcastle Univesity) (cc-by-nc-nd)
- Funders
- Alzheimer’s Society
- NIHR Newcastle Biomedical Research Centre
- Newcastle Hospitals NHS Charity
- Northumberland, Tyne and Wear NHS Foundation Trust
- Wellcome Trust (BH120812, BH120878)
- Alzheimer’s Research UK
- NIHR MedTech In Vitro Diagnostic Co-operatives scheme (MIC-2016-014)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Life Sciences › Neuroscience › Cognitive Neuroscience › EEG and Brain-Computer Interfaces
- Keywords
- quantitative EEG, dementia with Lewy bodies, Parkinson's disease dementia, Alzheimer's disease, cognitive fluctuations, differential diagnosis, EEG slowing, spectral power, diagnostic accuracy
- MeSH terms
- Aged, Aged, 80 and over, Alzheimer Disease, Brain, Cognition, Diagnosis, Differential, Electroencephalography, Female, Humans, Male, Parkinson Disease, Sensitivity and Specificity, Lewy Body Disease
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