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Cited by 51Curcumin's Biomedical ApplicationsDialysis and Renal Disease ManagementSaffron Plant Research Studies

Evaluation of Curcumin's effect on inflammation in hemodialysis patients

Samadian, Fariba, Dalili, Nooshin, Poor -reza Gholi, Fatemeh, Fattah, Mahtab, Malih, Narges, Nafar, Mohsen, Firoozan, Ahmad, Ahmadpoor, Pedram +2 more·2017·Clinical Nutrition ESPEN
DOI 10.1016/j.clnesp.2017.09.006
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Abstract

Objective Despite advances in prevention of inflammatory milieu with different anti-inflammatory modalities in hemodialysis patients the rate of inflammatory markers in this population are still high. Inflammation is considered as a major player in uremia associated with morbidity and mortality in hemodialysis patients. The aim of this study was to evaluate the turmeric s effects on reduction of inflammatory markers in hemodialysis patients.Methods Hemodialysis patients over 18 years were recruited after fulfilling the inclusion criteria. Seventy-one hemodialysis patients were randomized into two groups: the trial group (n = 35) and the controls (n = 36); a randomization numeric table was used for allocation sequence. Trial group received turmeric and control group received placebo for 12 weeks. Biochemical determinations included levels of serum albumin (Alb), potassium (K), blood urea nitrogen (BUN), serum creatinine (Cr), IL-6 level, TNF-α, and liver function tests and hs-CRP at the start and end of the study were measured.Results Although there was a significant reduction in hs-CRP level, IL-6 level and TNF-α level in turmeric group (p = 0.002, p = 0.001, p = 0.001), there was no statistical difference between intervention and control groups. Albumin level was significantly increased in turmeric group (p = 0.001) and no meaningful changes were seen in potassium or liver function tests neither within nor between groups.Conclusion Programmed ingestion of turmeric has no adverse effects and reduces plasma level of hs-CRP, IL-6 and TNF-α accompanying with increases albumin levels in hemodialysis patients. Turmeric can be considered as an effective anti-inflammatory supplement in hemodialysis patients.

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  • Curcumin suppresses inflammation parameters IL-6 and TNF-α in clinical trials of chronic kidney diseases.

    “Several clinical trials of various models of chronic kidney diseases have been carried out using curcumin which resulted in the suppression of inflammation parameters at the level of IL-6 and TNF-α (Samadian et al. 2017).”

    From Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging (2023) · cites this paper as Samadian et al. 2017

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Authors
Samadian, F., Dalili, N., Poor -reza Gholi, F., Fattah, M., Malih, N., Nafar, M., Firoozan, A., Ahmadpoor, P., Samavat, S., & Ziaie, S.
Affiliations
  • Hospital Labbafinejad (IR)
  • Shahid Beheshti University (IR)
Corresponding author
Ziaie, Shadi
ORCID
Venue
Clinical Nutrition ESPEN
Publisher
Elsevier BV
Published
2017-12
Volume
22
Pages
19-23
ISSN
2405-4577 (ISSN-L)
DOI
10.1016/j.clnesp.2017.09.006
OpenAlex
W2763161106
Cited by
51
References
16
Citations by year
2026: 2 · 2025: 6 · 2024: 7 · 2023: 5 · 2022: 11 · 2021: 10 · 2020: 6 · 2019: 4
FWCI
1.05
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Clinical Nutrition ESPEN (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Curcumin's Biomedical Applications
  • Health Sciences › Medicine › Nephrology › Dialysis and Renal Disease Management
  • Health Sciences › Medicine › Oncology › Saffron Plant Research Studies
Keywords
curcumin, turmeric, hemodialysis patients, inflammation, inflammatory markers, high-sensitivity C-reactive protein, interleukin-6, TNF-α, serum albumin, uremia, anti-inflammatory supplementation
MeSH terms
Adult, Aged, C-Reactive Protein, Curcumin, Double-Blind Method, Female, Renal Dialysis, Humans, Inflammation, Male, Middle Aged, Serum Albumin, Tumor Necrosis Factor-alpha, Biomarkers, Interleukin-6, Dietary Supplements, Curcuma

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