Effect of eicosapentaenoic acid on prevention of lean body mass depletion in patients with exacerbation of chronic obstructive pulmonary disease: A prospective randomized controlled trial
Abstract
Background & aims Systemic inflammation plays an important role in the pathogenesis of chronic obstructive pulmonary disease (COPD), resulting in depletion of lean body mass (LBM) and muscle mass. Both frequent exacerbation of COPD and low LBM are associated with poor prognosis. This study aimed to evaluate whether supplementation of eicosapentaenoic acid (EPA) prevents depletion of LBM and muscle mass in hospitalized patients with exacerbation of COPD. Methods This was a prospective randomized controlled trial, conducted between November 2014 and October 2017. Fifty patients were randomly assigned to receive 1 g/day of EPA-enriched oral nutrition supplementation (ONS) (EPA group) or EPA-free ONS of similar energy (control group) during hospitalization. The LBM index (LBMI) and the skeletal muscle mass index (SMI) were measured using a bioelectrical impedance analyzer at the time of admission and at the time of discharge. Patients underwent pulmonary rehabilitation and wore a pedometer to measure step counts and physical activity. Results Forty-five patients that completed the experiment were analyzed. Baseline characteristics were similar between the EPA (n = 24) and control groups (n = 21). There were no significant differences in energy intake, step counts, physical activity, or length of hospitalization between the two groups. Although the plasma levels of EPA significantly increased only in the EPA group, we found an insignificant increase in LBMI and SMI in the EPA grou…
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A prospective study in Japan in 50 patients with exacerbation of COPD found no significant increase in lean body mass index or skeletal muscle mass index in the EPA group compared with the control group at discharge (LBM index: +0.35 vs. +0.19 kg/m2, p=0.60; SMM index: +0.2 vs. -0.3 kg/m2, p=0.17).
“At discharge (after 12e13 days of supplementation in both groups), there was a nonsignificant increase in lean body mass index and skeletal muscle mass index in the EPA group compared with the CG (lean body mass index: þ0.35 vs. þ0.19kg/m 2 , p ¼ 0.60, and skeletal muscle mass index: þ0.2 vs. À0.3kg/m 2 , p ¼ 0.17, respectively).”
From ESPEN guideline on nutritional support for polymorbid medical inpatients (2023) · cites this paper as [105]
We cannot recommend the use of other disease-specific nutritional supplementation in polymorbid medical inpatients.
“We cannot recommend the use of other disease-specific nutritional supplementation in polymorbid medical inpatients.”
From ESPEN guideline on nutritional support for polymorbid medical inpatients (2023) · cites this paper as [105]
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ESPEN guideline on nutritional support for polymorbid medical inpatients
Wunderle, C., Gomes, F., Schuetz, P., Stumpf, F., Austin, P., Ballesteros-Pomar, M. D., Cederholm, T., Fletcher, J., Laviano, A., Norman, K., et al. (2023) · Clinical Nutrition · doi:10.1016/j.clnu.2023.06.023 · Cited by 105 · see citing works
“One of such prospective studies with negative fi ndings was conducted in Japan in 50 patients with exacerbation of COPD [105] ( Level of evidence 1 þ ).”
Schneider, J., Ye, D., Hill, A. M., & Whitehorn, A. S. (2020) · Scientometrics · doi:10.1007/s11192-020-03631-1 · Cited by 88 · see citing works
- Authors
- Ogasawara, T., Marui, S., Miura, E., Sugiura, M., Matsuyama, W., Aoshima, Y., Kasamatsu, N., Ogiku, M., & Ikematsu, Y.
- Affiliations
- Hamamatsu Medical Center (JP)
- Corresponding author
- Ogasawara, Takashi
- ORCID
- Ogasawara, Takashi
- Venue
- Clinical Nutrition ESPEN
- Publisher
- Elsevier BV
- Published
- 2018-12
- Volume
- 28
- Pages
- 67-73
- ISSN
- 2405-4577 (ISSN-L)
- OpenAlex
- W2896406853
- Cited by
- 32
- References
- 0
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 8 · 2023: 5 · 2022: 3 · 2021: 3 · 2020: 5 · 2019: 2
- FWCI
- 1.72
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinical Nutrition ESPEN (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Chronic Obstructive Pulmonary Disease (COPD) Research
- Health Sciences › Nursing › Nutrition and Dietetics › Clinical Nutrition and Gastroenterology
- Keywords
- eicosapentaenoic acid, COPD exacerbations, lean body mass, muscle mass, systemic inflammation, skeletal muscle index, length of hospital stay, hospitalized patients
- MeSH terms
- Aged, Body Composition, Cachexia, Female, Humans, Male, Nutritional Status, Prospective Studies, Eicosapentaenoic Acid, Treatment Outcome, Dietary Supplements, Pulmonary Disease, Chronic Obstructive
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