Glutamine in the ICU: Who needs supply?
Abstract
Many ICU patients are glutamine depleted and have low glutamine plasma concentrations. Beneficial effects by glutamine supply could be proven in these patients. In some medical conditions, especially those with acute right heart failure, elevated glutamine plasma concentrations are present and glutamine supply may be disastrous and a toxic burden. It will be prudent to reassess the use of glutamine in ICU especially in conditions with unresolved shock or right heart failure.
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In the REDOXS trial, some patients exhibited high levels of plasma GLN.
“In the REDOXS trial (209), some patients exhibited high levels of plasmaGLN (210, 211).”
From ESPEN guideline on clinical nutrition in the intensive care unit. (2019) · cites this paper as [210]
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ESPEN guideline on clinical nutrition in the intensive care unit.
Singer, P., Blaser, A. R., Berger, M. M., Alhazzani, W., Calder, P. C., Casaer, M. P., Hiesmayr, M., Mayer, K., Montejo, J. C., Pichard, C., et al. (2019) · Clinical Nutrition · doi:10.1016/j.clnu.2018.08.037 · Cited by 2,904 · see citing works
- Authors
- Gottschalk, A., Wempe, C., & Goeters, C.
- Affiliations
- University of Münster (DE)
- Corresponding author
- Goeters, Christiane
- ORCID
- Gottschalk, Antje
- Venue
- Clinical Nutrition
- Publisher
- Elsevier BV
- Published
- 2013-08
- Volume
- 32
- Issue
- 4
- Pages
- 668-669
- ISSN
- 0261-5614 (ISSN-L)
- OpenAlex
- W2126379924
- Cited by
- 9
- References
- 0
- Citations by year
- 2020: 1 · 2019: 1 · 2018: 2 · 2016: 2 · 2015: 2 · 2014: 1
- FWCI
- 0.89
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinical Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Clinical Nutrition and Gastroenterology
- Health Sciences › Medicine › Epidemiology › Sepsis Diagnosis and Treatment
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Keywords
- glutamine supplementation, critically ill patients, glutamine deprivation, plasma glutamine, right heart failure, shock, intensive care nutrition
- MeSH terms
- Glutamine, Heart Failure, Humans, Intensive Care Units
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