CoChat
Sign Up
Cited by 98Clinical Nutrition and GastroenterologyCentral Venous Catheters and HemodialysisDialysis and Renal Disease Management

The DOI matches its Crossref record.

Five-year survival and causes of death in patients on home parenteral nutrition for severe chronic and benign intestinal failure

Open access
Joly, Francisca, Baxter, Janet, Staun, Michael, Kelly, Darlene G., Hwa, Yi Lisa, Corcos, Olivier, De Francesco, Antonella, Agostini, Federica, Klek, Stanislaw, Santarpia, Lidia, Contaldo, Franco, Jonker, Cora, Wanten, Geert, Chicharro, Luisa, Burgos, Rosa, Van Gossum, Andre, Cuerda, Cristina, Virgili, Nuria, Pironi, Loris·2018·Clinical Nutrition
DOI 10.1016/j.clnu.2017.06.016
Open this paper in CoChat — free accountOpen PDF

Abstract

Background & aim Home parenteral nutrition (HPN) is the primary treatment for chronic intestinal failure (IF). Intestinal transplantation (ITx) is indicated when there is an increased risk of death due to HPN complications or to the underlying disease. Age, pathophysiologic conditions and underlying disease are known predictors of HPN dependency and overall survival. Although the cause of death on HPN is mostly related to underlying disease in these patients, the relationship between mortality and duration of HPN use remains unclear. The purpose of the present study is to describe factors associated with survival and HPN dependency as well as causes of death in adult patients requiring HPN for chronic intestinal failure during the first 5 years of treatment with HPN. Methods A multicenter international (European and USA) questionnaire-based retrospective follow-up of a cohort of 472 IF patients who started HPN was conducted between June and December 2000. Study endpoint was either end of 5-year follow-up, weaned-off HPN, ITx, or death on HPN. Data were analyzed for HPN dependence and overall survival using Kaplan-Meier models and log rank tests. Results The overall survival probability was 88%, 74% and 64% at 1, 3 and 5 years respectively. Survival was inversely related to age (p < .001) and higher in patients with Crohn's disease or chronic idiopathic pseudo-obstruction. A total of 169 (36.5%) patients were weaned-off HPN mainly (80%) within the first year and most frequently in patients with fistulae. Five of the 14 patients who underwent ITx died. By the end of the study, 104 (23%) of patients died on HPN; 65% of deaths occurred within the first 2.5 years of HPN. Conclusions Younger ages at HPN initiation and underlying pathologies are significantly predictive of survival on HPN. Risk of death is greatest during the first 2 years of HPN.

Overview

Integrity signals

Registry

Crossref · 10.1016/j.clnu.2017.06.016

Cites

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

No references could be resolved yet.

Research works printed but not linked: 27

  1. Pironi, 2015, ESPEN endorsed recommendations. Definition and classification of intestinal failure in adults, Clin Nutr, 34, 171, 10.1016/j.clnu.2014.08.017 · DOI
  2. Pironi, 2016, ESPEN guidelines on chronic intestinal failure in adults, Clin Nutr, 35, 247, 10.1016/j.clnu.2016.01.020 · DOI
  3. Jeejeebhoy, 2008, Treatment of intestinal failure: transplantation or home parenteral nutrition?, Gastroenterology, 135, 303, 10.1053/j.gastro.2008.06.012 · DOI
  4. Buchman, 2006, Parenteral nutrition-associated liver disease and the role for isolated intestine and intestine/liver transplantation, Hepatology, 43, 9, 10.1002/hep.20997 · DOI
  5. Kelly, 2006, Intestinal failure-associated liver disease: what do we know today?, Gastroenterology, 130, S70, 10.1053/j.gastro.2005.10.066 · DOI
  6. Carroll, 2016, Management and complications of short bowel syndrome: an updated review, Curr Gastroenterol Rep, 18, 40, 10.1007/s11894-016-0511-3 · DOI
  7. Howard, 2003, Management of complications in patients receiving home parenteral nutrition, Gastroenterology, 124, 1651, 10.1016/S0016-5085(03)00326-3 · DOI
  8. Messing, 1999, Long-term survival and parenteral nutrition dependence in adult patients with the short bowel syndrome, Gastroenterology, 117, 1043, 10.1016/S0016-5085(99)70388-4 · DOI
  9. Amiot, 2013, Determinants of home parenteral nutrition dependence and survival of 268 patients with non-malignant short bowel syndrome, Clin Nutr, 32, 368, 10.1016/j.clnu.2012.08.007 · DOI
  10. Freeman, 2008, Liver and intestine transplantation in the United States, 1997-2006, Am J Transplant, 8, 958, 10.1111/j.1600-6143.2008.02174.x · DOI
  11. Pironi, 2011, Long-term follow-up of patients on home parenteral nutrition in Europe: implications for intestinal transplantation, Gut, 60, 17, 10.1136/gut.2010.223255 · DOI
  12. Grant, 2015, Intestinal transplant registry report: global activity and trends, Am J Transplant, 15, 210, 10.1111/ajt.12979 · DOI
  13. Lloyd, 2006, Survival and dependence on home parenteral nutrition: experience over a 25-year period in a UK referral centre, Aliment Pharm Ther, 24, 1231, 10.1111/j.1365-2036.2006.03106.x · DOI
  14. Colomb, 2007, J Pediatr Gastroenterol Nutr, 44, 347, 10.1097/MPG.0b013e31802c6971 · DOI
  15. Howard, 2006, Home parenteral nutrition: survival, cost, and quality of life, Gastroenterology, 130, S52, 10.1053/j.gastro.2005.09.065 · DOI
  16. Howard, 1995, Current use and clinical outcome of home parenteral and enteral nutrition therapies in the United States, Gastroenterology, 109, 355, 10.1016/0016-5085(95)90321-6 · DOI
  17. Scolapio, 1999, Survival of home parenteral nutrition-treated patients: 20 years of experience at the Mayo Clinic, Mayo Clin Proc, 74, 217, 10.4065/74.3.217 · DOI
  18. Layec, 2013, Increased intestinal absorption by segmental reversal of the small bowel in adult patients with short-bowel syndrome: a case-control study, Am J Clin Nutr, 97, 100, 10.3945/ajcn.112.042606 · DOI
  19. Panis, 1997, Segmental reversal of the small bowel as an alternative to intestinal transplantation in patients with short bowel syndrome, Ann Surg, 225, 401, 10.1097/00000658-199704000-00009 · DOI
  20. Thompson, 2008, Intestinal lengthening for short bowel syndrome, Adv Surg, 42, 49, 10.1016/j.yasu.2008.03.009 · DOI
  21. Elriz, 2011, Crohn's disease patients with chronic intestinal failure receiving long-term parenteral nutrition: a cross-national adult study, Aliment Pharmacol Ther, 34, 931, 10.1111/j.1365-2036.2011.04806.x · DOI
  22. Limketkai, 2016, Short bowel syndrome and intestinal failure in crohn's disease, Inflamm Bowel Dis, 22, 1209, 10.1097/MIB.0000000000000698 · DOI
  23. Crenn, 2004, Net digestive absorption and adaptive hyperphagia in adult short bowel patients, Gut, 53, 1279, 10.1136/gut.2003.030601 · DOI
  24. Cosnes, 1988, The overwhelmed intestine syndrome, Gastroenterol Clin Biol, 12, 339
  25. Pironi, 2008, Survival of patients identified as candidates for intestinal transplantation: a 3-year prospective follow-up, Gastroenterology, 135, 61, 10.1053/j.gastro.2008.03.043 · DOI
  26. Vargas, 1988, Chronic intestinal pseudo-obstruction syndrome in pediatrics. Results of a national survey by members of the North American Society of Pediatric Gastroenterology and Nutrition, J Pediatr Gastroenterol Nutr, 7, 323, 10.1097/00005176-198805000-00003 · DOI
  27. Jeppesen, 2014, Pharmacologic options for intestinal rehabilitation in patients with short bowel syndrome, JPEN J Parenter Enter Nutr, 38, 45S, 10.1177/0148607114526241 · DOI · Paper page

Cited by

Sorted by citations

Metadata

Authors
Joly, F., Baxter, J., Staun, M., Kelly, D. G., Hwa, Y. L., Corcos, O., De Francesco, A., Agostini, F., Klek, S., Santarpia, L., Contaldo, F., Jonker, C., Wanten, G., Chicharro, L., Burgos, R., Van Gossum, A., Cuerda, C., Virgili, N., & Pironi, L.
Affiliations
  • Hôpital Beaujon (FR)
  • National Health Service (GB)
  • Rigshospitalet (DK)
  • Mayo Clinic (US)
  • IRCCS Azienda Ospedliero-Universitaria di Bologna Policlinico di Sant'Orsola (IT)
  • University of Naples Federico II (IT)
  • Amsterdam UMC Location University of Amsterdam (NL)
  • Radboud University Medical Center (NL)
  • Vall d'Hebron Hospital Universitari (ES)
  • Hospital General Universitario Gregorio Marañón (ES)
  • Bellvitge University Hospital (ES)
Corresponding author
Joly, Francisca
ORCID
Venue
Clinical Nutrition
Publisher
Elsevier BV
Published
2018-08
Volume
37
Issue
4
Pages
1415-1422
ISSN
0261-5614 (ISSN-L)
DOI
10.1016/j.clnu.2017.06.016
OpenAlex
W2699131118
Cited by
98
References
0
Citations by year
2026: 15 · 2025: 7 · 2024: 9 · 2023: 14 · 2022: 6 · 2021: 10 · 2020: 18 · 2019: 10 · 2018: 8
FWCI
8.42
Type
journal article
Language
en
Open access
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Clinical Nutrition (publishedVersion)
  • PubMed (publishedVersion)
  • Discovery Research Portal (University of Dundee) (publishedVersion)
  • Radboud Repository (Radboud University) (submittedVersion)
  • Data Archiving and Networked Services (DANS) (submittedVersion)
  • Archivio istituzionale della ricerca (Alma Mater Studiorum Università di Bologna) (submittedVersion)
  • Dépôt institutionnel de l'Université libre de Bruxelles (Université Libre de Bruxelles) (submittedVersion)
  • Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
Topics
  • Health Sciences › Nursing › Nutrition and Dietetics › Clinical Nutrition and Gastroenterology
  • Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Central Venous Catheters and Hemodialysis
  • Health Sciences › Medicine › Nephrology › Dialysis and Renal Disease Management
Keywords
home parenteral nutrition, chronic intestinal failure, five-year survival, causes of death, weaning from parenteral nutrition, intestinal transplantation, Crohn's disease, fistula, mortality risk
MeSH terms
Adolescent, Adult, Aged, Chronic Disease, Female, Humans, Intestinal Diseases, Male, Middle Aged, Retrospective Studies, Parenteral Nutrition, Home, Young Adult

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review