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Physiology of Transition from Intrauterine to Extrauterine Life
Open accessAbstract
Summary The transition from a fetus to a newborn is the most complex adaptation that occurs in human experience. Lung adaptation requires the coordinated clearance of fetal lung fluid, surfactant secretion, and the onset of consistent breathing. With the removal of the low-pressure placenta, the cardiovascular response requires striking changes in blood flow, pressures and pulmonary vasodilation. The newborn must also quickly control its energy metabolism and thermoregulation. The primary mediators that both prepare the fetus for birth and support the multi-organ transition are cortisol and catecholamine. Abnormalities in adaptation are frequently found following preterm birth or delivery by cesarean section at term, and many of these infants will need delivery room resuscitation to assist in this transition.
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Cited by
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Forhead, A. J., & Fowden, A. L. (2014) · Journal of Endocrinology · doi:10.1530/joe-14-0025 · Cited by 423
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Ben-Ari, Y. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.08.001 · Cited by 305
Cerritelli, F., Frasch, M. G., Antonelli, M. C., Viglione, C., Vecchi, S., Chiera, M., & Manzotti, A. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.721605 · Cited by 108
Monitoring of the newborn dog and prediction of neonatal mortality
Mila, H., Grellet, A., Delebarre, M., Mariani, C., Feugier, A., & Chastant-Maillard, S. (2017) · Preventive Veterinary Medicine · doi:10.1016/j.prevetmed.2017.05.005 · Cited by 92
Chiesa, M., Guimond, D., Tyzio, R., Pons-Bennaceur, A., Lozovaya, N., Burnashev, N., Ferrari, D. C., & Ben-Ari, Y. (2019) · Cerebral Cortex · doi:10.1093/cercor/bhy112 · Cited by 30
Metadata
- Authors
- Hillman, N. H., Kallapur, S. G., & Jobe, A. H.
- Venue
- Clinics in Perinatology
- Publisher
- Elsevier BV
- Published
- 2012-12
- Volume
- 39
- Issue
- 4
- Pages
- 769-783
- ISSN
- 0095-5108 (ISSN-L)
- OpenAlex
- W1974218779
- Cited by
- 456
- References
- 0
- FWCI
- 7.11
- Type
- journal article
- Language
- en
- Open access
- green
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