Term or Preterm Cesarean Section Delivery Does Not Lead to Long-term Detrimental Consequences in Mice
Abstract
Epidemiological studies have provided contradictory data on the deleterious sequels of cesarean section (C-section) delivery and their links with developmental brain disorders such as Autism Spectrum Disorders. To gain better insight on these issues, we have now compared physiological, morphological, and behavioral parameters in vaginal, term, and preterm C-section delivered mice. We report that C-section delivery does not lead to long-term behavioral alterations though preterm C-section delivery modifies communicative behaviors in pups. Moreover, C-section delivery neither alters the gamma-aminobutyric acid (GABA) developmental excitatory to inhibitory shift nor the frequency or amplitude of glutamatergic and GABAergic postsynaptic currents in hippocampal pyramidal neurons. However, these neurons present an underdeveloped dendritic arbor at birth in pups born by C-section delivery, but this difference disappears 1 day later suggesting an accelerated growth after birth. Therefore, C-section delivery, with prematurity as an aggravating factor, induces transient developmental delays but neither impacts the GABA developmental sequence nor leads to long-term consequences in mice. The deleterious sequels of C-section delivery described in epidemiological studies might be due to a perinatal insult that could be aggravated by C-section delivery.
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Cites
Lagercrantz, H., & Slotkin, T. A. (1986) · Scientific American · doi:10.1038/scientificamerican0486-100 · Cited by 448 · see citing works
The GABA excitatory/inhibitory developmental sequence: A personal journey
Ben-Ari, Y. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.08.001 · Cited by 305 · see citing works
Self-citationA conserved switch in sensory processing prepares developing neocortex for vision
Colonnese, M. T., Kaminska, A., Minlebaev, M., Milh, M., Bloem, B., Lescure, S., Moriette, G., Chiron, C., Ben-Ari, Y., & Khazipov, R. (2010) · Neuron · doi:10.1016/j.neuron.2010.07.015 · Cited by 273 · see citing works
Self-citationPrenatal, perinatal, and neonatal factors associated with autism spectrum disorders
Bilder, D., Pinborough-Zimmerman, J., Miller, J., & McMahon, W. (2009) · Pediatrics · doi:10.1542/peds.2008-0927 · Cited by 222 · see citing works
Brander, G., Rydell, M., Kuja-Halkola, R., Fernández de la Cruz, L., Lichtenstein, P., Serlachius, E., Rück, C., Almqvist, C., D’Onofrio, B. M., Larsson, H., et al. (2016) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2016.2095 · Cited by 99 · see citing works
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Cryan, J. F., O'Riordan, K. J., Cowan, C. S. M., Sandhu, K. V., Bastiaanssen, T. F. S., Boehme, M., Codagnone, M. G., Cussotto, S., Fulling, C., Golubeva, A. V., et al. (2019) · Physiological Reviews · doi:10.1152/physrev.00018.2018 · Cited by 5,286 · see citing works
Enduring behavioral effects induced by birth by caesarean section in the mouse
Morais, L. H., Golubeva, A. V., Moloney, G. M., Moya-Pérez, A., Ventura-Silva, A. P., Arboleya, S., Bastiaanssen, T. F. S., O’Sullivan, O., Rea, K., Borre, Y., et al. (2020) · Current Biology · doi:10.1016/j.cub.2020.07.044 · Cited by 104 · see citing works
- Authors
- Chiesa, M., Guimond, D., Tyzio, R., Pons-Bennaceur, A., Lozovaya, N., Burnashev, N., Ferrari, D. C., & Ben-Ari, Y.
- Affiliations
- Inserm (FR)
- Neurochlore (France) (FR)
- Neurochlore, Fundamental Research Department, bâtiment Beret-Delaage, Parc scientifique et technologique de Luminy, 13288 Marseille cedex, France
- Corresponding author
- Ferrari, Diana C
- Venue
- Cerebral Cortex
- Publisher
- Oxford University Press (OUP)
- Published
- 2018-04-26
- Volume
- 29
- Issue
- 6
- Pages
- 2424-2436
- ISSN
- 1047-3211 (ISSN-L)
- 1460-2199
- OpenAlex
- W2946670627
- Cited by
- 30
- References
- 5
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 2 · 2023: 3 · 2022: 3 · 2021: 5 · 2020: 6 · 2019: 4 · 2018: 3
- FWCI
- 5.08
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cerebral Cortex (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Fondation Bettencourt Schueller (ANR-14-CE13-0021-01)
- A*MIDEX (A*M-AAP-TR-14-02-140522-13.02-BURNASHEV-HLS)
- Topics
- Health Sciences › Medicine › Obstetrics and Gynecology › Maternal and Perinatal Health Interventions
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Neonatal and fetal brain pathology
- Life Sciences › Neuroscience › Developmental Neuroscience › Anesthesia and Neurotoxicity Research
- Keywords
- cesarean section, preterm birth, term birth, autism spectrum disorder, perinatal brain development, excitation-inhibition balance, hippocampal pyramidal neurons, postsynaptic currents, dendritic arbor development, mouse model
- MeSH terms
- Animals, Behavior, Animal, Cesarean Section, Developmental Disabilities, Female, Male, Pregnancy, Pyramidal Cells, Premature Birth, Mice, CA3 Region, Hippocampal
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