Key Inflammatory Biomarkers in Perinatal Asphyxia
Abstract
This article summarizes the current evidence regarding inflammatory biomarkers (placental and postnatal) and provides a comprehensive understanding of their roles: (1) diagnostic accuracy to predict the severity of hypoxic-ischemia encephalopathy (HIE), (2) value in assessing treatment responses, and (3) prediction of both short- and long-term neurodevelopmental outcomes. In the early critical stages of perinatal asphyxia, inflammatory biomarkers may guide clinical decision-making. Additional research is required to increase our understanding of the optimal utility of biomarkers to predict the severity, evolution, and developmental outcomes after exposure to HIE.
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A single biomarker is unlikely to reliably predict long-term outcomes.
“While a single biomarker is unlikely to reliably predict long-term outcomes (17)”
From Association of the neonatal sequential organ failure assessment score with neurological outcomes in infants diagnosed with hypoxic-ischemic encephalopathy (2026) · cites this paper as [17]
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- Authors
- Bitar, L., Stonestreet, B. S., & Chalak, L. F.
- Affiliations
- The University of Texas Southwestern Medical Center (US)
- Brown University (US)
- Corresponding author
- Chalak, Lina F.
- Venue
- Clinics in Perinatology
- Publisher
- Elsevier BV
- Published
- 2024-09
- Volume
- 51
- Issue
- 3
- Pages
- 617-628
- ISSN
- 0095-5108 (ISSN-L)
- OpenAlex
- W4398223749
- Semantic Scholar
- 1f68d290b8dddacc8c765b96517a67ce7829b6b6
- Cited by
- 7
- References
- 70
- Citations by year
- 2026: 3 · 2025: 4
- FWCI
- 0.82
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Clinics in Perinatology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Neonatal and fetal brain pathology
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Infant Development and Preterm Care
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Neonatal and Maternal Infections
- Keywords
- perinatal asphyxia, inflammatory markers, hypoxic-ischemic encephalopathy, placental biomarkers, neurodevelopmental outcome prediction, treatment response assessment, diagnostic accuracy, neonatal brain injury
- MeSH terms
- Asphyxia Neonatorum, Female, Humans, Infant, Newborn, Inflammation, Placenta, Pregnancy, Biomarkers, Hypoxia-Ischemia, Brain
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