Cited by 7Neonatal and fetal brain pathologyInfant Development and Preterm CareNeonatal and Maternal Infections

Key Inflammatory Biomarkers in Perinatal Asphyxia

Bitar, Lynn, Stonestreet, Barbara S., Chalak, Lina F.·2024·Clinics in Perinatology

Abstract

This article summarizes the current evidence regarding inflammatory biomarkers (placental and postnatal) and provides a comprehensive understanding of their roles: (1) diagnostic accuracy to predict the severity of hypoxic-ischemia encephalopathy (HIE), (2) value in assessing treatment responses, and (3) prediction of both short- and long-term neurodevelopmental outcomes. In the early critical stages of perinatal asphyxia, inflammatory biomarkers may guide clinical decision-making. Additional research is required to increase our understanding of the optimal utility of biomarkers to predict the severity, evolution, and developmental outcomes after exposure to HIE.

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Crossref · 10.1016/j.clp.2024.04.004

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Authors
Bitar, L., Stonestreet, B. S., & Chalak, L. F.
Affiliations
  • The University of Texas Southwestern Medical Center (US)
  • Brown University (US)
Corresponding author
Chalak, Lina F.
Venue
Clinics in Perinatology
Publisher
Elsevier BV
Published
2024-09
Volume
51
Issue
3
Pages
617-628
ISSN
0095-5108 (ISSN-L)
OpenAlex
W4398223749
Cited by
7
References
70
Citations by year
2026: 3 · 2025: 4
FWCI
0.82
Type
journal article
Language
en
Open access
closed
Locations
  • Clinics in Perinatology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Neonatal and fetal brain pathology
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Infant Development and Preterm Care
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Neonatal and Maternal Infections
Keywords
perinatal asphyxia, inflammatory markers, hypoxic-ischemic encephalopathy, placental biomarkers, neurodevelopmental outcome prediction, treatment response assessment, diagnostic accuracy, neonatal brain injury
MeSH terms
Asphyxia Neonatorum, Female, Humans, Infant, Newborn, Inflammation, Placenta, Pregnancy, Biomarkers, Hypoxia-Ischemia, Brain

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