The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Transporters and drug therapy: Implications for drug disposition and disease
Abstract
The efficacy of drug therapy results from the complex interplay of multiple processes that govern drug disposition and response. Most studies to date have focused on the contribution of drug-metabolizing enzymes to the drug disposition process. However, over the past decade, it has become increasingly apparent that carrier-mediated processes, or transporters, also play critical roles in the overall disposition of numerous drugs in clinical use. In addition to their roles in xenobiotic transport, drug transporters often mediate important physiologic functions via transport of endogenous substrates such as amino acids, bile acids, and hormones that are critical for maintenance of normal homeostasis. In this review we focus on the emerging field of transporter proteins in relation to the drug disposition process, with particular emphasis on clinical implications of transporters to drug-drug interactions and subsequent development of adverse effects, interindividual variability in drug response, and human disease.
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Cites
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Eloranta, J. J., & Kullak-Ublick, G. A. (2005) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2004.09.019 · Cited by 260
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Chalasani, N., & Björnsson, E. (2010) · Gastroenterology · doi:10.1053/j.gastro.2010.04.001 · Cited by 347
Predicting Clearance Mechanism in Drug Discovery: Extended Clearance Classification System (ECCS)
Varma, M. V., Steyn, S. J., Allerton, C., & El-Kattan, A. F. (2015) · Pharmaceutical Research · doi:10.1007/s11095-015-1749-4 · Cited by 334
PBPK modelling of inter-individual variability in the pharmacokinetics of environmental chemicals
Bois, F. Y., Jamei, M., & Clewell, H. J. (2010) · Toxicology · doi:10.1016/j.tox.2010.06.007 · Cited by 194
Huang, Q., & Riviere, J. E. (2014) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1517/17425255.2014.934671 · Cited by 149
Sundaram, V., & Björnsson, E. S. (2017) · Hepatology Communications · doi:10.1002/hep4.1088 · Cited by 138
Impact of genetic variation in OATP transporters to drug disposition and response
Gong, I. Y., & Kim, R. B. (2013) · Drug Metabolism and Pharmacokinetics · doi:10.2133/dmpk.dmpk-12-rv-099 · Cited by 137
Self-citationCiprofloxacin and Rifampin have opposite effects on levothyroxine absorption
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Metadata
- Authors
- HO, R., & KIM, R.
- Venue
- Clinical Pharmacology & Therapeutics
- Publisher
- Wiley
- Published
- 2005-09
- Volume
- 78
- Issue
- 3
- Pages
- 260-277
- ISSN
- 0009-9236 (ISSN-L)
- OpenAlex
- W1992237854
- Cited by
- 502
- References
- 5
- FWCI
- 15.97
- Type
- journal article
- Language
- en
- Open access
- closed
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