The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Environmental and genetic factors associated with morphine response in the postoperative period
Open accessAbstract
OBJECTIVE: The aim of this study was to investigate the respective influence of genetic and nongenetic factors on morphine dose requirements and adverse effects after colorectal surgery. METHODS: Seventy-four patients who planned to undergo colorectal surgery were included in this pilot study. The cumulative 24-hour postoperative dose of morphine and postoperative nausea or vomiting requiring the antiemetic ondansetron were the 2 clinical end points. The association of patient characteristics, A118G mu-opioid receptor (OPRM1) single-nucleotide polymorphism (SNP); T802C uridine diphosphate-glucuronosyltransferase 2B7 (UGT2B7) SNP; and 2 adenosine triphosphate-binding cassette, subfamily B, member 1 (ABCB1) (multidrug resistance 1 [MDR1]) exonic SNPs (G2677T/A and C3435T) with study end points was investigated. RESULTS: Age, creatinine clearance, and the regular use of psychotropic agents were found to be significantly associated with postoperative morphine dose requirements by univariate analysis. Multivariate analysis identified that age (P = .01) and the use of psychotropic agents before surgery (P = .03) were positively associated with a higher rate of morphine consumption. A higher weight (P = .05) and the ABCB1 homozygous GG-CC diplotype (P = .03) were significantly associated with fewer morphine side effects by univariate analysis. The homozygous ABCB1 diplotype (GG-CC) conferred an odds ratio of 0.12 (95% confidence interval, 0.01-0.98) with regard to the use of ondansetron for postoperative nausea or vomiting. Multivariate analysis identified that the ABCB1 GG-CC diplotype was the only borderline-significant (P = .07) predictive factor of morphine side effects. CONCLUSION: Age and prior use of psychotropic agents are associated with postoperative morphine dose requirements. Whether ABCB1 polymorphisms might predict morphine side effects remains to be determined.
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Nilsson, U., Unosson, M., & Rawal, N. (2005) · European Journal of Anaesthesiology · doi:10.1017/s0265021505000189 · Cited by 209
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Ip, H. Y. V., Abrishami, A., Peng, P. W. H., Wong, J., & Chung, F. (2009) · Anesthesiology · doi:10.1097/aln.0b013e3181aae87a · Cited by 1,055
The neural bases of social pain: Evidence for shared representations with physical pain
Eisenberger, N. I. (2012) · Psychosomatic Medicine · doi:10.1097/psy.0b013e3182464dd1 · Cited by 492
Sia, A. T., Lim, Y., Lim, E. C. P., Goh, R. W. C., Law, H. Y., Landau, R., Teo, Y.-Y., & Tan, E. C. (2008) · Anesthesiology · doi:10.1097/aln.0b013e318182af21 · Cited by 297
Pathophysiological and neurochemical mechanisms of postoperative nausea and vomiting
Horn, C. C., Wallisch, W. J., Homanics, G. E., & Williams, J. P. (2014) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2013.10.037 · Cited by 288
Way, B. M., Taylor, S. E., & Eisenberger, N. I. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0812612106 · Cited by 264
Metadata
- Authors
- COULBAULT, L., BEAUSSIER, M., VERSTUYFT, C., WEICKMANS, H., DUBERT, L., TREGOUET, D., DESCOT, C., PARC, Y., LIENHART, A., & JAILLON, P.
- Venue
- Clinical Pharmacology & Therapeutics
- Publisher
- Wiley
- Published
- 2006-04
- Volume
- 79
- Issue
- 4
- Pages
- 316-324
- ISSN
- 0009-9236 (ISSN-L)
- OpenAlex
- W2006582768
- Cited by
- 248
- References
- 1
- FWCI
- 13.15
- Type
- journal article
- Language
- en
- Open access
- bronze
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- COULBAULT, L., BEAUSSIER, M., VERSTUYFT, C., WEICKMANS, H., DUBERT, L., TREGOUET, D., DESCOT, C., PARC, Y., LIENHART, A., & JAILLON, P. (2006). Environmental and genetic factors associated with morphine response in the postoperative period. Clinical Pharmacology & Therapeutics. https://doi.org/10.1016/j.clpt.2006.01.007
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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