The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
A118G Single Nucleotide Polymorphism of Human μ-Opioid Receptor Gene Influences Pain Perception and Patient-controlled Intravenous Morphine Consumption after Intrathecal Morphine for Postcesarean Analgesia
Open accessAbstract
Background: Previous studies have shown that genetic variability at position 118 of the human mu-opioid receptor gene altered patients' response to intravenous morphine. The purpose of this study was to investigate whether this polymorphism contributes to the variability in response to morphine for postcesarean analgesia. Methods: After investigators obtained informed consent, 588 healthy women received 0.1 mg intrathecal morphine for postcesarean analgesia. Their blood samples were genotyped for the A118G polymorphism-A118 homozygous (AA), heterozygous (AG), or homozygous for the G allele (GG). Pain scores, the severity of nausea and vomiting, the incidence of pruritus, and the total self-administered intravenous morphine were recorded for the first 24 postoperative hours. Results: Two hundred seventy women (46%) were AA, 234 (40%) were AG, and 82 (14%) were GG. The 24-h self-administered intravenous morphine consumption was lowest in the AA group (P = 0.001; mean, 5.9; 95% confidence interval, 5.1-6.8) versus the AG (8.0; 6.9-9.1) and GG groups (9.4; 7.3-11.5). Pain scores were lowest in the AA group and highest in the GG group, with a statistically significant difference detected between AA, AG, and GG (P = 0.049). Total morphine consumption was also influenced by patients' age and paying status. AA group was associated with the highest incidence of nausea (26 of 272 [9.6%]; P = 0.02) versus the other two groups (13 of 234 [5.6%] and 1 of 82 [1.2%] for AG and GG, respectively). Conclusion: Genetic variation at position 118 of the mu-opioid receptor is associated with interindividual differences in pain scores, self-administered intravenous morphine, and the incidence of nausea postoperatively.
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Pathophysiological and neurochemical mechanisms of postoperative nausea and vomiting
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Metadata
- Authors
- Sia, A. T., Lim, Y., Lim, E. C. P., Goh, R. W. C., Law, H. Y., Landau, R., Teo, Y.-Y., & Tan, E. C.
- Venue
- Anesthesiology
- Published
- 2008-09-01
- Volume
- 109
- Issue
- 3
- Pages
- 520-526
- ISSN
- 0003-3022 (ISSN-L)
- OpenAlex
- W1974645621
- Cited by
- 297
- References
- 16
- FWCI
- 22.32
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: A118G Single Nucleotide Polymorphism of Human μ-Opioid Receptor Gene Influences Pain Perception and Patient-controlled Intravenous Morphine Consumption after Intrathecal Morphine for Postcesarean Analgesia. https://app.cochat.ai/papers/10.1097/aln.0b013e318182af21
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- Sia, A. T., Lim, Y., Lim, E. C. P., Goh, R. W. C., Law, H. Y., Landau, R., Teo, Y.-Y., & Tan, E. C. (2008). A118G Single Nucleotide Polymorphism of Human μ-Opioid Receptor Gene Influences Pain Perception and Patient-controlled Intravenous Morphine Consumption after Intrathecal Morphine for Postcesarean Analgesia. Anesthesiology. https://doi.org/10.1097/aln.0b013e318182af21
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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