More than satiety: central serotonin signaling and glucose homeostasis.
Open accessAbstract
Serotonergic agents have been used in the past for reduction of appetite and body weight. As reported by Zhou et al. (2007) in this issue of Cell Metabolism, they also have unexpected effects on peripheral glucose homeostasis independent of food intake and body weight.
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Leptin signaling has important modulatory effects on dopaminergic neurons that are part of reward pathways that provide input to the nucleus accumbens.
“It has recently become clear, however, that leptin signaling has important modulatory effects on dopaminergic neurons that are part of reward pathways that provide input to the nucleus accumbens (50,51).”
From Leptin at 14 y of age: an ongoing story (2009) · cites this paper as [50]
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Leptin at 14 y of age: an ongoing story
Friedman, J. M. (2009) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.2008.26788b · Cited by 272 · see citing works
The diverse metabolic roles of peripheral serotonin
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Mitochondrial fatty acid oxidation in obesity
Serra, D., Mera, P., Malandrino, M. I., Mir, J. F., & Herrero, L. (2013) · Antioxidants & Redox Signaling · doi:10.1089/ars.2012.4875 · Cited by 246 · see citing works
Antipsychotics and glucose metabolism: how brain and body collide
Kowalchuk, C., Castellani, L. N., Chintoh, A., Remington, G., Giacca, A., & Hahn, M. K. (2019) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00164.2018 · Cited by 85 · see citing works
- Authors
- Pissios, P., & Maratos-Flier, E.
- Affiliations
- Beth Israel Deaconess Medical Center (US)
- Venue
- Cell Metabolism
- Publisher
- Elsevier BV
- Published
- 2007-11
- Volume
- 6
- Issue
- 5
- Pages
- 345-347
- ISSN
- 1550-4131 (ISSN-L)
- PMC
- PMC3619724
- OpenAlex
- W2061155921
- Cited by
- 20
- References
- 11
- Citations by year
- 2021: 3 · 2019: 2 · 2018: 1 · 2017: 2 · 2015: 2 · 2014: 1 · 2013: 3 · 2012: 1
- FWCI
- 0.27
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (5r01dk069983-05)
- National Institute on Drug Abuse (R01DA056113)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK056113, P01DK056116, R01-DK-069983)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Keywords
- serotonin, glucose homeostasis, appetite, body weight, peripheral glucose metabolism, satiety
- MeSH terms
- Animals, Glucose, Homeostasis, Models, Biological, Signal Transduction, Serotonin Receptor Agonists, Mice, Serotonin 5-HT2 Receptor Agonists
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