The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
Reduced Apoptosis and Plaque Necrosis in Advanced Atherosclerotic Lesions of Apoe−/− and Ldlr−/− Mice Lacking CHOP
Open accessAbstract
SUMMARY Endoplasmic reticulum (ER) stress is a hallmark of advanced atherosclerosis, but its causative role in plaque progression is unknown. In-vitro studies have implicated the ER stress effector CHOP in macrophage apoptosis, a process involved in plaque necrosis in advanced atheromata. To test the effect of CHOP deficiency in vivo, aortic root lesions of fat-fed Chop+/+;Apoe−/− and Chop−/−;Apoe−/− mice were analyzed for size and morphology. Despite similar plasma lipoproteins, lesion area was 35% smaller in Chop−/−;Apoe−/− mice. Most importantly, plaque necrosis was reduced by ~50% and lesional apoptosis by 35% in the CHOP-deficient mice. Similar results were found in fat-fed Chop−/−;Ldlr−/− vs. Chop+/+;Ldlr−/− mice. Thus, CHOP promotes plaque growth, apoptosis, and plaque necrosis in fat-fed Apoe−/− and Ldlr−/− mice. These data provide direct evidence for a causal link between the ER stress effector CHOP and plaque necrosis and suggest that interventions weakening this arm of the UPR may lessen plaque progression.
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Self-citationIRE1 Signaling Affects Cell Fate During the Unfolded Protein Response
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Self-citationTranslational control in the endoplasmic reticulum stress response
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Self-citationPhagocytosis of apoptotic cells by macrophages is impaired in atherosclerosis
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Cited by
Macrophages in the Pathogenesis of Atherosclerosis
Moore, K. J., & Tabas, I. (2011) · Cell · doi:10.1016/j.cell.2011.04.005 · Cited by 2,669
Self-citationAtherosclerosis: current pathogenesis and therapeutic options
Weber, C., & Noels, H. (2011) · Nature Medicine · doi:10.1038/nm.2538 · Cited by 2,203
Reactive Oxygen Species in Metabolic and Inflammatory Signaling
Forrester, S. J., Kikuchi, D. S., Hernandes, M. S., Xu, Q., & Griendling, K. K. (2018) · Circulation Research · doi:10.1161/circresaha.117.311401 · Cited by 2,081
ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death
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Macrophage Phenotype and Function in Different Stages of Atherosclerosis
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Metadata
- Authors
- Thorp, E., Li, G., Seimon, T. A., Kuriakose, G., Ron, D., & Tabas, I.
- Venue
- Cell Metabolism
- Publisher
- Elsevier BV
- Published
- 2009-05
- Volume
- 9
- Issue
- 5
- Pages
- 474-481
- ISSN
- 1550-4131 (ISSN-L)
- OpenAlex
- W2027966439
- Cited by
- 340
- References
- 34
- FWCI
- 10.31
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Thorp, E., Li, G., Seimon, T. A., Kuriakose, G., Ron, D., & Tabas, I. (2009). Reduced Apoptosis and Plaque Necrosis in Advanced Atherosclerotic Lesions of Apoe−/− and Ldlr−/− Mice Lacking CHOP. Cell Metabolism. https://doi.org/10.1016/j.cmet.2009.03.003
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